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Biomedical subjects

Mindy B Tinkle

Publications and source records attributed to Mindy B Tinkle.

5 recordsLinked to original sources
PubMed2002

Mitochondrial disorders: a clinician's primer.

Mitochondrial disorders represent an extremely challenging set of conditions, partly due to the complexities of the mitochondrial genetic system. Nurses must be prepared with knowledge about genetic conditions so that they can participate fully in early identification of affected individuals and assist them in accessing the most current genetic diagnostic and treatment therapeutics. This knowledge will be critical as nurses collect family history data, provide current and accurate genetic information and support to individuals and families, and refer to and collaborate with genetic specialists in their communities.

Adult↗
PubMedDate not supplied

Stages of change, processes of change, and social support for exercise and weight gain in postpartum women.

OBJECTIVES: To test the extent to which social support and variables included in the Transtheoretical Model were explanatory for exercise initiation and weight maintenance in postpartum women. DESIGN: A cross-sectional descriptive design. SETTING: Data were collected in the participant's homes. PARTICIPANTS: Postpartum women who had normal pregnancies were interviewed and measured on body fat, physical activity, and psychosocial scales. MAIN OUTCOME MEASURE: (a) Stages of exercise change measure, (b) Seven Day Recall, (c) Friend and Family Support for Exercise Scale, (d) Processes of Change Questionnaire, and (e) body fat measures including body mass index and percent body fat. RESULTS: Forty percent reported engaging in vigorous activity less than 1 hour daily, 55% walked less than four city blocks daily, and 52% engaged in less than 2 hours of vigorous weekend activity. Multilinear regression showed that the processes of change contributed 36% to the body mass index, and 21% of the variance in waist-thigh ratio. Of the processes of change, environmental reevaluation correlated significantly with body mass index. CONCLUSION: The impact of a woman's weight on others as well as information concerning the health effects of obesity and physical activity could enhance the initiation of exercise in the postpartum woman.

Adaptation, Psychological↗
PubMedDate not supplied

Spinal muscular atrophy in the neonate.

Spinal muscular atrophy (SMA) type I is an autosomal recessive disorder characterized by loss of lower motor neurons in the spinal cord. This severe hereditary neurodegenerative disorder is an important cause of morbidity in the neonate and the leading hereditary cause of infant mortality. The characteristic degeneration of anterior horn cells in the spinal cord leads to progressive muscular weakness and atrophy of the skeletal muscles. In SMA type I, the most severe form of SMA, death usually ensues by 2 years of age from respiratory failure or infection. Accurate diagnosis is now available through genetic testing, and progress is being made toward the development of therapy based on understanding of the disease mechanism. The neonatal nurse plays a pivotal role in identifying and caring for these medically fragile infants and in providing support and education for parents and families.

Chromosome Deletion↗
PubMedDate not supplied

Human genomics: challenges and opportunities.

The pace of knowledge development related to genetics continues to progress exponentially. Knowledge gained through the Human Genome Project will have a profound impact on the practice of nursing, and the widespread integration of genetics into nursing education, clinical practice, and research will be essential. Many nurses continue to view genetic services as relegated to a specialist in a tertiary center and not relevant to their practice. This is certainly about to change. This article reviews the major implications of Human Genome Project for changing the landscape of health care and nursing, discusses several specific examples of genetic testing, and describes strategies under way to help prepare nurses to meet these new demands. Understanding new DNA-based genetic-testing technologies will be important for nurses as these tests become more available and nurses assist clients in the management of their genetic health. Nurses must become active participants in embracing the challenges and opportunities related to this genetic revolution, which over the next 5 to 10 years will reach nurses in every specialty and in every practice setting.

Curriculum↗