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Biomedical subjects

Michael Schenker

Publications and source records attributed to Michael Schenker.

4 recordsLinked to original sources

Precision grip function after free toe transfer in children with hypoplastic digits.

Although toe-to-hand transfer has a defined role in the management of congenital hand deformities, it remains unclear how well children integrate the transferred digits into physiological grasping. We analysed fingertip forces in the precision grip of 13 patients when lifting a test object more than three years after free toe transfer for absent or hypoplastic digits. Clinically, most patients showed normal sensibility of transferred digits, but active motion and pinch strength were limited as compared to the normal hand. For the control of fingertip forces, two key features of the normal two-digit opposition grip were seen in all operated hands: adaptation of grip force to object weight and parallel coordination of lift and grip forces. These physiological grasping strategies developed independently of the patients' age at the time of operation, which ranged from one to 13 years. In four patients, we observed increased tangential load forces with the operated hand due to misalignments in the application of fingertips on the grasp surfaces. Such forces lead to increased grip force requirements on both fingers that may overload transferred digits with limited motor function. The need for optimal alignment of the grip axis during toe-transfer surgery is emphasised.

Adaptation, Physiological↗

Impact of laboratory testing on DRG coding and reimbursement--results of a data base research.

We filed an Australian data base with about 7 million well-documented clinical cases for comorbidities, which can be proven, supported or excluded by laboratory testing and which have an impact on DRG reimbursement. The result was a list of 123 DRGs being shifted to a higher severity level by documenting one out of 157 complications. For better visualization of the more than 4,000 combinations, we developed a computer program, which allows the laboratory to develop its own diagnostic pathways for these complications in a simple Excel format.

Australia↗

[Diagnosis of nosocomial pneumonia: conventional and new indicators].

Nosocomial pneumonia is difficult to diagnose. Clinical criteria, saliva and tracheal specimen cultures can be sensitive to bacterial pathogeny, they are however nonspecific in patients with assisted mechanical ventilation; on the other hand, blood and pleural liquid cultures have very poor sensitivity. Fever and leukocytosis are not constant signs and are not compulsory for diagnosing nosocomial pneumonia (NP). Interleukine 1 (IL-1) is a proinflammatory cytokine produced by macrophages, but research studies failed to indicate some connection to the incidence or clinical outcome in nosocomial pneumonia. Tumoral necrosis factor (TNF) is considered one of the most important mediators of endotoxin induced effects: studies on acute inflammatory conditions such as severe sepsis indicated a link between the homozygosity of TNFb2 and the mortality or the incidence of nosocomial pneumonia in trauma patients. Procalcitonin (PCT) is a parameter different from other markers currently available to evaluate inflammatory response. PCT is induced by bacterial inflammation selectively and also appears in sepsis and in MODS. PCT values higher than 0.5 ng/mL always indicate acute infection or septic inflammation.

Biomarkers↗

[Comparison between continuous epidural instillation of ropivacaine and bupivacaine in patients with lung cancer].

We compared the efficiency of continuous epidural analgesia with ropivacaine and bupivacaine in patients with lung carcinoma stages IIIB and IV. We studied 25 patients aged 48-70 years, divided in two groups A (13 patients) and B (12 patients). Group A received continuous epidural infusion with ropivacaine 0.2%, 6 ml/h and group B received continuous epidural infusion with bupivacaine 0.2%, 6 ml/h. Pain level, neuromuscular block intensity and PONV incidence were similar in both groups during the first 72 hours. The ropivacaine group needed more nonopioid analgesic (Dinastat).

Aged↗