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Medha Tatke

Publications and source records attributed to Medha Tatke.

13 recordsLinked to original sources
PubMed2006

Histological analysis of lesions of the pineal region: a retrospective study of 12 years.

Various types of tumors and non-tumor lesions arise in the pineal region. This study summarizes the experience the authors have gained with 54 lesions of the pineal region over the last 12 years. Histology was analyzed in all cases. Out of these 54 cases, four were non-tumor lesions. Of the 50 tumors, pineal parenchymal tumors (PPTs) were most common (42% (21/54)), followed by gliomas (40% (20/54)). The PPTs were pineoblastomas (10/21), PPT of intermediate differentiation (7/21), and pineocytomas (4/21). The other tumors included germ cell tumors (4/54), meningiomas (2/54), craniopharyngiomas (2/54), and choroid plexus papilloma (1/54). The non-tumor lesions were epidermoid cysts (2/54), tuberculous abscess (1/54), and cysticercosis (1/54). Immunohistochemically, all the PPTs showed cytoplasmic positivity for synaptophysin. Glial fibrillary acidic protein (GFAP) stained only the reactive astrocytes in these tumors except two cases of pineoblastoma, which showed GFAP positivity in some tumor cells, indicating glial differentiation. There are very few studies of pineal lesions, and there is no study from India in the indexed literature.

Adolescent↗
PubMed2005

Isolated vitamin E deficiency with demyelinating neuropathy.

A 22-year-old man, with a past history of generalized tonic-clonic seizures treated with phenobarbital, presented with spinocerebellar ataxia. The electrophysiological studies revealed a demyelinating motor-sensory neuropathy. The serum vitamin E level was low. Sural nerve biopsy revealed loss of large myelinated fibers with evidence of remyelination. Vitamin E supplementation led to clinical and electrophysiological recovery of sensory conduction and evoked potentials. Motor nerve conduction, however, showed only partial recovery. Vitamin E deficiency leading to a demyelinating neuropathy, as in the present case, suggests that the full spectrum of the disease entity is not fully defined.

Adult↗
PubMed2005

Beta-sarcoglycanopathy.

Sarcoglycanopathies are relatively rare progressive muscular dystrophies with autosomal recessive inheritance; which belong to the group of limb girdle muscular dystrophies. The phenotype resembles dystrophinopathies due to proximal muscle weakness and calf hypertrophy. Reports from the Indian subcontinent are scarce. The authors report a case of primary beta-sarcoglycanopathy and describe literature pertaining to this rare entity.

Child, Preschool↗
PubMed2005

Recurrent tumefactive demyelination in a child.

A 13-year-old female presented with two episodes of hemiplegia and hemianopia involving opposite sides, each time associated with seizures. On both occasions, the magnetic resonance (MR) scan showed a giant demyelinating, peripherally enhancing lesion with mass effect. MR spectroscopy (MRS) was indistinguishable from a tumor. At the first episode, she had undergone tumor decompression but the histopathology revealed an acute demyelinating lesion with no evidence of tumor. Each time there was partial clinical recovery and resolution of the radiological lesion, the patient having received corticosteroids during both of the episodes. She also developed hemiballismus postoperatively which resolved on withdrawing phenytoin. It is suggested that a trial of corticosteroids be given in suspected tumefactive demyelinating lesions, although they may be indistinguishable from a tumor.

Adolescent↗
PubMed2005

Cerebellar liponeurocytoma--a case report.

Cerebellar liponeurocytomas have been included in the 2000 classification of tumours of the central nervous system, under the heading of glioneuronal tumours. The tumour has two populations of cells- one composed of cells with morphology of neurocytes and the other are lipidised cells which look like mature fat cells. The tumour occurs in adults and has a good prognosis. Less than fifteen cases have been reported in world literature. We report a case of this rare tumour entity in a 32 years old female patient.

Adult↗
PubMed2003

Lumbar spinal meningeal melanocytoma of the l3 nerve root with paraspinal extension: a case report.

STUDY DESIGN: A case report of spinal meningeal melanocytoma with a dumbbell-shaped extension and its magnetic resonance imaging features is presented. OBJECTIVE: To present a rare spinal tumor with pathologic and radiologic features. SUMMARY OF BACKGROUND DATA: Meningeal melanocytomas are rare lesions usually found in the posterior fossa and upper cervical spine. The review of literature shows the variation in different studies. The characteristic magnetic resonance imaging features of meningeal melanocytoma have not yet been defined. METHODS: A 33-year-old woman presented with a 3-year history of backache and weakness of her left lower limb. Magnetic resonance imaging showed a large dumbbell tumor at L3-L4 with extension in the paraspinal region. Schwannoma was the first possibility suggested by the MRI features. Histopathology of the lesion showed a meningeal melanocytoma. RESULTS: The patient showed a significant recovery after surgery and a full course of radiotherapy. CONCLUSIONS: Radiologic presentation could be confusing in cases of spinal dumbbell-shaped tumors. Awareness of the lesion characteristics will facilitate diagnosis and treatment of this condition.

