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Biomedical subjects

Michele Lanza

Publications and source records attributed to Michele Lanza.

13 recordsLinked to original sources
PubMed2006

Anterior chamber depth measurement before and after photorefractive keratectomy: comparison between IOL master and Orbscan II.

PURPOSE: To measure the anterior chamber depth (ACD) with 2 different devices before and after photorefractive keratectomy (PRK). DESIGN: Noncomparative case series. PARTICIPANTS: One hundred forty-three eyes of 143 patients who had undergone PRK with refractive errors ranging from -13.13 diopters (D) to +7 D (mean, -3.67+/-3.58) were analyzed. METHODS: The ACD values preoperatively and at 1, 3, and 6 months postoperatively were measured with the Orbscan II and IOL Master. The results were analyzed using the Pearson correlation. MAIN OUTCOME MEASURE: Anterior chamber depth. RESULTS: The instruments showed good agreement between the measurements before and after surgery. A significant decrease between the preoperative and 1-month postoperative measurements was found in the ACD measured from the epithelium with Orbscan II (P<0.01) and IOL Master (P<0.01). A nonsignificant decrease with both IOL Master (P>0.01) and Orbscan II (P>0.01) was found between 3 and 6 months after surgery. The ACD measured from the endothelium using the Orbscan II showed a significant difference only between the 3- and 6-month follow-up data (P<0.01). CONCLUSIONS: The 2 devices showed good agreement, and the changes detected postoperatively seem to be related not only to corneal thinning but also to anterior segment remodeling.

Adolescent↗
PubMed2005

Reliability of a new correcting factor in calculating intraocular lens power after refractive corneal surgery.

PURPOSE: To test the reliability of a corneal radius correcting factor (R factor) in calculating intraocular lens (IOL) power in eyes that developed cataract after refractive surgery and compare it with the clinical history (CHM) and double-K (DKM) methods. SETTING: Department of Ophthalmology, Second University of Naples, Naples, Italy. METHODS: Nineteen eyes from the literature that underwent cataract extraction and IOL implantation after refractive surgery were used to compare actual postoperative and expected refractive errors utilizing the R factor, CHM, and DKM. Intraocular lens powers were calculated with 3 formulas: SRK/T, Hoffer Q and Holladay 1. The differences were evaluated with the Wilcoxon test and Spearman correlation. RESULTS: With the R factor SRK/T and Holladay 1 formulas gave the best results; 16 (84.2%) and 17 (89.5%) eyes were within +/-2 diopters (D) of emmetropia. With CHM, the best results were obtained using the SRK/T and Holladay 1 formulas; with both formulas 12 (63.2%) eyes were within +/-2 D of emmetropia. With DKM, the best results were obtained using SRK/T and Holladay 1 formulas; with both formulas 10 eyes (52.63%) were in the range of +/-2 D from emmetropia. CONCLUSIONS: The R factor can be used with the SRK/T or Holladay 1 formula because this method seems comparable or superior to DKM and CHM.

Cataract Extraction↗
PubMed2005

Slime-producing Staphylococcus epidermidis and S. aureus in acute bacterial conjunctivitis in soft contact lens wearers.

In recent years, an increase in ocular pathologies related to soft contact lens has been observed. The most common infectious agents were Staphylococcus spp. Some strains produce an extracellular polysaccharidic slime that can cause severe infections. Polysaccharide synthesis is under genetic control and involves a specific intercellular adhesion (ica) locus, in particular, icaA and icaD genes. Conjunctival swabs from 97 patients with presumably bacterial bilateral conjunctivitis, wearers of soft contact lenses were examined. We determined the ability of staphylococci to produce slime, relating it to the presence of icaA and icaD genes. We also investigated the antibiotic susceptibility and Pulsed Field Gel Electrophoresis (PFGE) patterns of the clinical isolates. We found that 74.1% of the S. epidermidis strains and 61.1% of the S. aureus strains isolated were slime producers and showed icaA and icaD genes. Both S. epidermidis and S. aureus slime-producing strains exhibited more surface hydrophobicity than non-producing slime strains. The PFGE patterns overlapped in S. epidermidis strains with high hydrophobicity. The similar PFGE patterns were not related to biofilm production. We found scarce matching among the Staphylococcus spp. studied, slime production, surface hydrophobicity and antibiotic susceptibility.

Adolescent↗
PubMed2004

Reliability of the IOLMaster in measuring corneal power changes after photorefractive keratectomy.

