PubMed Health⌕ Search

Biomedical subjects

Mikako Inokuchi

Publications and source records attributed to Mikako Inokuchi.

6 recordsLinked to original sources
PubMed2006

Age-dependent percentile for waist circumference for Japanese children based on the 1992-1994 cross-sectional national survey data.

The aim of this study was to set forth an age-dependent percentile for waist circumference of Japanese children and to compare the reference with data from other countries. We utilized the 1992-1994 cross-sectional national survey data on waist circumference as measured at two benchmark sites in 10,614 Japanese children (5,851 boys, 4,763 girls) aged 6.0-18.0 years for constructing the reference by the LMS method. Japanese children had smaller waist circumference percentile values as compared to those of Dutch and US children, but had comparable or larger percentile values as compared to those of UK children. We suspect that the observed ethnic differences may be in part due to the differences in benchmark in waist circumference measurements in each country. We present for the first time an age-dependent percentile for waist circumference for Japanese children. It is mandatory to standardize a benchmark site for waist circumference for more meaningful international comparison.

Adolescent↗
PubMed2004

Genetic testing of glycogen storage disease type Ib in Japan: five novel G6PT1 mutations and a rapid detection method for a prevalent mutation W118R.

We devised a simple method using a TaqMan fluorogenic probe for detection of a prevalent G6PT1 mutation W118R among Japanese patients with glycogen storage disease type Ib. The W118R mutation was detected in three of six newly diagnosed Japanese patients. The W118R-negative alleles were screened for causative mutations by sequencing analysis, revealing five novel mutations. The genetic tests using the simple TaqMan method coupled with sequencing analysis would facilitate the early diagnosis of this disorder.

Adult↗
PubMed2002

Growth pattern and body proportion in a female with short stature homeobox-containing gene overdosage and gonadal estrogen deficiency.

OBJECTIVE: To report on growth pattern and body proportion in the combination of short stature homeobox-containing gene (SHOX) overdosage and gonadal estrogen deficiency. DESIGN: Auxological studies in a 20-year-old Japanese female with 45,X[28]/46,X,psu idic(X)(q28)[72], gonadal estrogen deficiency, and SHOX duplication on the idic(X) chromosome, who received sex steroid replacement therapy from 16 years 8 months of age. METHODS: Growth pattern and body proportion were assessed by the age-matched standards for Japanese females. RESULTS: She continued to grow with a mean height velocity of 5.0 cm/year between 8 and 12 years of age and 4.4 cm/year between 12 and 16 years 8 months of age, and ceased to grow shortly after the replacement therapy. The standard deviation score (SDS) for height was -0.9, -1.4, +0.7 and +0.8 at 8, 12, 16 years 8 months and 20 years of age respectively. She showed a unique change in body proportion in her middle teens. At 8, 12, 16 years 8 months and 20 years of age, the SDS for sitting height (SH) was -0.8, -1.1, -0.9 and -0.6 respectively, the SDS for leg length (LL) was -1.2, -1.4, +1.1 and +1.4 respectively, and the SDS for SH/LL ratio was +0.6, +0.4, -1.6 and -1.7 respectively. CONCLUSIONS: The results provide further support for the notion that the combination of SHOX overdosage and gonadal estrogen deficiency permits continued growth with a roughly constant height velocity throughout the pubertal period of normal children, and suggest that the height gain in that period is primarily ascribed to the LL increase, as expected from SHOX expression in the distal limb bones.

Adult↗
PubMedDate not supplied

Standardized centile curves of body mass index for Japanese children and adolescents based on the 1978-1981 national survey data.

BACKGROUND: The prevalence of overweight among Japanese children and adolescents has steadily increased during the last 20 years. Thus, we utilized the 1978-1981 data collected by the Japanese Ministry of International Trade and Industry to construct reference curves of body mass index (BMI) for contemporary Japanese children and adolescents. METHODS: BMI reference values were derived using the LMS method as based on height and weight data from the cross-sectional national survey of Japanese children and adolescents conducted in 1978-1981 (14,012 boys and 13 781 girls, aged 1.5-18.5 years). RESULTS: The Japanese BMI reference curves were constructed for clinical use. The centile values at the upper end of the spectrum apparently differed in British, Dutch, Japanese, and US children and adolescents. In contrast, the centile values at the lower end of the spectrum nearly overlapped with each other in the four populations. CONCLUSIONS: Overweight is concentrated in a subgroup of children and does not occur across the entire population of British, Dutch, Japanese, and US children, indicating a subgroup of genetically and/or environmentally more susceptible children in each country.

Adolescent↗