Degenerative disc disease: genotyping, MR imaging and phenotyping.
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Genotype↗
Biomedical subjects
Michael T Modic
Publications and source records attributed to Michael T Modic.
Total body screening: predicting actionable findings.
RATIONALE AND OBJECTIVES: Total body screening, despite its popularity, has not been evaluated in clinical trials. Even the appropriate target for screening has not been addressed. In this study, we determined the variables from a subject's demographic and medical and family history that are predictive of actionable findings on total body screening. MATERIALS AND METHODS: Over a 3-year period, 982 self-referred subjects underwent total body screening with multislice computed tomography and completed a demographic and medical history questionnaire. The study sample was divided into training and testing samples. Univariate and multiple-variable statistical methods were used on the training sample to derive models that predict actionable lung findings, actionable heart findings, actionable abdomen/pelvis findings, and any actionable findings on total body screening. The training models were then applied and evaluated on the test sample. RESULTS: A subject's age at the time of screening was the single most important predictor and often the only significant predictor of actionable findings. Among subjects younger than 40 years of age, 22.5% had actionable findings; this number nearly doubled, to 43.5%, for subjects between 40 and 49, and increased to 80% for subjects 80 years and older. Overall, every increase of 10 years in age brings an increase of 1.6 in the likelihood of an actionable finding. CONCLUSIONS: Total body screening targeted at older subjects has the highest yield of actionable findings. The efficacy and cost-effectiveness of total body screening for older subjects is unknown and needs further assessment.
Computer Simulation↗
Coronary artery imaging with multidetector computed tomography: a call for an evidence-based, multidisciplinary approach.
Modern multidetector computed tomography systems are capable of a comprehensive assessment of the cardiovascular system, including noninvasive assessment of coronary anatomy. Multidetector computed tomography is expected to advance the role of noninvasive imaging for coronary artery disease, but clinical experience is still limited. Clinical guidelines are necessary to standardize scanner technology and appropriate clinical applications for coronary computed tomographic angiography. Further evaluation of this evolving technology will benefit from cooperation between different medical specialties, imaging scientists, and manufacturers of multidetector computed tomography systems, supporting multidisciplinary teams focused on the diagnosis and treatment of early and advanced stages of coronary artery disease. This cooperation will provide the necessary education, training, and guidelines for physicians and technologists assuring standard of care for their patients.
Coronary Angiography↗
Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome.
PURPOSE: To prospectively determine in patients with acute low back pain (LBP) or radiculopathy, the magnetic resonance (MR) imaging findings, prognostic role of these findings, and effect of diagnostic information on outcome. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. This study was HIPAA compliant. A total of 246 patients with acute-onset LBP or radiculopathy were randomized to either the early information arm of the study, with MR results provided within 48 hours, or the second arm of the study, where both patients and physicians were blinded to MR results, unless this information was critical to patient care. Patients underwent 6 weeks of conservative care. Roland function scoring, visual pain analog, Short Form 36 health status survey, self-efficacy scoring, and a fear avoidance questionnaire were completed at presentation; at 2-, 4-, 6-, and 8-week follow-up; and at 6-, 12-, and 24-month follow-up. A second MR imaging examination was performed at 6-week follow-up. Multivariate logistic regression analysis was used to determine which imaging and nonimaging variables can be used to predict improvement in Roland function and patient satisfaction. The chi(2) test and repeated-measures analysis of variance were used to compare outcome of blinded and unblinded patients. RESULTS: Herniation was identified in 60% (n = 147) of patients at the initial examination. The prevalence of herniations in patients with LBP (57%) (n = 85) and those with radiculopathy (65%) (n = 62) were similar (P = .217), although patients with radiculopathy were more likely to have stenosis and nerve root compression (P < .006). There was no relationship between herniation type, size, and behavior over time with outcome. An improvement of 50% or more in Roland function score at 6-week follow-up occurred 2.7 times as often among patients with a herniation at baseline (P = .003). Improvement at 6-week follow-up was similar in unblinded (60%) (n = 55) and blinded (67%) (n = 57) patients (P = .397). Self-efficacy, fear avoidance beliefs, and the Short Form 36 subscales were similar for blinded and unblinded patients. CONCLUSION: In typical patients with LBP or radiculopathy, MR imaging does not appear to have measurable value in terms of planning conservative care. Patient knowledge of imaging findings does not alter outcome and is associated with a lesser sense of well-being.
Acute Disease↗
Screening with multisection CT: unmasking the benefit.
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Humans↗
Whole-body CT screening for cancer and coronary disease: does it pass the test?
Even though whole-body CT scanning is being marketed directly to patients and they are starting to demand it, does it meet the standards of a good screening test for cancer and coronary artery disease? This article is a step-by-step, disease-specific discussion of the characteristics of a good screening test, and whether whole-body CT scanning meets these standards.
Colorectal Neoplasms↗
Calcium scoring: criteria for evaluating its effectiveness.
Engineering advances in CT have produced multi-slice instruments that can scan large areas of the body in short periods of time, and such instruments now permit high resolution examination of entire anatomic regions (eg, the chest) in a single breath hold. Alternatively, these instruments can quickly scan small areas (such as the heart) with very high resolution in a very short period of time (eg, diastole). Using such CT scanners, there is no question that coronary artery calcium can be detected in small quantities and scored accurately. However, coronary calcium screening, like all screening procedures, poses a significant dilemma: early detection in a few is almost always accompanied by negative consequences for others (eg, false positives causing anxiety and unnecessary work-up, and false negatives causing delayed treatment and false reassurance). How do we balance the benefits to a few against the negative effects to others? That is the subject of this paper. A starting point for resolving the screening dilemma is to count the number of patients needed to be screened to benefit one patient (the NNS), and conversely, to determine the number of patients screened before harming one patient (NSH). Another approach is to apply published criteria suggested for the evaluation of a screening program targeted at early disease detection. In this review article, we propose 10 criteria for evaluating the effectiveness of a screening test designed to detect a risk factor for disease (ie, calcium scoring as a risk factor for coronary artery disease). We discuss how these criteria can be used to estimate NNS and NSH. Although this work focuses on coronary calcification screening, reference is made as well to other areas, such as lung and colon cancer screening.
Calcinosis↗