PURPOSE: To test the accuracy of the IOLMaster (Carl Zeiss) in detecting corneal power changes after photorefractive keratectomy (PRK). SETTING: Department of Ophthalmology, 2nd University of Naples, Naples, Italy. METHODS: Two hundred twenty-five consecutive eyes that had PRK (mean -5.13 diopters [D] +/- 2.98 [SD] [range +0.25 to -16.25 D]) were analyzed. The data included preoperative and postoperative (1, 3, and 6 months) subjective refraction and computerized keratometry. Statistical analysis was performed to determine the correlation between the changes in the subjective refraction at the corneal plane and the changes in keratometry. RESULTS: The mean difference between the changes in refraction and the measured corneal changes was 0.75 +/- 1.13 D (range -3.84 to +7.68 D) at 1 month, 0.92 +/- 1.10 D (range -0.87 to +7.93 D) at 3 months, and 0.75 +/- 0.98 D (range -1.70 to +3.85 D) at 6 months. The difference was significant (P<.001). CONCLUSION: Automated keratometry provided by the IOLMaster did not accurately reflect the effective refractive changes after PRK, particularly in eyes that had a high dioptric treatment.

Adult↗
PubMedDate not supplied

Anterior corneal surface after Nidek EC-5000 multipass and multizone photorefractive keratectomy for myopia.

PURPOSE: To evaluate the correlation between the presence of irregularities in corneal ablation and the number of ablation zones with multipass and multizone photorefractive keratectomy (PRK). METHODS: The differential maps obtained from corneal topography performed before and 1 month after PRK in 62 eyes that had undergone PRK with the Nidek EC-5000 excimer laser were assessed for irregularities. PRK treatment ranged from -1.00 to -16.00 D (mean -5.25 +/- 2.72 D), and the number of zones ranged from one to five. RESULTS: Of 62 differential maps, 27 had an irregular pattern according to the Hersh classification, with a non-significant correlation with the number of treatment zones (chi2 = 5.09, P >.1). CONCLUSION: Our results suggest that corneal topography irregularities arising from multizone PRK were not related to the amount of treatment or to the number of ablation zones.

Adult↗
PubMedDate not supplied

Correlation of changes in refraction and corneal topography after photorefractive keratectomy.

PURPOSE: To establish which corneal power evaluation measured with corneal topography correlates best with refractive changes after photorefractive keratectomy (PRK) for myopia. METHODS: Two hundred fifty-one consecutive eyes of 171 patients who had PRK for myopia ranging from -14.80 to -0.50 D (mean -5.43 +/- 2.978 D), calculated at the corneal plane, were included in the analysis. Data included preoperative and postoperative (1, 3, and 6-mo) subjective refraction and videokeratography with a Keratron Scout (Optikon 2000). Statistical analysis was performed to determine the correlation between the change in subjective refraction at the corneal plane and changes in six corneal power measurements: best fit sphere, simulated keratometry (Sim K), corneal apex, and center of the pupil (last two evaluated for axial and meridional curvatures). RESULTS: The closest correlation between subjective refraction change and corneal power measurement during the three follow-up evaluations was found with Sim K (R2 = 0.904; 0.889; 0.854) and best fit sphere (R2 = 0.919; 0.909; 0.872), whereas the other measurements showed poor correlation with the different curvatures. CONCLUSIONS: The best fit sphere corneal topography parameter correlated best with the refractive changes, primarily for low treatment amounts, whereas it showed a clear-cut underestimation in eyes that had undergone high dioptric treatments.

Adult↗
PubMedDate not supplied

Axial eye length evaluation before and after myopic photorefractive keratectomy.

PURPOSE: To test the accuracy of a new device (IOL Master; Carl Zeiss, Jena, Germany) in detecting axial eye length changes after photorefractive keratectomy (PRK). METHODS: Pre- and postoperative (1, 3, and 6 months) subjective refraction and axial eye length measurements were performed in 184 consecutive eyes that underwent PRK with the Nidek EC5000 excimer laser (Nidek Technologies, Gamagori, Japan) to treat refractive errors from +0.25 to -16.25 diopters (D) (mean: -5.12 +/- 3.01 D). RESULTS: The axial eye length measurements ranged from 22.51 to 31.32 mm (mean: 25.61 +/- 1.47 mm) before PRK; from 22.39 to 31.10 mm (mean: 25.48 +/- 1.43 mm) 1 month after PRK; from 23.17 to 31.14 mm (mean: 25.61 +/- 1.36 mm) 3 months after PRK; and from 23.36 to 29.68 mm (mean: 25.58 +/- 1.35 mm) 6 months after PRK. Preoperative and 1-month postoperative data showed a statistically significant difference (P<.001), whereas no significant difference was found between 1 and 3 months (P=.0137) or 3 and 6 months (P=.2422). CONCLUSIONS: The IOL Master showed a decrease in the axial eye length measurement larger than the theoretical ablation depth and the difference increased as the correction became higher.

Adolescent↗