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Michał Nowak

Publications and source records attributed to Michał Nowak.

2 recordsLinked to original sources
PubMed2006

A generic 3-dimensional system to mimic trabecular bone surface adaptation.

The paper presents the structure optimizing system based on surface remodelling. The grounds for algorithm formulation are given by the bone remodelling phenomenon leading to optimization of trabecular network in the bone. The assumptions, algorithms and limitations of the own mesh generator Cosmoprojector are described. Unlike other approaches, the system is able to mimic real bone evolution including tissue consolidation and separation. The article presents a closed system consisting of finite element mesh generation, decision criteria for structure adaptation and finite element analysis in parallel environment. It also provides some computation results obtained by using specially designed software.

Adaptation, Physiological↗
PubMed2005

[The role of retinal oxygen metabolism in origin of age-related macular degeneration (AMD)].

Age-related macular degeneration (AMD) is the leading cause of visual loss in individuals over 60 years old, in developed countries. This article provides the latest information about the role of retinal oxygen metabolism in origin of that disease. It is considered that reactive oxygen species (ROS), including free radicals are responsible for apoptotic cell death and developing of pathological changes in AMD. Exposure to visible light induces dysfunction of retinal pigment epithelial cells, accumulation of lipoprotein aggregates in Bruch's membrane, formation of drusen, and final results are damage to photosensitive retina, which leads to AMD. There are many of antioxidant systems in retina, which protect tissue from ROS. In this review we focus on their actions in terms of mechanisms of preventing oxidative damage and their potential role in therapy of AMD. There is strong evidence suggesting the supporting role of the nutritional antioxidant supplementation and protection from exposure to the visible light in the prevention and treatment of age-related macular degeneration.

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