Biomedical subjects

Michele King

Publications and source records attributed to Michele King.

3 recordsLinked to original sources

PubMed2004

Process evaluation: how it works.

Process evaluation helps us to understand the planning process. This predominantly qualitative approach explains how and why decisions are made and activities undertaken. The focus includes feelings and perceptions of program staff. The evaluator's ability to interpret and longitudinally summarize the experience of program staff and community members is critical. Techniques discussed include participant observation, content analysis, situational analysis, in-house surveys, and interviews. By combining sources and methods, a fuller picture of the process is revealed.

Attitude of Health Personnel↗

PubMed2004

Developing a plan for measuring outcomes in model systems of care for American Indian and Alaska Native children and youth.

The Circles of Care initiative emphasized the importance of developing an outcomes measurement plan that was consonant with the model system of care as well as community values and priorities. This analysis suggests that the Circles of Care grantees achieved this key programmatic objective, but that a major constraint was the tendency of funders, including the Substance Abuse and Mental Health Services Administration (the funder of Circles of Care), to mandate their own outcomes measurement plans. Funders are encouraged to balance their needs for commonality of measures across programs for their own evaluation purposes with the needs of service providers to utilize measures that meet their unique programmatic and community contexts.

Adolescent↗

PubMed2002

Vitamin E inhibits melanoma growth in mice.

BACKGROUND: Previous work has demonstrated that vitamin E succinate (VES), an ester analogue of vitamin E, inhibits the growth of melanoma in vitro. However, there is no information about the effect of VES on melanoma in vivo. We investigated the effect of VES on melanoma in vitro and in vivo. METHODS: The effect of VES on the proliferation and apoptosis of the B16F10 murine melanoma cell line was determined by a modified Cell Titer 96 AQ assay and a cell death detection enzyme-linked immunosorbent assay, respectively. The in vivo effect of VES on B16F10 melanoma cells allografted in athymic nude mice was investigated. The mechanism of the in vivo antitumor effect of VES was determined by immunohistochemical detection of proliferation and apoptosis. RESULTS: VES decreased cell proliferation (P =.0001) and increased cell apoptosis (P =.0001) in a dose-dependent manner in vitro. Also, VES significantly inhibited melanoma growth in mice (P =.0013). The VES antitumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate (P =.0256). CONCLUSIONS: This is the first report of the antimelanoma effect of VES in vivo. The mechanism of the antimelanoma effect of VES in vivo involves the promotion of tumor cell apoptosis. These findings support future investigations of VES as a therapeutic micronutrient against melanoma.

Animals↗