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Biomedical subjects

Mehmet Ates

Publications and source records attributed to Mehmet Ates.

At least 19 recordsLinked to original sources
PubMed2006

Evaluation of risk factors associated with femoral pseudoaneurysms after cardiac catheterization.

BACKGROUND: Femoral pseudoaneurysm (FPA) is one of the common complications of percutaneous catheterization procedures performed via the femoral artery. The aim of this research was to evaluate factors associated with FPA of sufficient clinical significance that they required surgical treatment after diagnostic or interventional cardiac catheterization. METHODS: We evaluated 41,322 transfemoral catheterization procedures performed in our center within 7 years. Among all procedures, 630 FPAs developed that required surgical repair. Eighty-five cases were managed by compression with duplex guidance. As a case-control group, 1260 patients were selected from the patients who had been catheterized during the same time period but did not develop FPA. Two controls were selected for each study patient, matched according to age, sex, and catheterization day. Body mass index, hypertension, diabetes mellitus, catheter diameter, coronary artery disease, atherosclerosis, and number of cases performed per day in a particular room were evaluated as risk factors by using multivariate techniques. RESULTS: Femoral pseudoaneurysm required operative repair in 1.1% (n = 398) of patients who underwent cardiac catheterization for diagnostic purposes and in 4.7% (n = 232) of patients after cardiac interventional procedures. Factors found to be independently predictive of FPA were hypertension (P = .011; odds ratio, 1.52), diabetes mellitus (P = .035; odds ratio, 1.11), coronary artery disease (P = .022; odds ratio, 1.21), larger (> or = 28 kg/m2) body mass index (P < .001; odds ratio, 2.21), larger number of cases (> or = 18) performed per day in a particular room (P < .001; odds ratio, 2.39), and larger (> or = 7F) catheter diameter (P < .001; odds ratio, 2.82). CONCLUSIONS: Due to the development of technology and experience, more and more diagnostic and interventional catheterization procedures are performed on a daily basis. In our study, a high volume of cases in a particular room and use of large catheters were important risk factors for FPA complications. When these situations are combined with other risk factors (such as obesity, diabetes mellitus, hypertension, and arteriosclerosis), giving particular attention to local compression therapy would be more crucial to decrease the FPA rate.

Aneurysm, False↗
PubMed2006

Is single or double aortic clamping safer in terms of cerebral outcome during coronary bypass surgery?

The purpose of the present study was to investigate retrospectively which aortic clamping technique, the single clamp technique (SCT) or double clamping technique (DCT), is safer in terms of cerebral functions in patients who have undergone coronary bypass surgery. We evaluated 1100 patients who underwent coronary artery bypass graft surgery at our institute from 1998 to 2004. The two groups, SCT (n = 550, 50%) and DCT (n = 550, 50%), were comparable with respect to smoking, hypertension, hypercholesterolemia, diabetes mellitus, chronic obstructive pulmonary disease, peripheral arterial disease, history of neurological events, creatinine levels, and existence of a carotid lesion. No significant differences between the SCT and DCT groups were observed in terms of cardiac and cerebral complications perioperatively and postoperatively. Both single and double clamping techniques have advantages and disadvantages in patients undergoing coronary bypass surgery.

Aged↗
PubMed2006

Giant left atrium with rheumatic mitral stenosis.

A chest radiograph of a 38-year-old woman, who was diagnosed with rheumatic mitral stenosis, revealed cardiac enlargement due to a giant left atrium that was distorting the cardiac structures. The patient's cardiothoracic ratio was approximately 0.90. A giant left atrium can readily be delineated by echocardiography. Optimal timing of surgery is important in cases of mitral stenosis, because delaying mitral valve replacement can lead to fatal outcomes. To our knowledge, the left atrial diameter of 18.7 cm that we found in our patient is the largest reported to date.

Adult↗
PubMed2005

Right ventricle hydatid cyst requiring tricuspid valve excision.

Hydatid cyst in the heart is uncommon, with cardiac involvement occurring in about 0.4-2% of all hydatid infestations. The right ventricle is only rarely involved accounting for 8% of cases. We report a case of a hydatid cyst located in the right ventricle involving the posterior papillary muscle requiring tricuspid valve excision.

Cardiomyopathies↗
PubMed2005

Surgical treatment of left-sided prosthetic valve thrombosis: short and long-term results.

We report a single center experience of surgical treatment of 30 cases of left-sided prosthetic valve thrombosis (PVT). In our series, a diagnosis of PVT was established based on clinical and echocardiographic examinations. Thrombosis was the major etiologic factor in 25 patients (83.3%), while 22 of 25 patients (88%) had a subtherapeutic anticoagulation level. The early hospital mortality rate was 7.1% in patients with New York Heart Association (NYHA) functional classes II - III, and 31.3% in NYHA functional class IV. The median interval from the surgical procedure to follow-up for these patients was 29.2 months. No recurrence or deaths were observed during 3 to 73 months following the surgical procedure.

