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Michael Ludwig

Publications and source records attributed to Michael Ludwig.

58 records · Page 4Linked to original sources
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Malformation rate in fetuses and children conceived after ICSI: results of a prospective cohort study.

There is an ongoing discussion regarding conflicting data on malformation rate in children born after intracytoplasmic sperm injection (ICSI). A prospective, multicentric, control cohort study was done in Germany. Fifty-nine centres prospectively recruited pregnancies before the 16th week of gestation, which were included in the study if they were ongoing beyond this time. Children were examined according to a standardized procedure. A control cohort of children conceived spontaneously was taken from a prospective birth registry (Mainzer Modell), where children were examined according to the exact same criteria as the ICSI cohort. Major malformation rate was calculated, based on data of all liveborn and stillborn children, as well as on all spontaneous and induced abortions, beginning with the 16th week of gestation. In the ICSI cohort, 8.6% of infants (291/3372), and in the control cohort 6.9% of infants (2140/30940), had a major malformation. This resulted in a crude relative risk (RR) of 1.25 (95% confidence interval 1.11-1.40). There was no influence of sperm origin on major malformation rate in children born after ICSI. There is an increased risk for a child born after ICSI to have a major malformation compared with a child that has been spontaneously conceived. Based on knowledge of the early developmental steps following ICSI, as well as on data of conventional IVF in general, it is assumed that this increased risk is due to parental factors causing the infertility, which has led to ICSI in the first place.

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PubMedDate not supplied

Follow-up of children born after assisted reproductive technologies.

The course of pregnancies and the health of children born after assisted reproductive technologies are two of the most important outcome parameters of the quality of the techniques. There is an ongoing discussion as to whether these parameters may show poorer results as compared with spontaneous conception. Recent studies have shown increased risks for the pregnancy course following conventional IVF (e.g. premature birth, low birthweight), and a higher rate of major malformations after conventional IVF as well as after intracytoplasmic sperm injection. Molecular biological studies may support the idea that these risks are not related to the techniques used, but to parental background factors. Data from surrogate motherhood also demonstrate that here the risk is lower as compared with pregnancies from IVF mothers, who carry their own child to birth. Therefore, there are more infertility related problems than those related to technique. Finally, however, a risk related to the technique itself cannot be excluded completely by currently available data.

Congenital Abnormalities↗