Biomedical subjects
Publications and source records attributed to Mike Allen.
Bisaryl cyclic ureas have been identified as high affinity 5-HT2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.
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Despite considerable awareness amongst the healthcare community about the importance of hand hygiene in controlling Healthcare Acquired Infections (HAIs), the problem persists. Mike Allen of Dart Valley Systems explores the issues surrounding good hand hygiene practice in UK hospitals.
Well-known literature reviews from the 1960s question whether cognitive dissonance underlies experimental participants' selective exposure of themselves to consonant messages and avoidance of dissonant ones. A meta-analytic review of 16 studies published from 1956 to 1996 and involving 1,922 total participants shows that experimental tests consistently support the supposition that dissonance is associated with selective exposure (r = .22, p < .001). Statistical power exceeded .99. Advances in statistical methodology and increased attention to selecting appropriate tests of dissonance theory were essential to finally resolving this question.
This meta-analysis summarizes the available data concerning the impact that the public announcement that Earvin "Magic" Johnson, a National Basketball Association All-Star, had tested positive for HIV. The results demonstrate that the announcement increased the level of accurate knowledge in persons, the number of persons getting tested for HIV, and the desire to obtain more information about HIV and AIDS. For adults the impact of the announcement was to increase the perception of vulnerability while for children/adolescents the announcement diminished the perception of risk.