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Biomedical subjects

Michael E Kelley

Publications and source records attributed to Michael E Kelley.

11 recordsLinked to original sources

Some effects of stimulant medication on response allocation: a double-blind analysis.

Children who are diagnosed with attention deficit hyperactivity disorder (or who engage in behavior consistent with such a diagnosis) are often prescribed stimulant medications for hyperactive or inattentive behaviors. However, the mechanisms by which stimulant medications affect individuals' behavior are rarely evaluated. The purpose of the current study was to evaluate the effects of stimulant medication on response allocation when antecedents and consequences were held constant and equated. Results indicated that the presence of an amphetamine medication (Adderall) influenced response allocation across two concurrently available responses while all other stimulus conditions were held constant.

Amphetamines↗

Mecamylamine (Targacept).

Targacept Inc, under license from the University of South Florida, is developing a low-dose, liquid gel capsule formulation of the nicotinic acetylcholine antagonist mecamylamine, as a potential treatment for various neuropsychiatric disorders.

Adolescent↗

Increasing variety of foods consumed by blending nonpreferred foods into preferred foods.

UNLABELLED: A treatment with differential or noncontingent reinforcement and nonremoval of the spoon increased the acceptance of one or two of 16 foods for 2 participants with severe food refusal. These differential levels of acceptance were demonstrated empirically in an ABAB design in which A was the presentation of the accepted (preferred) foods and B was the presentation of foods the participants refused (nonpreferred foods). Subsequently, we implemented a blending treatment that consisted of mixing (blending) nonpreferred foods into preferred foods in various ratios (e.g., 10% nonpreferred/90% preferred, 20% nonpreferred/80% preferred). We then presented nonpreferred foods that had been exposed to blending to determine if consumption of nonpreferred foods would increase following the blending treatment. We also conducted periodic reversals in which we presented nonpreferred foods that had not been exposed to the blending treatment. Following initial implementation of the blending treatment, consumption was high for nonpreferred foods that had been blended and low for nonpreferred foods that had not been blended. Consumption increased for all foods (i.e., foods that had been exposed to blending and foods that had not been exposed to blending) after seven or eight foods had been exposed to the blending treatment. Thus, the variety of foods consumed by the participants increased from one or two to 16. These results are discussed in terms of stimulus fading, conditioned food preferences, and escape extinction. DESCRIPTORS: conditioned food preferences, food refusal, negative reinforcement, stimulus fading

Child, Preschool↗

Collateral effects of response blocking during the treatment of stereotypic behavior.

The collateral effects of response blocking were evaluated while treating stereotypic behavior in a woman diagnosed with autism. Blocking stereotypic behavior (head and tooth capping) was associated with decreases in leisure-item interaction and increases in another stereotypic response (hand wringing). Results suggested that the reduction in item interaction was due to adventitious punishment. Prompts to access an alternative source of reinforcement attenuated the side effects somewhat, but results suggested that the undesirable effects of response blocking may be fairly durable.

Adolescent↗

Visual aids and structured criteria for improving visual inspection and interpretation of single-case designs.

Because behavior analysis is a data-driven process, a critical skill for behavior analysts is accurate visual inspection and interpretation of single-case data. Study 1 was a basic study in which we increased the accuracy of visual inspection methods for A-B designs through two refinements of the split-middle (SM) method called the dual-criteria (DC) and conservative dual-criteria (CDC) methods. The accuracy of these visual inspection methods was compared with one another and with two statistical methods (Allison & Gorman, 1993; Gottman, 1981) using a computer-simulated Monte Carlo study. Results indicated that the DC and CDC methods controlled Type I error rates much better than the SM method and had considerably higher power (to detect real treatment effects) than the two statistical methods. In Study 2, brief verbal and written instructions with modeling were used to train 5 staff members to use the DC method, and in Study 3, these training methods were incorporated into a slide presentation and were used to rapidly (i.e., 15 min) train a large group of individuals (N = 87). Interpretation accuracy increased from a baseline mean of 55% to a treatment mean of 94% in Study 2 and from a baseline mean of 71% to a treatment mean of 95% in Study 3. Thus, Study 1 answered basic questions about the accuracy of several methods of interpreting A-B designs; Study 2 showed how that information could be used to increase the accuracy of human visual inspectors; and Study 3 showed how the training procedures from Study 2 could be modified into a format that would facilitate rapid training of large groups of individuals to interpret single-case designs.

Audiovisual Aids↗

Training parents to implement pediatric feeding protocols.

Four different multicomponent training packages were evaluated to increase the treatment integrity of parents implementing pediatric feeding protocols. In Study 1 we exposed 3 parents to a training package that consisted of written protocols (baseline), verbal instructions, therapist modeling, and rehearsal training. Results suggested that the package was successful in increasing treatment integrity of the feeding protocols to high levels. Study 2 investigated three different parent-training packages comprised of components used in Study 1. Two parents were exposed to written protocols, verbal instructions, and modeling; 2 parents were exposed to written protocols, verbal instructions, and rehearsal; and 2 parents were exposed to written protocols and verbal instructions. Results of Study 2 showed that each parent-training package produced very high treatment integrity. Follow-up data in the clinic and home for 5 participants suggested that the results were durable for up to 3 months. These results demonstrate a first step in the transfer and application of research findings into routine clinical practice because we evaluated several methods for training parents to implement behavioral feeding protocols, and we demonstrated that these methods resulted in high levels of treatment integrity in a controlled clinical setting.

Behavior Therapy↗

Reinforcement magnitude and responding during treatment with differential reinforcement.

Basic findings indicate that the amount or magnitude of reinforcement can influence free-operant responding prior to and during extinction. In this study, the relation between reinforcement magnitude and adaptive behavior was evaluated with 3 children as part of treatment with differential reinforcement. In the first experiment, a communicative response was shaped and maintained by the same reinforcer that was found to maintain problem behavior. Two reinforcement magnitudes (20-s or 60-s access to toys or escape from demands) were compared and found to be associated with similar levels of resistance to extinction. The relation between reinforcement magnitude and response maintenance was further evaluated in the second experiment by exposing the communicative response to 20-s or 300-s access to toys or escape. Results for 2 participants suggested that this factor may alter the duration of postreinforcement pauses.

Adult↗

Further evaluation of the role of protective equipment in the functional analysis of self-injurious behavior.

Using a procedure similar to the one described by Le and Smith (in press), we evaluated the effects of protective equipment during a functional analysis for 2 individuals who engaged in severe self-injurious behavior (SIB). Results of our analyses revealed that the use of protective equipment during functional analyses of SIB suppressed levels of responding such that a behavioral function could not be identified.

Adult↗