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Biomedical subjects

Michael P Wines

Publications and source records attributed to Michael P Wines.

2 recordsLinked to original sources

A new minimally invasive technique for treating radiation cystitis: the argon-beam coagulator.

OBJECTIVE: To assess the effectiveness of the argon-beam coagulator used endoscopically for treating radiation cystitis, as radiotherapy is commonly used for treating pelvic tumours of urological origin, but intractable bleeding related to radiation cystitis remains a serious complication and requires a difficult long-term follow-up, for which cystoscopic methods of management have traditionally had limited success. PATIENTS AND METHODS: We assessed seven patients with radiation cystitis; they were treated with argon-beam coagulation after a cystoscopic evaluation. RESULTS: With a mean follow-up of 15 months, one treatment was used in six patients, with a second treatment required in one. CONCLUSION: The argon-beam coagulator appears to be a safe, well tolerated and minimally invasive treatment in patients with radiation cystitis.

Argon↗

Thalidomide in dermatology.

Thalidomide is an effective agent to treat over 25 seemingly unrelated dermatological conditions that have an inflammatory or autoimmune basis. The main side-effects of teratogenesis and peripheral neuropathy limit its use. Currently, in Australia no assurance is given as to the quality, safety and efficacy of thalidomide. The use of thalidomide for toxic epidermal necrolysis can lead to an increase in mortality, and its use as a prophylactic agent for the prevention of chronic graft-versus-host disease following bone marrow transplantation has raised more speculations as to the safety of this notorious drug. A review of the therapeutic indications for thalidomide in dermatology as well as the mechanisms of action and side-effects of this drug are presented. The current suggested guidelines for its use in clinical practice in Australia are discussed.

Dermatologic Agents↗