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Michal Zochowski

Publications and source records attributed to Michal Zochowski.

4 recordsLinked to original sources
PubMed2006

Network reorganization driven by temporal interdependence of its elements.

We employ an adaptive parameter control technique based on detection of phase/lag synchrony between the elements of the system to dynamically modify the structure of a network of nonidentical, coupled Rossler oscillators. Two processes are simulated: adaptation, under which the initially different properties of the units converge, and rewiring, in which clusters of interconnected elements are formed based on the temporal correlations. We show how those processes lead to different network structures and investigate their optimal characteristics from the point of view of resulting network properties.

Action Potentials↗
PubMed2006

Changing roles for temporal representation of odorant during the oscillatory response of the olfactory bulb.

It has been hypothesized that the brain uses combinatorial as well as temporal coding strategies to represent stimulus properties. The mechanisms and properties of the temporal coding remain undetermined, although it has been postulated that oscillations can mediate formation of this type of code. Here we use a generic model of the vertebrate olfactory bulb to explore the possible role of oscillatory behavior in temporal coding. We show that three mechanisms--synaptic inhibition, slow self-inhibition and input properties--mediate formation of a temporal sequence of simultaneous activations of glomerular modules associated with specific odorants within the oscillatory response. The sequence formed depends on the relative properties of odorant features and thus may mediate discrimination of odorants activating overlapping sets of glomeruli. We suggest that period-doubling transitions may be driven through excitatory feedback from a portion of the olfactory network acting as a coincidence modulator. Furthermore, we hypothesize that the period-doubling transition transforms the temporal code from a roster of odorant components to a signal of odorant identity and facilitates discrimination of individual odorants within mixtures.

Animals↗
PubMed2002

Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.

Intracellular calcium signals have distinct temporal and spatial patterns in neurons in which signal initiation and repetitive spiking occurs predominantly in the neurite. We investigated the functional implications of the coexpression of different isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using immunocytochemistry, Western blotting, and calcium imaging in neuronally differentiated PC12 cells. InsP3R type III, an isoform that has been shown to be upregulated in neuronal apoptosis, is exclusively expressed in the soma, serving as a gatekeeper for high-magnitude calcium surges. InsP3R type I is expressed throughout the cell and can be related to signal initiation and repetitive spiking in the neurite. RyR types 2 and 3 are distributed throughout the cell. In the soma, they serve as amplifying molecular switches, facilitating recruitment of the InsP3R type III-dependent pool. In the neurite, they decrease the probability of repetitive spiking. Use of a cell-permeant analog of InsP3 suggested that regional specificity in InsP3 production and surface-to-volume effects play minor roles in determining temporal and spatial calcium signaling patterns in neurons. Our findings suggest that additional modulatory processes acting on the intracellular channels are necessary to generate spatially specific calcium signaling.

Animals↗