Biomedical subjects

Maurits W van der Molen

Publications and source records attributed to Maurits W van der Molen.

At least 19 recordsLinked to original sources

PubMed2006

Developmental changes in oculomotor control and working-memory efficiency.

In the present study, we examined the developmental changes in the efficiency of saccadic inhibitory control. More specifically, the contribution of age-related changes in working-memory engagement was investigated. We manipulated the efficiency of inhibitory oculomotor control in antisaccade tasks by using fixation-offset conditions, which are supposed to affect inhibitory demands, and by adding increasing working-memory loads to the antisaccade task. In general, in comparison to antisaccade performance of adults, the antisaccade performance of 8-year-old and 12-year-old children was characterized by an increase in direction errors, and/or longer saccadic onset latencies on correct antisaccades. However, this pattern was not altered by the fixation-offset manipulations. In contrast, increased working-memory demands deteriorated 8-year-olds' antisaccade performance unequally as compared to older children and young adults. These findings suggest that - at least in young children - the available functional working-memory capacity is engaged in oculomotor inhibition.

Adolescent↗

PubMed2006

Age-related change in executive function: developmental trends and a latent variable analysis.

This study examined the developmental trajectories of three frequently postulated executive function (EF) components, Working Memory, Shifting, and Inhibition of responses, and their relation to performance on standard, but complex, neuropsychological EF tasks, the Wisconsin Card Sorting Task (WCST), and the Tower of London (ToL). Participants in four age groups (7-, 11-, 15-, and 21-year olds) carried out nine basic experimental tasks (three tasks for each EF), the WCST, and the ToL. Analyses were done in two steps: (1) analyses of (co)variance to examine developmental trends in individual EF tasks while correcting for basic processing speed, (2) confirmatory factor analysis to extract latent variables from the nine basic EF tasks, and to explain variance in the performance on WCST and ToL, using these latent variables. Analyses of (co)variance revealed a continuation of EF development into adolescence. Confirmatory factor analysis yielded two common factors: Working Memory and Shifting. However, the variables assumed to tap Inhibition proved unrelated. At a latent level, again correcting for basic processing speed, the development of Shifting was seen to continue into adolescence, while Working Memory continued to develop into young-adulthood. Regression analyses revealed that Working Memory contributed most strongly to WCST performance in all age groups. These results suggest that EF component processes develop at different rates, and that it is important to recognize both the unity and diversity of EF component processes in studying the development of EF.

Adolescent↗

PubMed2006

Switching between tasks and responses: a developmental study.

Task switching requires the ability to flexibly switch between task rules and responses, and is sensitive to developmental change. We tested the hypothesis that developmental changes in task switch performance are associated with changes in the facilitating or interfering effect of the previously retrieved stimulus-response (S-R) association. Three age groups (7-8-year-olds, 10-12-year-olds and 20-25-year-olds) performed a two-choice reaction time (RT) task in which spatially compatible or incompatible responses were required. The RT costs associated with switching between tasks were larger when responses were repeated than when responses were alternated. Younger children showed a greater cost than adults when switching between tasks but repeating responses. This age difference decreased when the interval between the previous response and the upcoming stimulus increased. Switch costs were larger when switching to the compatible task than to the incompatible task, but this effect did not differ between age groups. These findings suggest that young children build up stronger transient associations between task sets and response sets, which interfere with their ability to switch to currently intended actions. A similar pattern has previously been observed for older adults (Mayr, 2001), suggesting a common contributor to task switching deficits across the life span.

Adult↗

PubMed2006

Stimulation of the subthalamic region facilitates the selection and inhibition of motor responses in Parkinson's disease.

The aim of the present study was to specify the involvement of the basal ganglia in motor response selection and response inhibition. Two samples were studied. The first sample consisted of patients diagnosed with Parkinson's disease (PD) who received deep-brain stimulation (DBS) of the subthalamic nucleus (STN). The second sample consisted of patients who received DBS for the treatment of PD or essential tremor (ET) in the ventral intermediate nucleus of the thalamus (Vim). Stop-signal task and go/no-go task performances were studied in both groups. Both groups performed these tasks with (on stimulation) and without (off stimulation) DBS to address the question of whether stimulation is effective in improving choice reaction time (RT) and stop-signal RT. The results show that DBS of the STN was associated with significantly enhanced inhibitory control, as indicated by shorter stop-signal RTs. An additional finding is that DBS of the STN led to significantly shorter choice RT. The effects of DBS on responding and response inhibition were functionally independent. Although DBS of the Vim did not systematically affect task performance in patients with ET, a subgroup of Vim-stimulated PD patients showed enhanced stop-signal RTs in on stimulation versus off stimulation. This result suggests that the change in performance to stop signals may not be directly related to STN function, but rather results from a change in PD function due to DBS in general. The findings are discussed in terms of current functional and neurobiological models that relate basal ganglia function to the selection and inhibition of motor responses.

