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Biomedical subjects

Michael Wayne Matthews

Publications and source records attributed to Michael Wayne Matthews.

2 recordsLinked to original sources

Magnetically adjustable intraocular lens.

PURPOSE: To provide a noninvasive, magnetic adjustment mechanism to the repeatedly and reversibly adjustable, variable-focus intraocular lens (IOL). SETTING: University of Missouri-Rolla, Rolla, and Eggleston Adjustable Lens, St. Louis, Missouri, USA. METHODS: Mechanically adjustable IOLs have been fabricated and tested. Samarium and cobalt rare-earth magnets have been incorporated into the poly(methyl methacrylate) (PMMA) optic of these adjustable lenses. The stability of samarium and cobalt in the PMMA matrix was examined with leaching studies. Operational force testing of the magnetic optics with emphasis on the rotational forces of adjustment was done. RESULTS: Prototype optics incorporating rare-earth magnetic inserts were consistently produced. After 32 days in solution, samarium and cobalt concentration reached a maximum of 5 ppm. Operational force measurements indicate that successful adjustments of this lens can be made using external magnetic fields with rotational torques in excess of 0.6 ounce inch produced. Actual lenses were remotely adjusted using magnetic fields. CONCLUSIONS: The magnetically adjustable version of this IOL is a viable and promising means of handling the common issues of postoperative refractive errors without the requirement of additional surgery. The repeatedly adjustable mechanism of this lens also holds promise for the developing eyes of pediatric patients and the changing needs of all patients.

Biocompatible Materials↗

Development of a repeatedly adjustable intraocular lens.

PURPOSE: To provide a variable-focus intraocular lens (IOL) that is able to adjust repeatedly and reversibly. SETTING: University of Missouri-Rolla, Rolla, and Eggleston Adjustable Lens, St. Louis, Missouri, USA. METHODS: An adjustable IOL based on a mechanically adjustable design has been developed. Prototypes were fabricated from traditional Perspex CQ poly(methyl methacrylate) (PMMA) provided off the shelf by a current IOL manufacturer. The prototypes have undergone proof-of-concept testing per the requirements of National Institutes of Health grant 1 R41 EY13482-01, with specific attention to the feasibility and safety of continuing development of the lens with in vivo trials. The experimental results presented focus on operational force measurements. RESULTS: Prototype lenses were produced consistently. Operational force measurements indicated that use of the mechanical adjustment mechanism is viable for an adjustable IOL and provides repeated adjustments over time. Turning forces exhibited by the prototypes were low enough to suggest that operation of this adjustable IOL will not damage the capsular bag or ciliary body of the eye, a potential concern in using this design. Biocompatibility and optical quality of the prototype lenses are ensured by use of traditional Perspex CQ PMMA. CONCLUSIONS: The mechanically adjustable IOL provides a feasible and promising means of confronting postoperative refractive errors and the changing desires of patients. The viability of this IOL design has been proven, and results suggest that operation of the lens is safe enough to pursue in vivo trials. Evaluation of the biocompatibility of the lens architecture as well as the ultimate goal of noninvasive adjustment using this model are reported in a companion article.

Biocompatible Materials↗