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Biomedical subjects

Mathias Stecker

Publications and source records attributed to Mathias Stecker.

2 recordsLinked to original sources

The effect of large single radiation doses on cochlear implant function: implications for radiosurgery.

The purpose of this study was to investigate the effect of large single doses of radiation on the function of a cochlear implant. A cochlear implant (Nucleus 24 k, Cochlear Ltd., Sydney, Australia) was implanted into a cadaver head and tested for functional changes following irradiation. Within 2 h, the device was given single fractions of 16.3 Gy, 6.2 Gy and 20 Gy with 6 MV photons. The size of the fractions was derived from maximum doses registered in linear accelerator-based radiosurgery of more than 300 patients treated for benign or malignant tumors at the Department of Radiation Therapy of the University Hospital of Freiburg. After each treatment an integrity test was performed testing the impedance and current output of the CI system. The total dose of 42.5 Gy caused no changes with regard to the tested parameters. The risk of implant failure seems to be low for Nucleus 24 k cochlear implants exposed to large single doses of radiation as used in radiosurgery.

Cadaver↗

Threshold, comfortable level and impedance changes as a function of electrode-modiolar distance.

OBJECTIVE: The study investigated the hypothesis that threshold and comfortable levels recorded from cochlear implant patients would reduce, and dynamic range increase, as distance of the electrode from the modiolar wall (radial distance) decreases. Two groups of cochlear implant patients participated; one group using the Nucleus' 24 Contour electrode array, and one group using the Nucleus standard straight (banded) array. The Nucleus 24 Contour array has been shown in temporal bone studies to lie closer to the modiolus than the banded array. The relationship of electrode impedance and radial distance is also investigated. DESIGN: The study, conducted at three centers, evaluated 21 patients using the Contour array, and 36 patients using the banded array. For each patient, threshold, comfortable levels and dynamic range were measured at four time points. Common ground electrode impedance was recorded clinically from each patient, at time intervals up to 12 wk. An estimate of the radial distance of the electrode from the modiolus was made by analysis of Cochlear view x-rays. RESULTS: Threshold and comfortable levels were significantly lower for the Nucleus 24 Contour array than for the banded array. However, dynamic range measurements did not show the predicted increase. In a majority of subjects, a significant correlation was found between the estimated radial distance of the electrode from the modiolus and the measured threshold and comfortable levels. This trend was not observed for dynamic range. The analysis indicates that other factors than radial distance are involved in the resultant psychophysical levels. Clinical impedance measures (common ground) were found to be significantly higher for the Contour array. However, the electrodes on the Contour array are half-rings, which are approximately only half the geometric size of the full rings as electrodes of the standard array. When the geometric electrode area in the two array designs are normalized, the trends in the electrode impedance behavior are similar. CONCLUSIONS: The results support the hypothesis that the relationship between the radial distance of the electrode and the psychophysical measures are influenced by patterns of fibrous tissue growth and individual patient differences, such as etiology and neural survival. Impedance measures for the Nucleus 24 Contour electrode array were higher than the banded electrode array, but this is primarily due to the reduction in electrode surface area. The different outcomes in impedance over time suggest differences in the relative contributions of the components of impedance with the two arrays.

Acoustic Impedance Tests↗