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Michael Clark

Publications and source records attributed to Michael Clark.

30 records · Page 2Linked to original sources

Barriers to the implementation of clinical guidelines.

Clinical guidelines in wound care have recently been formulated at the national and international level, reflecting a shift from locally derived guidelines common during the 1990s. There remains considerable uncertainty regarding the extent of implementation and monitoring of these new guidelines. This paper presents the results of a survey of members of the Tissue Viability Society that sought their views upon the guidelines in place within their workplace--how were these guidelines developed, was the impact of guidelines monitored and how and finally what barriers limited their full implementation. Of the 1500 members, 476 returned completed questionnaires (34.0% response rate). Most (n = 422, 88.4%) worked within environments that implemented clinical guidelines in some aspect of wound care, with guidance upon pressure ulcer prevention being most commonly reported (n = 351). The use of national guidelines (either in their original format or locally modified to reflect local circumstances) was relatively common--reported by 307 of the 476 respondents. Few reported that guidelines were fully implemented (n = 77; 18.3%) with lack of resources, lack of awareness of the content of the guidelines and, when aware, lack of acceptance of their recommendations being the most commonly cited reasons for the failure to implement. However, it should be noted that only 34.0% of the surveyed population responded--this may question how far the results can be considered to reflect the current status of guideline implementation in the UK given the unreported views of 66% of all those surveyed.

Guideline Adherence↗

Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization.

PURPOSE: Traditionally, vaccines have been administered by needle injection. Topical immunization through the intact skin with either protein- or DNA-based vaccines has attracted much attention recently. We sought to enhance the immune responses induced by DNA-based vaccines after topical application by developing novel ethanol-in-fluorocarbon (E/F) microemulsion systems to aid in the delivery of plasmid DNA (pDNA). METHODS: Ten different fluorosurfactants were selected or synthesized and screened by pseudo-phase-diagram construction for their ability to form E/F microemulsions. Plasmid DNA was successfully incorporated into E/F microemulsions using several different fluorosurfactants and perfluorooctyl bromide as the continuous fluorocarbon phase. For several reasons, Zonyl FSN-100 (an ethoxylated nonionic fluorosurfactant) was selected for further studies. In vivo studies were performed in mice to assess pDNA expression in skin and immunologic responses after topical application of this system using a luciferase-encoding plasmid (CMV-luciferase) and a CMV-beta-galactosidase-encoding plasmid, respectively. RESULTS: Plasmid DNA incorporated into E/F microemulsion using FSN-100 as the surfactant was found to be stable. After topical application of this E/F microemulsion system, significant enhancements in luciferase expression and antibody and T-helper type-1 biased immune responses were observed relative to those of "naked" pDNA in saline or ethanol. For example, with the E/F microemulsion system, the specific serum IgG and IgA titers were increased by 45-fold and over 1000-fold, respectively. CONCLUSION: A novel fluorocarbon-based microemulsion system for potential DNA vaccine delivery was developed.

Administration, Topical↗

Improving the accuracy of pressure ulcer risk calculators: some preliminary evidence.

This study presents data from a prospective cohort study of 213 in-patient admissions of people over 65. Logit analysis was used to investigate the relative contribution of a range of risk factors to the risk of pressure ulcer occurrence, as a basis for development of improved risk assessment tools. It was found that for this population, a model containing the Waterlow risk factors appetite, continence, skin condition and age, plus diagnosis, performed better than one based on the complete set of Waterlow factors. Gender was not significant. A diagnosis of cancer was positively associated with pressure ulcer occurrence but presence of Parkinson's disease had the opposite effect.

Age Factors↗

The association of housing density, isolation and tuberculosis in Canadian First Nations communities.

BACKGROUND: First Nations communities in Canada experience disproportionately high levels of overcrowded housing, degree of isolation, and rates of tuberculosis (TB). A study was done to assess the association between housing density, isolation, and the occurrence of TB in First Nations communities. METHODS: Average persons per room (ppr), isolation type, average household income, population, and TB cases (1997-1999) at the community level were entered into a database. Tuberculosis notification rates and 95% CI were calculated for different strata of ppr and isolation. Two multiple logistic regression models were developed to examine the association of ppr, isolation, income, and population with the occurrence of >/=1, or >/=2, TB cases in a community. RESULTS: The rate was 18.9 per 100,000 (95% CI: 13.3-24.6) in communities with an average of 0.4-0.6 ppr, while communities with 1.0-1.2 ppr had a rate of 113.0 per 100,000 (95% CI: 95.4-130.5). An increase of 0.1 ppr in a community was associated with a 40% increase in risk of >/=2 TB cases occurring, while an increase of $10,000 in community household income was associated with 0.25 the risk, and being an isolated community increased risk by 2.5 times. CONCLUSIONS: This study shows a significant association between housing density, isolation, income levels, and TB. Overcrowded housing has the potential to increase exposure of susceptible individuals to infectious TB cases, and isolation from health services may increase the likelihood of TB.

Canada↗

Factors associated with willingness to try different pain treatments for pain after a spinal cord injury.

OBJECTIVE: To develop and establish the psychometric properties of a pain treatment willingness scale and identify factors associated with willingness to try specific pain treatments for spinal cord injury (SCI)-related pain. DESIGN: As part of a larger study, a questionnaire was designed to assess willingness to use various pain medications and other types of pain treatments. This questionnaire, which included measures of pain severity, pain interference, mood, hope, and current use of pain treatments, was completed by persons with SCI recruited through the mail or in person. SUBJECTS: One hundred fifteen persons completed the questionnaire (35% response rate). Seventy-two percent of the participants were men, mean age was 49.1 years, and average time elapsed since injury was 8 years. RESULTS: Factor analysis indicated two factors-willingness to use opioids and willingness to use nonpharmacological treatment (i.e., physical therapy, relaxation methods and stress management, and alternative medicine). Internal consistency and convergent and divergent validity were established. Persons experiencing SCI-related pain were more willing to use pain treatments than those without current pain, and those who were currently using opioids reported greater willingness to use that treatment. Persons who reported SCI-related pain were more willing to use nonpharmacological treatments than opioid medications. Finally, participants demonstrated different degrees of willingness to use an opioid medication based on its name (i.e., "narcotic," "codeine," "morphine," "methadone"). CONCLUSIONS: Willingness to use a specific pain treatment may be a key factor mediating the behavior of using that specific treatment. Assessment of patient attitudes toward various treatments options, particularly regarding opioid medications, is warranted to optimize treatment adherence. Once the factors that determine these attitudes are identified, interventions to increase willingness to use nonpharmacological or opioid treatments can be designed and evaluated.

Adaptation, Psychological↗

Changing pressure-redistributing mattress stocks: costs and outcomes.

There remains considerable confusion regarding the selection of appropriate pressure-redistributing support surfaces, although it is accepted that use of low-pressure foam mattresses is likely to reduce the incidence of pressure ulcers compared with standard hospital mattresses. In this study, a 650- hospital replaced its mattress stock with low-pressure foam mattresses with over pounds sterling 100 000 cost savings in the first year after implementation. Incidence and prevalence data were recorded but given the challenges of interpreting apparent trends in the data (due to the lack of robust data collection methodologies and no case-mix adjustment) these data were not included.

Beds↗