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Biomedical subjects

Michael S Gelfand

Publications and source records attributed to Michael S Gelfand.

6 recordsLinked to original sources
PubMed2006

Pathological fracture in acute osteomyelitis of long bones secondary to community-acquired methicillin-resistant Staphylococcus aureus: two cases and review of the literature.

Pathologic fracture is a rare complication of acute bacterial osteomyelitis in adults. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has been increasingly reported in skin and soft tissue and systemic infections in children and adults, including many cases of osteomyelitis. We recently treated two adult patients with acute osteomyelitis of long bones secondary to CA-MRSA complicated by a pathologic fracture. In both patients, the primary source of dissemination to the bone was a skin and soft tissue infection. We speculate that virulence factors specific for CA-MRSA currently circulating in the United States may predispose to a complicated course of acute osteomyelitis.

Adult↗
PubMed2004

Vancomycin therapy and the progression of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis.

Vancomycin therapy is the standard treatment for methicillin-resistant Staphylococcus aureus (MRSA), the most common cause of vertebral osteomyelitis, an increasingly frequent complication of nosocomial bacteremia. We report five recent cases suggesting that, while giving the appearance of success by conventional clinical and laboratory criteria (eg, resolution of fever and leukocytosis), vancomycin monotherapy may in fact be insufficient to prevent or reverse the progression of hematogenous MSRA vertebral osteomyelitis. A review of the literature and possible therapeutic alternatives are also discussed.

Aged↗
PubMed2004

Evolving infectious aortitis caused by Streptococcus pneumoniae.

Infections of major vessels leading to mycotic aneurysms can be a diagnostic dilemma for clinicians, and can be accompanied by a high mortality rate. Successful treatment of this condition often requires a high index of suspicion and prompt medical and surgical attention. The authors report two cases of infectious aortitis caused by pneumococcus that evolved during hospitalization, and discuss diagnostic difficulties that accompany this entity.

Aged↗
PubMed2003

West Nile virus infection. What you need to know about this emerging threat.

The most important aspects to remember about West Nile virus infection are summed up in the following points: West Nile virus is transmitted by bites from infected Culex species mosquitoes. Most infections do not result in serious illness. Encephalitis and serious morbidity and mortality are more likely to occur in elderly persons than in any other age-group. No effective antiviral treatment is available. Avoiding contact with mosquitoes is the key preventive measure.

Adult↗