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Biomedical subjects

Max Fink

Publications and source records attributed to Max Fink.

At least 37 records · Page 2Linked to original sources

Rat Brain Concentration of Fluphenazine During a Course of Electroconvulsive Shock.

The brain concentration of fluphenazine was measured in two groups of rats, one treated with fluphenazine and electroconvulsive shock, and the other with fluphenazine only. No difference was found in brain fluphenazine concentration between the two groups. The experiment was replicated with a larger number of rats and the same result was obtained. Electroconvulsive shock does not increase the concentration of fluphenazine in brain tissue.

Journal Article↗

A Neuroendocrine View of ECT.

A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptide antidepressin-the active principle that relieves both neuroendocrine and behavioral abnormalities.

Journal Article↗