Adult↗

PubMed2005

Cardiac concomitants of performance monitoring: context dependence and individual differences.

Feedback processing is an important aspect of cognitive control and decision-making. Several studies have shown that heart rate slows following feedback that indicates incorrect performance or loss of money. The current study was the first to investigate (1) whether this slowing reflects an evaluation of the valence of the outcome or a system that indicates that the feedback contains informative value, (2) whether the slowing is determined by the value of the outcome relative to the range of possible outcomes, and (3) whether highly anxious individuals have a hypersensitive feedback monitoring system. The results showed that heart rate only slows when the feedback is performance based. The information provided by negative feedback is processed in a context-sensitive manner, suggesting that heart rate slowing following feedback reflects a signal associated with informative value for subsequent performance adjustment. Highly anxious individuals showed larger heart rate slowing in response to feedback indicating high stakes, but they failed to respond to feedback in a context-sensitive manner. These results were interpreted to suggest that anxious individuals are generally more sensitive to performance outcomes. Heart rate changes following informative feedback proved to be a sensitive index of component processes associated with performance monitoring.

Adolescent↗

PubMed2005

Preparation for speeded action as a psychophysiological concept.

Mental preparation aids performance and induces multiple physiological changes that should inform concepts of preparation. To date, however, these changes have been interpreted as being due to a global preparatory process (e.g., attention or alertness). The authors review psychophysiological and performance investigations of preparation. Concepts of the central regulation of action offer an integrative framework for understanding the psychophysiology of preparation. If people process multiple streams of information concurrently, then preparatory processing requires a form of supervisory attention- central regulation to maintain unity of action. This concept is consistent with existing psychophysiological results and links them to current views of information processing. Conversely, psychophysiological measures may provide indices to test concepts within theories of the central regulation of action.

Arousal↗

PubMed2005

Characterization of children's decision making: sensitivity to punishment frequency, not task complexity.

On a gambling task that models real-life decision making, children between ages 7 and 12 perform like patients with bilateral lesions of the ventromedial prefrontal cortex (VMPFC), opting for choices that yield high immediate gains in spite of higher future losses (Crone & Van der Molen, 2004). The current study set out to characterize developmental changes in decision making by varying task complexity and punishment frequency. Three age groups (7-9 years, 10-12 years, 13-15 years) performed two versions of a computerized variant of the original Iowa gambling task. Task complexity was manipulated by varying the number of choices participants could make. Punishment frequency was manipulated by varying the frequency of delayed punishment. Results showed a developmental increase in the sensitivity to future consequences, which was present only when the punishment was presented infrequently. These results could not be explained by differential sensitivity to task complexity, hypersensitivity to reward, or failure to switch response set after receiving punishment. There was a general pattern of boys outperforming girls by making more advantageous choices over the course of the task. In conclusion, 7-12-year-old children--like VMPFC patients--appear myopic about the future except when the potential for future punishment is high.

Adolescent↗

PubMed2004

Sequential effects on speeded information processing: a developmental study.

Two experiments were performed to assess age-related changes in sequential effects on choice reaction time (RT). Sequential effects portray the influence of previous trials on the RT to the current stimulus. In Experiment 1, three age groups (7-9, 10-12, and 18-25 years) performed a spatially compatible choice task, with response-to-stimulus intervals (RSIs) of 50 and 500 ms varied between trial blocks. In Experiment 2, three age groups (7-9, 15-16, and 18-25 years) performed the task with spatial stimulus-response (S-R) mappings (compatible versus incompatible) varied between participants. For adults, the experiments yielded a pattern of sequential effects suggestive of "automatic facilitation" (i.e., a first-order repetition effect and a higher order benefit-only pattern for short RSIs) and "subjective expectancy" (i.e., a first-order alternation effect and a higher order cost-benefit pattern for long RSIs). Automatic facilitation was more pronounced for incompatible responses than for compatible responses. Both experiments showed the anticipated decrease in automatic facilitation with advancing age. Finally, the first-order alternation effect showed the predicted age-related increase, but the cost-benefit pattern revealed an opposite trend, suggesting that the first-order and higher order indexes of subjective expectancy may relate to dissociable mechanisms.

Adolescent↗

PubMed2004

Age-related changes in the efficiency of cognitive processing across the life span.

