Biomedical subjects

Menghe Guo

Publications and source records attributed to Menghe Guo.

5 recordsLinked to original sources

PubMed2005

[Cat-scratch disease].

OBJECTIVE: To study the etiology, epidemiology, clinical and pathological features, diagnose and treatment of cat-scratch disease(CSD). METHOD: The clinical information of 1 case was reported and the literatures were also reviewed. RESULT: Bartonella henselae was the primary pathogen of CSD. Almost all patients with CSD were in contact with animals, especially cat or dog before the occurrence of the disease. All the patients had the self-limited swelling of local lymph nodes and commonly a fever. The pathological feature was necrotic granulation-like micro abscessation, and a pleomorphous argyrophil G- bacillus could be showed by Warthin-Starry or Brown-Hopp stainings in the swelling lymph nodes. CONCLUSION: CSD is a self-limited bacterial infectious disease. And its clinical features,biopsy and special stainings of swelling lymph nodes are helpful to the final diagnosis. Gentamicin, rifadin, ciprofloxacin, clarithromycin, bactrim, mitramycin, or resection of swelling lymph nodes had good effects on treating CSD.

Bartonella henselae↗

PubMed2004

[Characteristic of distortion product otoacoustic emissions for preterm newborn].

OBJECTIVE: To investigate the characteristic of distortion product otoacoustic emissions (DPOAE) amplitude, SNR and noise in preterm newborns. METHOD: DPAOEs at the 2f1-f2 frequency were recorded from 59 ears of 31 preterm newborns and 35 ears of 19 healthy fullterm newborns in response to equilevel primary tones at postnatal 3 days to 1 week. Detailed test included the recording of DPAOEs, SNR and noise. RESULT: The average DPOAE audiogram of preterm newborns illustrating the frequency response of these emissions demonstrated a maximum at 1,587 Hz and a minimum around 4,000 Hz. The DPOAE response amplitude of preterm newborn was lower than that of fullterm in every frequency(P < 0.05). The SNR was higher at 4,000 Hz than that at low frequency, but was lower at 1000 Hz than that at high frequency. At 4,000, 3,175, 1,587, 1,260 and 1,000 Hz, the SNR of preterm were lower thad fullterm(P < 0.05). The noise was higher at low frequency than that at high frequency. CONCLUSION: The characteristics of DPOAE in preterm newborn are different from fullterm newborn. These differences may indicate immaturity in cochlear function. Outer hair cell function are hypothesized sources of this immaturity, although some contribution from the immature middle ear and outer ear cannot be ruled out.

Acoustic Stimulation↗

PubMed2003

[Treatment of operation of carotid body tumor and glomus jugular tumor].

OBJECTIVE: To study the clinical characteristics and outline of surgery for carotid body tumor and glomus jugular tumor. METHOD: Incisions of anterior border of sterno-mastoid muscle was made for simple carotid body tumor. A big S shape incisions and infratemporal fossa approach were employed which exposure the jugular foramen and apex of petrous for glomus jugular tumor or suffered carotid body tumor and glomus jugular tumor simultaneously in same side. RESULT: Five cases of carotid body tumor were removed thoroughly and the internal carotid artery were intact reserved. In 5 cases of glomus jugular tumor 3 cases were removed thoroughly, other 2 cases of glomus jugular tumor were palliative operation, the remnant tumor have not increased in size after 1 to 3 years follow up. CONCLUSION: Chemodectoma have some genetic characteristic. Surgical intervention is the cardinal method of treatment.

Adult↗

PubMed2002

[Down-regulation of telomerase and its RNA and apoptosis in the HNE1 cell line of nasopharyngeal carcinoma induced by retinoid].

OBJECTIVE: To explore the down-regulation of telomerase as well as its RNA and apoptosis induced by retinoid acid. METHOD: After HNE1 cell lines of NPC were incubated with 10(-5) mol of retinoid in 6 days, the expression of telomerase and its RNA and the apoptosis of HNE1 cell lines were detected respectively with TRAP PCR ELISA, RT-nested PCR, apoptosis indexes and trans-electron microscope. RESULT: After 6 days when RA was added to the HNE1 cell line, the morphological change and suspending of HNE1 cells were found and the HNE1 cells reduced. Meanwhile, the expression of telomerase and hTR was obviously inhibited and the telomerase activity was only the 1/2 of the control with the use of ELISA indirect quantitative assay. Apoptosis indexes and apoptosis cells in RA groups were higher than those in control (P < 0.05). CONCLUSION: The expression of telomerase and hTR are obviously inhibited and the apoptosis of HNE1 cell lines is also induced by retinoid.

Apoptosis↗

PubMedDate not supplied

In vivo micromechanical measurements of the organ of Corti in the basal cochlear turn.

Cochlear mechanical measurements of organ of Corti motion are generally accomplished in the apical or basal turn as in vivo or in vitro studies. In the apex it is possible to observe and measure tectorial membrane vibration as well as vibrations of structures such as the reticular lamina or the basilar membrane (BM). However, compared to the basal turn, cochlear amplification and nonlinearity are not strong in the apex. Basal turn studies have typically been limited to point location measurements of the BM but improved technology for laser interferometry is now making possible the spatial mapping of BM motion. The 'complexity' of BM motion in the radial direction (particularly the phase variation) is important to new models of cochlear wave amplification. In future work it may be possible to learn about vibration of structures within the organ of Corti.

Animals↗