Adult↗
PubMed2002

Petrous apex arachnoid cyst extending into Meckel's cave.

A rare case of arachnoid cyst involving the petrous apex with an unusual clinical presentation has been described with special emphasis in the imaging features and importance of accurate presurgical diagnosis. Differentiation from the other benign lesions involving the petrous apex and the role of newer MR techniques in the diagnosis of these lesions has been highlighted.

Arachnoid Cysts↗
PubMed2002

Suprasellar cystic meningioma: unusual presentation and review of the literature.

We report on a case of suprasellar cystic meningioma. The magnetic resonance imaging of this tumor resembled that of a craniopharyngioma. The definitive diagnosis of meningioma was made only after histopathological confirmation. We conclude that preoperative studies are often equivocal. The possibility of meningioma should be considered in the diagnosis of any intracranial neoplasms with radiological and surgical evidence of a cystic lesion.

Central Nervous System Cysts↗
PubMed2002

Intramedullary arachnoid cyst. Case report.

The authors present an unusual case of intramedullary arachnoid cyst diagnosed in a patient after the lesion was resected. A wide decompressive surgery was performed and the lesion removed. Histopathological findings were consistent with the diagnosis of arachnoid cyst. Postoperatively the patient exhibited marked improvement in neurological status. To the best of the authors' knowledge, there is no case report of intramedullary arachnoid cyst reported in the literature. With the advent of newer neuroimaging modalities such as magnetic resonance imaging the number of cases of intramedullary arachnoid cysts encountered in the future may increase.

Arachnoid Cysts↗
PubMed2002

Histological analysis of cystic tumour like lesions of central nervous system.

True cysts of the central nervous system (CNS) are rare lesions. A retrospective study of patients with symptomatic non-neoplastic cystic lesions of CNS operated in the Department of Neurosurgery, G.B. Pant Hospital, New Delhi between Jan 1994 and Feb 2001 was conducted. Parasitic cysts, cystic transformation of hemmorhages, vascular malformations and cystic tumours were excluded from the study. A total of 109 cases were reviewed. There were 34, 27, 17, 16, 8, 3 and 2 cases of epidermoid, arachnoid, dermoid, colloid, neurenteric, Rathke's and ependymal cysts and 1 case each of choroid plexus and glial cysts. The clinical presentations, locations, incidence and pathogenesis of these cysts is discussed.

Central Nervous System Neoplasms↗
PubMedDate not supplied

Histological spectrum of ependymomas and correlation of p53 and Ki-67 expression with ependymoma grade and subtype.

BACKGROUND: Clinical and histological criteria for ependymoma prognosis are well recognized. Recently few studies have been done based on Immunohistochemistry for prognostication of these tumours. In this study we have correlated the histological spectrum with immmunoexpression of p53 and Ki67 in these tumors. AIMS: To know the incidence of ependymomas; study their morphological spectrum and to evaluate expression of P53 and Ki 67 in different morphological subtypes. MATERIAL AND METHOD: A retrospective study was preformed on 70 ependymomas received in a period between 1994 and 2001. Entire tissue received was processed for routine paraffin embedded H&E stained sections. Immunocytochemistry was performed using antibodies to GFAP, EMA, Pancytokeratin and synaptophysin, to differentiate papillary ependymoma from choroid plexus papilloma; clear cell ependymoma from oligodendroglioma and central neurocytoma; ependymoblastoma from other embryonal tumours. p53 and Ki-67 immunohistochemistry was performed to correlate their expression with various tumour grades and subtypes. RESULTS: There were 3 cases (4.2%) of Grade I ependymoma (2 cases of myxopapillary ependymoma and 1 case of subependymoma); 57 cases (81.5%) of ependymoma grade II (43 of these were of classical variety, 11 of clear cell ependymoma, 2 of papillary and 1 case of cellular ependymoma). There were 9 cases (12.8%) of anaplastic ependymoma (one of these was a clear cell ependymoma and 1 case (1.5%) of ependymoblastoma CONCLUSION: p53 and Ki67 indices can be used in routine diagnostic laboratories to supplement the tumor grade on histology and more studies with follow up should be performed to analyse the prognosis of different subtypes. The expression of Ki 67 and p53 was significantly higher in anaplastic ependymomas. 4 out of 11 cases of clear cell ependymomas showed higher Ki 67 indices as compared to classical grade II ependymomas, thus further highlighting the importance of differentiating the various subtypes.

Adolescent↗