A technique for performing PCR on extremely large DNA molecules offers researchers the ability to generate accurate multi-marker haplotypes for large numbers of patients--even with loci arrayed across entire human chromosomes.

Chromosome Mapping↗

PubMed2006

Coke and chips--a winning combination?

An aptamer-based electronic sensor for the detection of cocaine demonstrates the capabilities of a sensitive and generalizable new platform for small-molecule recognition.

Aptamers, Nucleotide↗

PubMed2006

A new twist for DNA.

A computer-aided design strategy allows scientists to 'staple' DNA molecules into a wide variety of two-dimensional shapes, generating precisely arranged scaffolds that could serve as promising platforms for nanoscale research applications.

Computer-Aided Design↗

PubMed2006

My enemy's enemy is my friend.

Bacteriophages form the foundation for a rapid and sensitive bacterial detection assay, capable of revealing the presence of a few dozen cells in a milliliter sample.

Bacterial Infections↗

PubMed2006

Tracking the wily transcription factor.

A 'paired-end ditag' (PET) strategy for pinpointing protein binding sites can reveal a wealth of information about transcription factors and other DNA-binding proteins.

Binding Sites↗

PubMed2006

Exploring how the organelles are organized.

New work from several laboratories describes ongoing efforts to explore a new proteomic frontier--mapping and indexing the protein content of the cellular organelles.

Animals↗

PubMed2006

More than just 'doing the math'.

Two new articles show how computational tools continue to move beyond mere sequence-based bioinformatic analysis into more advanced arenas of prediction, deduction and network building.

Animals↗

PubMed2006

Getting a DNA to do an RNA's job.

The successful in vitro evolution of a DNA enzyme based on a ribozyme could offer insights into early evolutionary events and provide guidelines for designing hardier catalytic oligonucleotides.

DNA↗

PubMed2006

Sorting out the best targets.

Explore the source record for details and available documents.

Escherichia coli↗