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Michael L Washington

Publications and source records attributed to Michael L Washington.

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Interdisciplinary epidemiologic and economic research needed to support a universal childhood influenza vaccination policy.

Recent research indicates that influenza vaccination of children may decrease the influenza disease burden in adults to a greater extent than targeting vaccination to populations at high risk of serious disease. Possible new policies reflecting these results would add groups most likely to transmit disease to existing vaccination recommendations. Interdisciplinary research combining epidemiology with economics is needed to answer critical questions about the desirability and feasibility of potential new policies, such as what additional resources medical providers might need to expand vaccination to larger groups or what opportunity costs parents might incur in vaccinating their children annually. In this paper, the authors provide background for some of the changes in influenza vaccination rates and disease and discuss existing information gaps and research methods capable of closing these gaps. They provide several examples of interdisciplinary studies that have incorporated both economics and epidemiology or health policy issues. These studies are representative of a variety of stakeholder perspectives needed to determine whether community-based, universal childhood vaccination policies would be more efficacious and cost-effective than strategies targeted toward persons at high risk of disease complications.

Child↗

A personnel time-motion study of intranasal influenza vaccination in healthy children.

Vaccinating millions of Americans depends, in part, on short vaccination times. During two intranasal influenza vaccine trials, times for six vaccination steps were recorded for 497 children. The total of mean times for the steps was 115 s, almost half spent explaining the vaccine and intranasal delivery. Intranasal influenza vaccination time showed little variation by patient age, was comparable to reported intramuscular vaccination times, and was a small fraction of the visit time. Total family visit time decreased by 64 s if the youngest child was receiving a second dose. Alternative delivery systems (e.g., group visits) are needed to take advantage of short vaccination times.

Administration, Intranasal↗

Time spent by primary care practices on pediatric influenza vaccination visits: implications for universal influenza vaccination.

OBJECTIVE: To measure the time currently spent by primary care practice personnel, and the examination room occupancy time for childhood influenza vaccination visits, to assess the practicality of annual influenza vaccination of all preschool children. SETTING: Seven primary care practices serving one fourth of the children living in Rochester, NY. PATIENTS: Ninety-two children seen for influenza vaccination visits in the 2000-2001 vaccination season. METHODS: Using a standardized protocol, practice staff measured the time spent on check-in, nurse or physician examination, and the actual influenza vaccination process. Waiting and "hands-on" times were determined, as well as total visit and room occupancy times. Nonparametric tests and multivariable models were used to analyze the time spent for components of the visits and to compare time spent by different age groups and practice types (suburban or urban). RESULTS: The median duration of the influenza vaccination visit was 14 minutes (25th to 75th percentiles range, 9-25 minutes) across the 7 practices, with visits to urban practices being longer (22 minutes) than visits to suburban practices (9 minutes). Eighty percent of patient time involved waiting, primarily in examination rooms. The major components of influenza vaccination visits included waiting room time (4 minutes in suburban practices vs 8 minutes in urban practices; P<.01), and time in the examination room (5 minutes vs 14 minutes, respectively; P<.001), during which only 1 to 2 minutes (for both suburban and urban practices) were for hands-on vaccinations. Only 5% of visits were examined by a physician or nurse practitioner. Visit times did not vary by age. CONCLUSIONS: Although the personnel time for influenza vaccination visits was short, there was substantial patient waiting and long occupancy of examination rooms. If universal influenza vaccination is to be efficiently managed in primary care practices, it may be necessary to implement "vaccination clinics" or sessions in which large numbers of children are scheduled for influenza vaccinations at times when adequate rooms and dedicated nursing staff are available.

Child↗

Parental knowledge, attitudes, and practices associated with not receiving hepatitis A vaccine in a demonstration project in Butte County, California.

