Biomedical subjects

Michael Lindenbaum

Publications and source records attributed to Michael Lindenbaum.

4 recordsLinked to original sources

PubMed2007

Surface dependent representations for illumination insensitive image comparison.

We consider the problem of matching images to tell whether they come from the same scene viewed under different lighting conditions. We show that the surface characteristics determine the type of image comparison method that should be used. Previous work has shown the effectiveness of comparing the image gradient direction for surfaces with material properties that change rapidly in one direction. We show analytically that two other widely used methods, normalized correlation of small windows and comparison of multiscale oriented filters, essentially compute the same thing. Then, we show that for surfaces whose properties change more slowly, comparison of the output of whitening filters is most effective. This suggests that a combination of these strategies should be employed to compare general objects. We discuss indications that Gabor jets use such a mixed strategy effectively, and we propose a new mixed strategy. We validate our results on synthetic and real images.

Algorithms↗

PubMed2006

On the distribution of saliency.

Detecting salient structures is a basic task in perceptual organization. Saliency algorithms typically mark edge-points with some saliency measure, which grows with the length and smoothness of the curve on which these edge-points lie. Here, we propose a modified saliency estimation mechanism that is based on probabilistically specified grouping cues and on curve length distributions. In this framework, the Shashua and Ullman saliency mechanism may be interpreted as a process for detecting the curve with maximal expected length. Generalized types of saliency naturally follow. We propose several specific generalizations (e.g., gray-level-based saliency) and rigorously derive the limitations on generalized saliency types. We then carry out a probabilistic analysis of expected length saliencies. Using ergodicity and asymptotic analysis, we derive the saliency distributions associated with the main curves and with the rest of the image. We then extend this analysis to finite-length curves. Using the derived distributions, we derive the optimal threshold on the saliency for discriminating between figure and background and bound the saliency-based figure-from-ground performance.

Algorithms↗

PubMed2006

Attention-based dynamic visual search using inner-scene similarity: algorithms and bounds.

A visual search is required when applying a recognition process on a scene containing multiple objects. In such cases, we would like to avoid an exhaustive sequential search. This work proposes a dynamic visual search framework based mainly on innerscene similarity. Given a number of candidates (e.g., subimages), we hypothesize is that more visually similar candidates are more likely to have the same identity. We use this assumption for determining the order of attention. Both deterministic and stochastic approaches, relying on this hypothesis, are considered. Under the deterministic approach, we suggest a measure similar to Kolmogorov's epsilon-covering that quantifies the difficulty of a search task. We show that this measure bounds the performance of all search algorithms and suggest a simple algorithm that meets this bound. Under the stochastic approach, we model the identity of the candidates as a set of correlated random variables and derive a search procedure based on linear estimation. Several experiments are presented in which the statistical characteristics, search algorithm, and bound are evaluated and verified.

Algorithms↗

PubMed2004

A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy.

Mammalian artificial chromosomes (MACs) provide a means to introduce large payloads of genetic information into the cell in an autonomously replicating, non-integrating format. Unique among MACs, the mammalian satellite DNA-based Artificial Chromosome Expression (ACE) can be reproducibly generated de novo in cell lines of different species and readily purified from the host cells' chromosomes. Purified mammalian ACEs can then be re-introduced into a variety of recipient cell lines where they have been stably maintained for extended periods in the absence of selective pressure. In order to extend the utility of ACEs, we have established the ACE System, a versatile and flexible platform for the reliable engineering of ACEs. The ACE System includes a Platform ACE, containing >50 recombination acceptor sites, that can carry single or multiple copies of genes of interest using specially designed targeting vectors (ATV) and a site-specific integrase (ACE Integrase). Using this approach, specific loading of one or two gene targets has been achieved in LMTK(-) and CHO cells. The use of the ACE System for biological engineering of eukaryotic cells, including mammalian cells, with applications in biopharmaceutical production, transgenesis and gene-based cell therapy is discussed.

Animals↗