The global-speed and the specific-gain/loss hypotheses have been dominant theoretical frameworks in the recent literature on cognitive development and aging. Few attempts have been made to explicitly assess the predictive power of the two frameworks against each other. We evaluated the extent to which age changes in performance in executive function tasks (involving response selection, response suppression, working memory, and adaptive control) depend on age-related changes in global information-processing speed. Our sample consisted of children, adolescents, adults and seniors. Analysis of covariance and structural equation modeling revealed a mixed pattern of results. Controlling for global speed removed the child vs. adult differences in the speed of responding on the executive function tasks but the senior vs. adult differences remained. This mixed pattern of findings was interpreted to suggest that the effects of advancing age on the speed of responding are mediated by a global mechanism during childhood but during senescence the efficiency of executive functioning seems particularly vulnerable to the effects of age.

Adolescent↗

PubMed2004

Age-related changes in antisaccade task performance: inhibitory control or working-memory engagement?

In antisaccade tasks, subjects are required to generate a saccade in the direction opposite to the location of a sudden-onset target stimulus. Compared to young adults, older adults tend to make more reflex-like eye movements towards the target, and/or show longer saccadic onset latencies on correct direct antisaccades. To better understand the nature of these effects of aging on antisaccade performance, we examined the role of age-related deficiencies in inhibitory control vis-a-vis age changes in the engagement of working memory. Inhibitory demands were manipulated using fixation-offset conditions, while working-memory demands were manipulated by varying memory-updating requirements. The results indicate that inhibitory oculomotor functions remain largely intact with advancing age; older adults' performance breaks down only when their limited working-memory capacity is taxed by increasing updating demands.

Adolescent↗

PubMed2004

Additive factors analysis of inhibitory processing in the stop-signal paradigm.

This article reports an additive factors analysis of choice reaction and selective stop processes manipulated in a stop-signal paradigm. Three experiments were performed in which stimulus discriminability (SD) and stimulus-response compatibility (SRC) were manipulated in a factorial fashion. In each experiment, the effects of SD and SRC were assessed first for going and next for stopping. Two experiments yielded the anticipated additive relation between SD and SRC for going but stopping appeared to be insensitive to the SD manipulation. Increasing the SD demands in the third experiment by using a different display resulted in a significant (over-additive) interaction between SD and SRC for going and a non-significant (under-additive) interaction for stopping. The pattern of results that emerged from this set of experiments was interpreted to suggest that going and stopping are both similar and different. They are similar in that distinct stages can be identified in both going and stopping but they are also different, as selective stopping seems to be less sensitive to discrimination manipulations relative to going.

Adult↗

PubMed2004

Phasic heart rate responses to performance feedback in a time production task: effects of information versus valence.

This study examined the cardiac concomitants of feedback processing in a time production task derived from [Mittner et al., J. Cogn. Neurosci. 9 (1997) 788]. Participants performed the time production task (i.e. 1-s intervals) under two conditions. In the experimental condition, feedback informed them that the produced interval was within or outside the acceptable range (too long or too short). In the other, yoked-control, condition feedback was unrelated to the actual estimate. The performance findings indicated that in the experimental condition, participants tended to adjust the new interval in the direction indicated by the feedback. In the control condition, however, the adjustments were largely unrelated to the information provided by the feedback. Heart rate slowed to feedback stimuli indicating that the estimate was outside the acceptable range. Surprisingly, cardiac slowing did not discriminate between experimental and control conditions. This finding seems to suggest that heart rate is sensitive to the valence rather than the information provided by the feedback. This finding is discussed vis-à-vis current neuroimaging and psychophysiological studies of performance monitoring.

Adolescent↗

PubMed2004

Developmental trends in simple and selective inhibition of compatible and incompatible responses.

This study examined age-related change in the ability to inhibit responses using two varieties of the stop signal paradigm. Three age groups (29 7-year-olds, 24 10-year-olds, and 28 young adults) performed first on a visual choice reaction task in which the spatial mapping between the go signal and response was varied between blocks. The choice task was then complicated by randomly inserting a visual stop signal on 30% of the trials. In the simple stop signal paradigm, the stop signal required the inhibition of the planned response. In the selective stop signal paradigm, the stop signal required response inhibition only when the stop signal was presented at the same side as the instructed response to the go signal. The results showed that simple stopping was faster than selective stopping and that selective, but not simple, stopping of incompatible responses was slower than stopping of compatible responses. Brinley plot analysis yielded linear functions relating children's latencies to adults' latencies. Analysis of shared variance indicated that developmental change in the speed of selective stopping continued to be significant even when the effect associated with simple stopping was removed. This pattern of findings is discussed vis-à-vis notions of global versus specific developmental trends in the speed of information processing.

