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Biomedical subjects

Maxim V Trushin

Publications and source records attributed to Maxim V Trushin.

12 recordsLinked to original sources
PubMed2007

Acholeplasma laidlawii PG8 culture adapted to unfavorable growth conditions shows an expressed phytopathogenicity.

Mycoplasmas are the smallest, self-replicating, prokaryotic organisms with avid biochemical potential and spreading in higher eukaryotes in nature. In this study, Acholeplasma laidlawii PG8 cells were cultivated on a deficient medium for 480 days resulting in a mycoplasma culture that was adapted in vitro to unfavorable growth conditions. Cells that survive this condition had decreased sizes (about 0.2 microm) and increased phytopathogenicity. This resulted in more frequent appearance of various morphological alterations when plants of vinca (Vinca minor L.) were infected by adapted mycoplasma cells. The increasing pathogenicity was accompanied by changes in genome expression in these adapted cells. Further studies are needed to explore the exact mechanisms that permit adaptation to unfavorable growth conditions and changes in phytopathogenic potential.

Acholeplasma laidlawii↗
PubMed2005

Antitumor features of Bacillus oligonitrophilus KU-1 strain.

Chemotherapy and radiotherapy remain mostly palliative methods for metastatic cancer treatment. Limitations in efficacy and safety of established treatments continue to underline the need for improved treatments for malignancy. Results with some probiotics with antitumor activity have been promising. Here, we report that oral reception of Bacillus oligonitrophilus KU-1 resulted in the prolongation of lives in cancer patients with terminal prognosis and stabilization of cancer growth. The theoretical basis for the phenomena observed is discussed.

Adult↗
PubMed2005

Variability of the Vaa cytoadhesin genes in clinical isolates of Mycoplasma hominis.

The Mycoplasma hominis vaa gene encodes a highly variable surface antigen involved in adhesion to host cells. We studied 15 clinical isolates of Mycoplasma hominis with three types of the vaa gene. These vaa versions determine various forms of Vaa protein, which are characterized by different quantity and structure of homologous replaceable cassettes. Each cassette contains heptad repeats and sites for adherence. The differences on single nucleotides were observed in the primary sequences of the homologous modules of the vaa gene. A high frequency of nucleotide replacements in V module of the vaa gene (first and/or second position in codon) was determined. This region with various clusters of direct and indirect repeats of nucleotide sequences is incorporated into the area of the vaa gene. Amino-acid sequences corresponding to the hyper-variable region of the vaa gene are associated with the sections of coiled-coils and loops of Vaa. These bacterial regions involved in interaction with the host cell membranes could yield useful indications for more insights into the mechanism of mycoplasma persistence in humans.

Adhesins, Bacterial↗
PubMed2004

Light-mediated "conversation" among microorganisms.

Light emitted from a wide variety of microorganisms was considered previously as a waste product. However, it is becoming apparent that it might be involved in microbial communication. This paper presents information on such a novel mode of communication in different microorganisms.

Bacteria↗
PubMed2003

Studies on distant regulation of bacterial growth and light emission.

Reciprocal interactions of two Escherichia coli MC1061 cultures separated by a glass window were investigated. The growth parameters and light emission from these cultures were analysed. A link between light emission and the growth parameters was observed.

Bacteriological Techniques↗
PubMed2003

Culture-to-culture physical interactions causes the alteration in red and infrared light stimulation of Escherichia coli growth rate.

Escherichia coli MC1061 cells were irradiated at 660 and 900 nm, incubated in M9 and LB media with the use of a specially constructed device, and assayed for growth rate. There was a reduction of growth rate stimulation when the irradiated culture was cultivated jointly with the non-irradiated one. In the same time, the irradiated culture extended the invigorate effect on the non-irradiated one. It is proposed that the effects observed were mediated by culture-to-culture physical interactions.

Culture Media↗
PubMed2003

The possible role of electromagnetic fields in bacterial communication.

This paper presents a general review of the current knowledge regarding bacterial communication via electromagnetic fields. The possible role of ultraviolet, visible and infrared light, extremely high frequency and low frequency electromagnetic fields as well as sound waves is discussed. The probable mechanisms of remote microbial interactions are raised. Future trends in the area of microbiology are also viewed.

Acoustics↗
PubMedDate not supplied

Distant non-chemical communication in various biological systems.

Communication is a natural ability of all living systems. It is very likely that various types of communication were evolved during evolution. While the communication by means of chemicals, direct contact or via organs of sense is under intensive study for a long time, alternative ways of interaction are still considered debatable, This review covers the topic of physically mediated communication in various biological systems.

Acoustic Stimulation↗
PubMedDate not supplied

Effects of type II pyrethroids on Daphnia magna: dose and temperature dependences.

Environmental contamination with various insecticides remains an actual problem. In this connection, investigation of toxicologic hazard of insecticides is essential. In this work, effects of the type II pyrethroids (fenvalerate, cypermethrin and deltamethrin) on Daphnia magna were determined. It was found for the first time that not only low doses (up to 10(-12) M) of the above-mentioned chemicals but also extremely low doses (up to 10(-29) M) showed toxicological action on the invertebrates both at optimal (23 +/- 0.5 degrees C) and increased (28 +/- 0.5 degrees C) temperature. At higher temperature, toxic effects were more pronounced.

Animals↗