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Merryn H Tawhai

Publications and source records attributed to Merryn H Tawhai.

10 recordsLinked to original sources
PubMed2006

Computational models of structure-function relationships in the pulmonary circulation and their validation.

The pulmonary airway, arterial, venous and capillary networks are vast complex branching and converging systems that are mechanically coupled to the surrounding lung tissue. Early studies that examined vascular or airway geometry relied on measurements from casts, but medical imaging now enables measurement of the lung in vivo, at controlled lung volumes. The high-quality data that imaging provides have prompted development of increasingly sophisticated models of the geometry of the airway and pulmonary vascular trees. The accurate spatial relationships between airway, vessel and tissue in these imaging-derived models are necessary for computational analysis that aims to elucidate regional airway-vessel-tissue interactions. Predictions of blood flow through multiscale imaging-derived models of the pulmonary arteries and capillary bed reveal geometry-dependent patterns of perfusion in response to gravity and lung orientation that cannot be predicted with simplified, summary representations of the pulmonary transport trees. Validation of such predictions against measures from functional imaging holds significant potential for explaining and differentiating normal and disease-related heterogeneity in regional blood flow calculated using perfusion imaging.

Computer Simulation↗
PubMed2006

An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung.

RATIONALE AND OBJECTIVES: A computational modeling framework of soft-tissue mechanics and air flow has been developed toward the aim of linking computed tomography measures of ventilation distribution to subject-specific predictions in imaging-based geometric models of the lung. The aim of this approach is to enable predictions of the effect of perturbations in geometry or functional parameters on imaged function of the lung. MATERIALS AND METHODS: Computational techniques that can deal with anatomic detail and spatially distributed nonlinear material properties are used to model parenchymal soft-tissue mechanics in a physically realistic model of the ovine lung. The lung is modeled as a homogeneous, compressible, nonlinearly elastic body. Using equations for large deformation mechanics, change in geometry of the lung is simulated at static inflation pressures from 25 cm H2O to 0 cm H2O. Multidetector row computed tomography imaging defines the model geometry, the movement of the model lung surface during inflation, and displacement of airway bifurcations for comparison with predicted internal displacements of the model. RESULTS: A novel modeling framework has been formulated that links equations for large deformation of the lung tissue to equations for airway flow and pressure. This preliminary model predicts airway displacements that are in good agreement with imaged displacements (total root mean square [RMS] error < 4 mm from 25 to 0 cm H2O). CONCLUSIONS: State-of-the-art computed tomography imaging is interpreted using a modeling framework to predict ventilation distribution and changes in the geometry of the lung during increments in inflation pressure. Further development will provide a predictive link between subject-specific anatomy and function.

Algorithms↗
PubMed2005

Computational predictions of pulmonary blood flow gradients: gravity versus structure.

A computational model of blood flow through the human pulmonary arterial tree has been developed to investigate the mechanisms contributing to regional pulmonary perfusion in the isolated network when the lung is in different orientations. The arterial geometric model was constructed using a combination of computed tomography and a volume-filling branching algorithm. Equations governing conservation of mass, momentum, and vessel distension, incorporating gravity, were solved to predict pressure, flow, and vessel radius. Analysis of results in the upright posture, with and without gravity, and in the inverted, prone, and supine postures reveals significant flow heterogeneity and a persistent decrease in flow in the cranial and caudal regions for all postures suggesting that vascular geometry makes a major contribution to regional flow with gravity having a lesser role. Results in the isolated arterial tree demonstrate that the vascular path lengths and therefore the positioning of the pulmonary trunk relative to the rest of the network play a significant role in the determination of flow.

Algorithms↗
PubMed2005

Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels.

Studies of the origin of pulmonary blood flow heterogeneity have highlighted the significant role of vessel branching structure on flow distribution. To enable more detailed investigation of structure-function relationships in the pulmonary circulation, an anatomically based finite element model of the arterial and venous networks has been developed to more accurately reflect the geometry found in vivo. Geometric models of the arterial and venous tree structures are created using a combination of multidetector row X-ray computed tomography imaging to define around 2,500 vessels from each tree, a volume-filling branching algorithm to generate the remaining accompanying conducting vessels, and an empirically based algorithm to generate the supernumerary vessel geometry. The explicit generation of supernumerary vessels is a unique feature of the computational model. Analysis of branching properties and geometric parameters demonstrates close correlation between the model geometry and anatomical measures of human pulmonary blood vessels. A total of 12 Strahler orders for the arterial system and 10 Strahler orders for the venous system are generated, down to the equivalent level of the terminal bronchioles in the bronchial tree. A simple Poiseuille flow solution, assuming rigid vessels, is obtained within the arterial geometry of the left lung, demonstrating a large amount of heterogeneity in the flow distribution, especially with inclusion of supernumerary vessels. This model has been constructed to accurately represent available morphometric data derived from the complex asymmetric branching structure of the human pulmonary vasculature in a form that will be suitable for application in functional simulations.

Adult↗
PubMed2005

Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model.

