Biomedical subjects

Miguel A Rosales

Publications and source records attributed to Miguel A Rosales.

3 recordsLinked to original sources

PubMed2006

Multislice CT coronary angiography for the detection of burden, morphology and distribution of atherosclerotic plaques in the left main bifurcation.

The aim of the study was to explore the differences in plaque burden at different segments of the left main bifurcation and its relationship with the bifurcation angle using high-resolution multislice CT coronary angiography (MSCT). Patients were evaluated using a 40-row MSCT scanner. One observer assessed the localization, severity and distribution of plaques within the left main (LMCA) bifurcation, whereas another observer defined the angle. Fifty patients were included. The mean heart rate was 59.8 +/- 7.1. Seventeen (34%) patients presented at least wall irregularities in the LMCA and in the ostial LCx, whereas the ostial LAD was affected in 32 (64%) patients. More than 90% of plaques were located opposite to the flow divider. The median bifurcation angle was 88.5 degrees (IQR 68.8 degrees, 101.4 degrees). Of the 18 patients with a normal ostial LAD, 13 (72%) had a bifurcation angle < 88.5 degrees , whereas the 63% of the patients with any LAD disease had an angle >or= 88.5 degrees (P = 0.018). In conclusion, at the left main bifurcation, atherosclerotic plaques are commonly located at the ostial LAD and opposite to the flow divider. The angle of the left main bifurcation and the presence of plaques within the bifurcation are closely related.

Chi-Square Distribution↗

PubMed2006

Modified scan protocol using multislice CT coronary angiography allows high quality acquisitions in obese patients: a case report.

Nearly every cardiovascular functional imaging technique has difficulties in dealing with obese patients and MSCT-CA is not an exception. Excluding such large portion of the coronary population remains a grim limitation of the technique and requires thus a comprehensive re-evaluation. In this report, we show that excellent image quality could be achieved in a morbidly obese patient with the aid of proper management of scan protocols and bolus administration. Providing this complex population an accurate, non-invasive imaging technique represents a major step-forward in cardiovascular imaging.

Contrast Media↗

PubMed2005

Grafting between tobacco plants to enhance salinity tolerance.

We analysed the technique of grafting as a tool to increase salt-stress resistance in tobacco plants. With this aim, we performed two experiments. First, we selected, from among 6 commercial tobacco cultivars (cv. BB-162, cv. H-20, cv. Jarandilla, cv. ZB-3, cv. Havana II and cv. Havana 307) those most tolerant and sensitive to salinity, studying the response of certain nutritional and biochemical indicators of resistance in these plants. In the second experiment, we analysed the response to salinity in grafted tobacco plants using the rootstock of the most tolerant plants, and the scion of the most sensitive ones. In addition, these plants were subjected to salinity to test the viability and efficiency of this grafting technique, assessing the production of foliar biomass and the different quality parameters in this crop. In the first experiment, we found that the most tolerant tobacco cultivars were cv. BB-162 and cv. H-20, which were characterized by reduced uptake and foliar accumulation of Na(+) and Cl(-), together with greater synthesis of sucrose and proline, thereby reducing lipid peroxidation and thus oxidative damage, reflected in higher foliar biomass with respect to the other cultivars studied (primarily cv. Jarandilla, defined as the most salt-sensitive). In the second, we demonstrated that the grafting of salt-sensitive tobacco scions to salt-tolerant rootstocks improves the production and quality of tobacco leaves under conditions of saline stress. Our results show that the rootstocks cv. BB-162 and cv. H-20 best induced salt resistance in tobacco cv. Jarandilla, registering the lowest foliar concentrations of Na(+) and Cl(+), the lowest lipid peroxidation, and the highest proline and sugar concentrations. Overall, this is reflected in better biomass production and quality of the aerial part of the plant.

Adaptation, Physiological↗