OBJECTIVE: To determine hepatitis A vaccination coverage and factors associated with not receiving hepatitis A vaccine among children. METHODS: A random cluster sample survey was conducted of parents of children who attended kindergarten in Butte County, California, in 2000. Because of a history of recurrent epidemics, an aggressive hepatitis A vaccination program was ongoing during the time this study was conducted. Receipt of 1 or 2 doses of hepatitis A vaccine was studied. RESULTS: Of 896 surveys sent, 648 (72%) were completed. The vaccination coverage for at least 1 dose of hepatitis A vaccine was 398 (62%) and for 2 doses was 272 (42%). Factors associated with not receiving the vaccine included lack of provider recommendation (vs having recommendation; odds ratio [OR]: 7.8; 95% confidence interval [CI]: 4.9-12.2), not having heard of the vaccine (OR: 2.4; 95% CI: 1.2-4.9), and parent's not perceiving child is likely to get hepatitis A (vs perceiving child might get disease; OR: 2.1; CI: 1.6-2.9). CONCLUSIONS: Vaccination coverage among kindergartners did not reach high levels (ie, >90%), despite aggressive vaccination efforts in this community. Lack of provider recommendation and lack of parental awareness of hepatitis A vaccine were the 2 most significant factors associated with failure to receive vaccine. These findings will facilitate the development of vaccination strategies for communities in which hepatitis A vaccination is recommended.

Adult↗

Frequency and causes of vaccine wastage.

UNLABELLED: Assessing the frequency of vaccine wastage and the relative magnitude of its various causes may help to target efforts to reduce these losses and to husband funds for increasingly expensive vaccines. METHODS: As a preliminary overview of wastage in the United States, 64 public-sector state and local health department immunization programs were polled in 1998 and 1999 for wastage recording practices. Actual wastage data were collected from a non-random subset of five states. Data on returns of wasted vaccine to manufacturers were analyzed from routine national biologics surveillance and from an ad-hoc survey. Excise tax credit requests for such returns between 1994 and 1999 were reviewed. RESULTS: Rates of wastage among the five states ranged from about 1 to 5% in 1998, with an overall rate of 2.6% among 57 immunization programs in 1999. Categories of wastage used by the health departments varied widely, with overlapping classifications. The major causes appeared to be refrigeration (cold chain) lapses, followed by expiration. Overall rates of vaccine returns varied up to 8% by manufacturer, and from 1 to 50% by vaccine type, with higher return rates generally found for lesser-used vaccines. CONCLUSIONS: If these wastage estimates of 1-5% applied nationally, in 1998 there would have been approximately US dollars 6-31 million worth of unused vaccine in the public sector alone. The two most common forms of wastage reveal the potential value of developing vaccines with improved heat stability and longer shelf lives. We propose six main classifications of vaccine wastage for use in routine monitoring and reporting.

Humans↗

Maxi-Vac: planning mass smallpox vaccination clinics.

To help emergency response planners prepare for conducting mass smallpox vaccination clinics, the Centers for Disease Control and Prevention researchers developed the Maxi-Vac software (available free from http://www.bt.cdc.gov/agent/smallpox/vaccination/maxi-vac/index.asp); it assists in designing a mass vaccination clinic with up to 9 separate stations. Users select clinic characteristics that best represent their intended setup, and the software displays the optimal placement of staff to vaccinate the maximum number of people possible. For example, for a clinic that will have 3 physicians, 30 nurses, and 10 other staff members available per 12-hour shift, Maxi-Vac shows how these staff members can best be deployed, and it projects the maximum number of persons who can be vaccinated at 8,245 per 24-hour period. Users can alter the number of available staff, which will probably be the greatest limiting factor, to determine the impact on the number of persons vaccinated per 24-hour period.

Bioterrorism↗

Do patterns of knowledge and attitudes exist among unvaccinated seniors?

OBJECTIVE: To examine patterns of knowledge and attitudes among adults aged > 65 years unvaccinated for influenza. METHODS: Surveyed Medicare beneficiaries in 5 areas; clustered unvaccinated seniors by their immunization related knowledge and attitudes. RESULTS: Identified 4 clusters: Potentials (45%) would receive influenza vaccine to prevent disease; Fearful Uninformeds (9%) were unsure if influenza vaccine causes illness; Doubters (27%) were unsure if vaccine is efficacious; Misinformeds (19%) believed influenza vaccine causes illness. More Potentials (75%) and Misinformeds (70%) ever received influenza vaccine than did Fearful Uninformeds (18%) and Doubters (29%). CONCLUSION: Findings suggest that cluster analyses may be useful in identifying groups for targeted health messages.

Aged↗