Adult↗
PubMed2005

Influence of different echocardiographic imaging modes on the assessment of anterior mitral leaflet thickness.

BACKGROUND AND AIM OF THE STUDY: The study aim was to compare fundamental imaging (FI) measurements with harmonic imaging (HI) measurements and surgical measurements (SM) in the assessment of mitral anterior leaflet thickness. METHODS: Forty-three patients scheduled to undergo mitral valve replacement were included. Before surgery, routine echocardiography was performed in all patients using an instrument fitted with a 2.5 MHz broadband transducer. The anterior mitral leaflet was measured with different echocardiographic imaging modalities, and also surgically. During FI, the transducer transmission frequencies were 2.5 MHz and 2 MHz, while transmission frequencies of 1.7 MHz and 1.5 MHz were used during HI. Surgical measurements were taken immediately after surgery from a mitral valve specimen that was removed intact. RESULTS: Mitral anterior leaflet thickness measurements derived from FI at 2 MHz transmission frequency (3.8 +/- 1.1 mm, p = 0.020), HI at 1.7 MHz (4.4 +/- 1.2 mm, p < 0.001), and HI at 1.5 MHz (4.5 +/- 1.2 mm, p < 0.001) were significantly larger than those made surgically (3.3 +/- 0.6 mm). However, no significant differences were seen between thickness measurements derived from FI at 2.5 MHz transmission frequency and SM (3.7 +/- 1 mm versus 3.3 +/- 0.6 mm, p = 0.063). Mitral anterior leaflet thickness was greater with HI than with FI (1.7 MHz versus 2.5 MHz, p < 0.001; 1.7 MHz versus 2 MHz, p < 0.005; 1.5 MHz versus 2.5 MHz, p < 0.001; 1.5 MHz versus 2 MHz; p < 0.002). The closest measurement to SM was that obtained at a transmission frequency of 2.5 MHz (mean difference 0.3 +/- 0.6 mm; SEE 0.1 mm). CONCLUSION: Mitral anterior leaflet thickness measurements made with HI appear to be greater than those made with either FI or SM.

Adult↗
PubMed2003

Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.

Calcitonin gene related peptide (CGRP) is involved in nociceptive transmission and modulation at the spinal level. In the spinal superperfusion model, Delta(9) tetrahydrocannabinol inhibited capsaicin induced CGRP release in a concentration dependent manner. Similarly, flurbiprofen (3 microM) inhibited spinal CGRP release. This inhibition was reversed by the CB(1) antagonist AM-251 (1 microM), but not by co-administration of prostaglandin E(2) (PGE(2); 285 nM). AM-251 had no modulatory effect on flurbiprofen-induced cyclooxygenase (COX) inhibiting capacity as shown by PGE(2) levels. Furthermore, the phospholipase A(2) inhibitor palmityl trifluromethyl ketone (15 microM) reversed flurbiprofen's inhibitory effect. In conclusion the present work provides evidence on the shift of arachidonic acid metabolism towards endocannabinoids formation in response to COX inhibition as a mechanism for flurbiprofen inhibitory effect on spinal CGRP release.

Animals↗
PubMed2003

Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test.

It is generally accepted that the phospholipase-A2-cyclooxygenase-prostanoids-cascade mediates spinal sensitization and hyperalgesia. However, some observations are not in line with this hypothesis. The aim of the present work was to investigate whether different components of this cascade exhibit nociceptive or antinociceptive effects in the rat formalin test. Intrathecal (i.th.) injection of prostaglandin E2 (PGE2) induced a dose-dependent antinociceptive effect on the formalin-induced nociception. Furthermore, thimerosal, which inhibits the reacylation of arachidonic acid thereby enhancing arachidonic acid levels, had an antinociceptive effect rather than the expected pronociceptive effect when given i.th. While the phospholipase A2 inhibitor methyl arachidonyl fluorophosphonate (MAFP; i.th.) had a significant antinociceptive effect, its analogue palmitoyl trifluoromethyl ketone (PTFMK; i.th.) had no significant effect on the formalin-induced nociception. However, MAFP, but not PTFMK, showed a cannabinoid CB1 agonistic effect as shown by the inhibition of electrically evoked contractions of the vas deferens isolated from CB1 wild-type mice but not of that from CB1 knockout mice. The antinociceptive effect of MAFP was completely reversed by the CB1 receptor antagonist AM-251 (i.th.), thus attributing such effect to its CB1 agonistic effect. Moreover, the antinociceptive effect of the cyclooxygenase inhibitor, flurbiprofen (i.th.) was reversed by the co-administration of AM-251, but not by PGE2. Finally. the combination of phenylmethylsulfonyl fluoride (PMSF; intraperitoneal), which inhibits the degradation of anandamide through the inhibition of fatty acid amidohydrolase, with thimerosal (i.th.) produced a profound CB1-dependent antinociception. The present results show that endocannabinoids play a major role in mediating flurbiprofen-induced antinociception at the spinal level.

Analgesics↗