Adult↗

PubMed2004

Switching between spatial stimulus-response mappings: a developmental study of cognitive flexibility.

Four different age groups (8-9-year-olds, 11-12-year-olds, 13-15-year-olds and young adults) performed a spatial rule-switch task in which the sorting rule had to be detected on the basis of feedback or on the basis of switch cues. Performance errors were examined on the basis of a recently introduced method of error scoring for the Wisconsin Card Sorting Task (WCST; Barcelo & Knight, 2002). This method allowed us to differentiate between errors due to failure-to-maintain-set (distraction errors) and errors due to failure-to-switch-set (perseverative errors). The anticipated age differences in performance errors were most pronounced for perseverative errors between 8-9 years and 11-12 years, but for distraction errors adult levels were not reached until 13-15 years. These findings were interpreted to support the notion that set switching and set maintenance follow distinct developmental trajectories.

Adolescent↗

PubMed2004

Developmental changes in real life decision making: performance on a gambling task previously shown to depend on the ventromedial prefrontal cortex.

Patients with bilateral lesions of the ventromedial prefrontal cortex, when performing gambling tasks modeling real-life decision-making, opt for choices that yield high immediate gains in spite of higher future losses. Under the hypothesis that the prefrontal cortex is the last brain region to mature, it was examined whether young children would show a similar preference for immediate prospects. In Experiment 1, 4 age groups (6-9, 10-12, 13-15 and 18-25 years olds) performed 2 versions of a computerized variant of the original Iowa gambling task under 3 different feedback conditions (no feedback, global feedback, and option-specific feedback) and completed the Raven Standard Progressive Matrices as an index of inductive reasoning ability. In Experiment 2, 3 age groups (7-8, 11-12, and 15-16 year olds) performed both task versions in addition to a working memory task ("Digit Span Backwards"). Results showed a developmental increase in the sensitivity to future consequences, positive or negative, that could not be explained by developmental changes in working memory capacity or inductive reasoning. It was concluded that young children share with ventromedial prefrontal patients the failure to anticipate on future outcomes.

Adolescent↗

PubMed2003

Speed-accuracy modulation in case of conflict: the roles of activation and inhibition.

This study investigated how the speed-accuracy balance is modulated by changes in the time course of motor activation and inhibition of a primed response. Responses and event-related brain potentials were recorded in a paradigm in which the first stimulus indicated the correct response with 80% validity. The remaining 20% of the trials required no response (no-go) or a response opposite to the cued hand (change trials). Subjects were instructed either to balance speed and accuracy or to emphasize speed at the cost of accuracy. Analyses of error patterns, reaction time distributions and brain potentials show that subjects can modulate the amount of activation of the primed response. More surprisingly, the engagement of inhibition of the response also varied with the speed-accuracy instruction. The results are consistent with a model where the frontothalamic loop actively controls both the activation and the inhibition of responses, depending on the current task requirements.

Adult↗

PubMed2003

Horse-race model simulations of the stop-signal procedure.

In the stop-signal paradigm, subjects perform a standard two-choice reaction task in which, occasionally and unpredictably, a stop-signal is presented requiring the inhibition of the response to the choice signal. The stop-signal paradigm has been successfully applied to assess the ability to inhibit under a wide range of experimental conditions and in various populations. The current study presents a set of evidence-based guidelines for using the stop-signal paradigm. The evidence was derived from a series of simulations aimed at (a) examining the effects of experimental design features on inhibition indices, and (b) testing the assumptions of the horse-race model that underlies the stop-signal paradigm. The simulations indicate that, under most conditions, the latency, but not variability, of response inhibition can be reliably estimated.

Animals↗

PubMed2003

The duration of response inhibition in the stop-signal paradigm varies with response force.

In a previous study, we have found that the speed of stopping a response is delayed when response readiness is reduced by cuing the probability of no-go trials [Acta Psychol. 111 (2002) 155]. Other investigators observed that responses are more forceful when the probability to respond is low than when it is high (e.g. [Quart. J. Exp. Psychol. A 50 (1997) 405]). In this study, the hypothesis was tested that low probability responses are more forceful than high probability responses and that these responses are more difficult to stop. Subjects performed on a choice reaction task and on three tasks with respectively 100%, 80%, and 50% response probabilities. Stop signals were presented on 30% of the trials, instructing subjects to withhold their response. Response force on non-signal (go) trials and the duration of response inhibition on signal (stop) trials increased as response probability decreased. This pattern of findings was interpreted to support the hypothesis predicting that stopping is more difficult when response readiness is low than when it is high.

Adult↗