Biomedical subjects

Matjaz Perc

Publications and source records attributed to Matjaz Perc.

8 recordsLinked to original sources

PubMed2006

Minimal model for spatial coherence resonance.

We show that a planar medium, locally modeled by a simple one-dimensional excitable system with a piece-wise linear potential, can serve as a minimal model for spatial coherence resonance. Via an analytical treatment of the spatially extended system, we derive the dependence of the resonant wave number on several crucial system parameters, ranging from the diffusion coefficient to the local excursion time of constitutive excitable units. Thus, we provide vital insights into mechanisms that enable the emergence of exclusively noise-induced spatial periodicity in excitable media.

Journal Article↗

PubMed2005

A minimal model for decoding of time-limited Ca2+ oscillations.

Calcium oscillations regulate several cellular processes by activating particular proteins. Most theoretical studies focused on the idealized situation of infinitely long oscillations. Here we analyze information transfer by time-limited calcium spike trains. We show that proteins can be selectively activated in a resonance-like manner by time-limited spike trains of different frequencies, while infinitely long oscillations do not show this resonance phenomenon. We found that proteins are activated more specifically by shorter oscillatory signals with narrower spikes.

Biological Clocks↗

PubMed2005

Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations.

We show by mathematical modelling that a two-level protein cascade can act as a band-pass filter for time-limited oscillations. The band-pass filters are then combined into a network of three-level signalling cascades that by filtering the frequency of time-limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations.

Calcium Signaling↗

PubMed2005

Spatial coherence resonance in excitable media.

We study the phenomenon of spatial coherence resonance in a two-dimensional model of excitable media with FitzHugh-Nagumo local dynamics. In particular, we show that there exists an optimal level of additive noise for which an inherent spatial scale of the excitable media is best pronounced. We argue that the observed phenomenon occurs due to the existence of a noise robust excursion time that is characteristic for the local dynamics whereby the diffusion constant, representing the rate of diffusive spread, determines the actual resonant spatial frequency. Additionally, biological implications of presented results in the field of neuroscience are outlined.

Journal Article↗

PubMed2005

Amplification of information transfer in excitable systems that reside in a steady state near a bifurcation point to complex oscillatory behavior.

We study the amplification of information transfer in excitable systems. We show that excitable systems residing in a steady state near a bifurcation point to complex oscillatory behavior incorporate several frequencies that can be exploited for a resonant amplification of information transfer. In particular, for excitable neurons that reside in a steady state near a bifurcation point to elliptic bursting oscillations, we show that in addition to the resonant frequency of damped oscillations around the stable focus, another frequency exists that resonantly enhances large amplitude bursts and thus amplifies the information transfer in the system. This additional frequency cannot be found by the local stability analysis and has never been used for amplifying the information transfer in a system. The results obtained for elliptic bursting oscillations can be generalized also to other complex oscillators, such as parabolic or square-wave bursters. Additionally, the biological importance of presented results in the field of neuroscience is outlined.

Adaptation, Physiological↗

PubMed2004

Detecting and controlling unstable periodic orbits that are not part of a chaotic attractor.

A method for controlling unstable periodic orbits (UPOs) that have not been controllable before is presented. The method is based on detecting UPOs that are situated outside the skeleton of a chaotic attractor. The main idea is to exploit flexible parts of the attractor, which under weak external perturbations allow variable excursions of the trajectory away from its originally determined path. After the perturbation, the trajectory of the autonomous system seeks its path back to the chaotic attractor and reveals additional UPOs that are otherwise not used by the system. It is shown that these UPOs can be controlled as easily as the UPOs that form the basic chaotic attractor. The effectiveness of the proposed method is demonstrated on two different chaotic systems with very distinct response abilities to external perturbations. Additionally, some applications of the method in the fields of laser technology, information encoding, and biomedical engineering are discussed.

Journal Article↗

PubMed2004

Local dissipation and coupling properties of cellular oscillators: a case study on calcium oscillations.

Synchronised signal transduction between cells is crucial, since it assures fast and immutable information processing, which is vital for flawless functioning of living organisms. The question arises how to recognise the ability of a cell to be easily coupled with other cells. In the present paper, we investigate the system properties that determine best coupling abilities and assure the most efficient signal transduction between cells. A case study is done for intercellular calcium oscillations. For a particular diffusion-like coupled system of cellular oscillators, we determined the minimal gap-junctional permeability that is necessary for synchronisation of initially asynchronous oscillators. Our results show that dissipation is a crucial system property that determines the coupling ability of cellular oscillators. We found that low dissipation assures synchronisation of coupled cells already at very low gap-junctional permeability, whereas highly dissipative oscillators require much higher gap-junctional permeability in order to synchronise. The results are discussed in the sense of their biological importance for systems where the synchronous responses of cells were recognised to be indispensable for appropriate physiological functioning of the tissue.

Animals↗

PubMed2003

Sensitivity and flexibility of regular and chaotic calcium oscillations.

Sensitivity and flexibility are important properties of biological systems. These properties are here investigated for intracellular calcium oscillations. For a particular model, we comparatively investigate sensitivity and flexibility of regular and chaotic Ca(2+) oscillations. For this model, we obtain two main results. First, sensitivity of the model system to parameter shifting does not depend on the complexity of Ca(2+) oscillations. We observe, however, that both regular and chaotic Ca(2+) oscillations are highly sensitive in regions close to bifurcation points. Second, also flexibility of Ca(2+) oscillations does not significantly depend on the type of Ca(2+) oscillations. Our results show that regular as well as chaotic Ca(2+) oscillations in the studied model are highly flexible in regimes with weak dissipation. Both results are discussed in the sense of possible biological importance.

Calcium↗