RATIONALE AND OBJECTIVES: A computational model of blood flow through the human pulmonary arterial tree has been developed to investigate the relative influence of branching structure and gravity on blood flow distribution in the human lung. MATERIALS AND METHODS: Geometric models of the largest arterial vessels and lobar boundaries were first derived using multidetector row x-ray computed tomography (MDCT) scans. Further accompanying arterial vessels were generated from the MDCT vessel endpoints into the lobar volumes using a volume-filling branching algorithm. Equations governing the conservation of mass and momentum were solved within the geometric model to calculate pressure, velocity, and vessel radius. Blood flow results in the anatomically based model, with and without gravity, and in a symmetric geometric model were compared to investigate their relative contributions to blood flow heterogeneity. RESULTS: Results showed a persistent blood flow gradient and flow heterogeneity in the absence of gravitational forces in the anatomically based model. Comparison with flow results in the symmetric model revealed that the asymmetric vascular branching structure was largely responsible for producing this heterogeneity. Analysis of average results in varying slice thicknesses illustrated a clear flow gradient because of gravity in "lower resolution" data (thicker slices), but on examination of higher resolution data, a trend was less obvious. CONCLUSIONS: Results suggest that although gravity does influence flow distribution, the influence of the tree branching structure is also a dominant factor. These results are consistent with high-resolution experimental studies that have demonstrated gravity to be only a minor determinant of blood flow distribution.

Blood Flow Velocity↗
PubMed2004

CT-based geometry analysis and finite element models of the human and ovine bronchial tree.

The interpretation of experimental results from functional medical imaging is complicated by intersubject and interspecies differences in airway geometry. The application of computational models in understanding the significance of these differences requires methods for generation of subject-specific geometric models of the bronchial airway tree. In the current study, curvilinear airway centerline and diameter models have been fitted to human and ovine bronchial trees using detailed data segmented from multidetector row X-ray-computed tomography scans. The trees have been extended to model the entire conducting airway system by using a volume-filling algorithm to generate airway centerline locations within detailed volume descriptions of the lungs or lobes. Analysis of the geometry of the scan-based and model-based airways has verified their consistency with measures from previous anatomic studies and has provided new anatomic data for the ovine bronchial tree. With the use of an identical parameter set, the volume-filling algorithm has produced airway trees with branching asymmetry appropriate for the human and ovine lung, demonstrating the dependence of the method on the shape of the lung or lobe volume. The modeling approach that has been developed can be applied to any level of detail of the airway tree and into any volume shape for the lung; hence it can be used directly for different individuals or animals and for any number of scan-based airways. The resulting models are subject-specific computational meshes with anatomically consistent geometry, suitable for application in simulation studies.

Algorithms↗
PubMed2004

Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network.

An anatomically based finite element model of the human pulmonary microcirculation has been created and applied to simulating regional variations in blood flow. A geometric mesh of the capillary network over the surface of a single alveolar sac is created using a Voronoi meshing technique. A pressure-flow relationship that describes blood cell transit is implemented in the network. Regional flow is investigated by imposing gravity-dependent transpulmonary and transmural boundary conditions. Comparisons of red and white blood cell transit times in the upper, mid, and lower lung showed physiologically consistent trends of a decreasing average transit time and an increased homogeneity of transit time distributions as a result of increasing average capillary diameter and flow down the height of a vertical lung. The model was found to reproduce experimentally consistent trends in red blood cell transit times and relative blood flows with respect to lung height. This model enables flow properties and cell transit time behavior in the pulmonary microcirculation under varying conditions, for example in different "zones" of the lung, to be explored.

Blood Flow Velocity↗
PubMed2004

Modeling water vapor and heat transfer in the normal and the intubated airways.

Intubation of the artificially ventilated patient with an endotracheal tube bypasses the usual conditioning regions of the nose and mouth. In this situation any deficit in heat or moisture in the air is compensated for by evaporation and thermal transfer from the pulmonary airway walls. To study the dynamics of heat and water transport in the intubated airway, a coupled system of nonlinear equations is solved in airway models with symmetric geometry and anatomically based geometry. Radial distribution of heat, water vapor, and velocity in the airway are described by power-law equations. Solution of the time-dependent system of equations yields dynamic airstream and mucosal temperatures and air humidity. Comparison of model results with two independent experimental studies in the normal and intubated airway shows a close correlation over a wide range of minute ventilation. Using the anatomically based model a range of spatially distributed temperature paths is demonstrated, which highlights the model's ability to predict thermal behavior in airway regions currently inaccessible to measurement. Accurate representation of conducting airway geometry is shown to be necessary for simulating mouth-breathing at rates between 15 and 100 l x min(-1), but symmetric geometry is adequate for the low minute ventilation and warm inspired air conditions that are generally supplied to the intubated patient.

Computer Simulation↗
PubMed2003

Developing integrative computational models of pulmonary structure.

Integrative computational modeling of the pulmonary system aims to incorporate interactions between the lung's subsystems by means of a hierarchy of structural and functional models. This requires detailed imaging-based data, along with a wide range of functional information from experiments. Advances in computed tomography imaging technology ensure that high-resolution data are now readily available upon which the structure of these models can be based. We present methods for constructing anatomically realistic finite element models of interrelated pulmonary structures from such data. Segmented human lung lobe data are fit to high-order (cubic Hermite) volume elements. Meshes for the conducting airways and pulmonary arteries and veins are constructed within the lobe mesh, using a combination of fitting to imaging data and a bifurcating-distributive algorithm. The algorithm generates an airway-consistent mesh within a host volume, and this airway mesh is then used as a template for generating blood vessel models. The lung parenchyma is modeled as a space-filling three-dimensional (3D) Voronoi mesh, with generated geometry consistent with the alveolated airway structure. Pulmonary capillaries are generated over the alveolar model, as a 2D Voronoi mesh. These structural models have been compared extensively with morphometric data to verify that their geometry is representative of the pulmonary system. The models are designed to be integrative: they relate multiple structural systems within the same individual, and their use as computational meshes allows application of spatially distributed properties.

Algorithms↗