Biomedical subjects

Minori Miyake-Kashima

Publications and source records attributed to Minori Miyake-Kashima.

7 recordsLinked to original sources

PubMed2006

Quantitative evaluation of the early changes in ocular surface inflammation following MMC-aided papillary resection in severe allergic patients with corneal complications.

BACKGROUND: Atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) are chronic inflammatory allergic diseases that are associated with some common conjunctival and corneal complications.1 The clinical corneal manifestations of both entities may include superficial punctate keratitis, macroerosions, corneal ulceration, plaque formation, corneal neovascularization, and lipid infiltration. PURPOSE: To quantitatively evaluate the early ocular surface inflammation before and after mitomycin C (MMC)-aided papillary resection in severe allergy patients with corneal complications. METHODS: Three eyes with VKC and 5 eyes with AKC were included in this study. All eyes had cobblestone-like papillae on the upper tarsal conjunctiva and corneal complications such as corneal ulcers, defect, or erosions that were refractory to conventional treatment of more than 2 weeks. Papillary resection with intraoperative 0.05% MMC application for 5 minutes on the palpebral conjunctiva was carried out in all eyes. Corneal and conjunctival findings were evaluated before and 1 week and 2 weeks after surgery. Brush cytology (BC) and evaluation of tear eosinophilic cationic protein (ECP) levels by radioimmunoassay techniques were performed as well pre- and postoperatively. RESULTS: Corneal and conjunctival complications resolved in all patients within 7 days after resection. Postoperative tear ECP levels decreased significantly with papillary resection (P< 0.05). Concomitant brush cytology showed a significant decrease in the number of eosinophils and neutrophils following papillary resection (P < 0.05). CONCLUSION: MMC-aided papillary resection provided a dramatic decrease in ocular surface inflammation as evidenced by decrease in the number of inflammatory cells as well as tear ECP levels with a rapid improvement of clinical corneal and conjunctival findings.

Adolescent↗

PubMed2005

Observation of the corneal flap interface with metal particles in a rabbit model.

PURPOSE: To observe changes, such as diffuse lamellar keratitis, at the corneal interface when metal particles from microkeratome blades were left in rabbit eyes. SETTING: Department of Ophthalmology, Tokyo Dental College, Suidobashi Hospital, Tokyo, Japan. METHODS: Following the creation of a corneal flap with microkeratome, metal particles from a microkeratome blade were placed at the corneal interface in 14 rabbit eyes. Microscopic and histopathologic changes were compared with those in the control eyes (n = 4), which did not receive any metal particles. Each examination was conducted at 3 days, 2 weeks, and 1 and 3 months postoperatively. The change in the depth of the metal particles was also measured. RESULTS: Slitlamp examination did not show an inflammatory reaction or corneal opacification in any eye (100%) with metal particles at the flap interfaces. Histopathologic examinations showed no obvious changes at the flap interfaces or around the metal particles in any eye. CONCLUSION: Inflammatory reactions, such as diffuse lamellar keratitis, do not appear to be induced by metal particles from the microkeratome blade itself.

Animals↗

PubMed2005

The effect of antireflection film use on blink rate and asthenopic symptoms during visual display terminal work.

PURPOSE: To investigate the effect of visual display terminal antireflection (AR) films on blink rate and subjective symptoms of asthenopia. METHODS: This was a nonrandomized, prospective clinical trial in which 7 healthy volunteers underwent blink rate measurements with a blink rate recording system while viewing a DVD on a computer display for 10 minutes. The measurements were carried out without an AR film on terminal displays initially. The same tasks were performed on the next day with an AR film on the displays. The subjects were also required to score their symptoms of asthenopia on a visual analog scale before and just after DVD viewing. The changes in blink rate and asthenopia scores with AR film use were assessed by the Student t test. RESULTS: The mean baseline blink rate was 15.7 +/- 5.9 blinks /min, which decreased significantly to 9.6 +/- 4.3 blinks/min after DVD viewing without an AR film (P < 0.05). The mean baseline and final blink rates for DVD viewing with an AR film were 14.6 +/- 9.2 and 14.3 +/- 9.2 blinks/min, respectively. There were no significant differences between baseline and final blink rates after DVD viewing with an AR film (P > 0.05). The mean cumulative visual analog asthenopic symptom score after DVD viewing without an AR film was 72 +/- 18% compared with the mean cumulative symptom score of 52 +/- 11% after DVD viewing with an AR film. The difference was statistically significant (P < 0.05). CONCLUSIONS: Visual display terminal work appears to be associated with asthenopic symptoms and decreased blink rates. The use of AR films on computer displays may prevent both reflections of light from screen surfaces and reduction in blink rates resulting in fewer asthenopic symptoms.

Adult↗

PubMed2004

Kaposi varicelliform eruption associated with 0.1% tacrolimus ointment treatment in atopic blepharitis.

OBJECTIVE: To report the association of Kaposi varicelliform eruption (KVE) with 0.1% tacrolimus ointment treatment of atopic blepharitis in a patient with atopic dermatitis (AD). METHOD: We encountered KVE in a 20-year-old male patient with atopic blepharitis and AD who developed generalized herpetic lesions on his face 28 days after commencement of treatment. RESULT: The lesions resolved quickly with intravenous acyclovir treatment. CONCLUSION: Ophthalmologists should be well aware of KVE as a complication of immunosuppressive treatment in patients with atopic blepharitis.

Acyclovir↗

PubMed2004

The relation of conjunctival and corneal findings in severe ocular allergies.

OBJECTIVE: Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. METHODS: Thirty eyes of 6 patients with vernal keratoconjunctivitis (VKC) and 13 patients with atopic keratoconjunctivitis (AKC) were evaluated in this study. Slit-lamp photographs of upper tarsal conjunctiva and cornea were used to evaluate the clinical findings objectively. The corneal findings and clinical findings of upper tarsal conjunctiva such as conjunctival injection, edema, the height of papillae, and mucous discharge were evaluated and graded. Statistical correlations between conjunctival findings and the severity of corneal damage were analyzed. RESULTS: Conjunctival injection and edema significantly correlated with the severity of corneal complications. The height of the papillae and the amount of mucous discharge did not correlate with the severity of corneal complications. CONCLUSION: Direct signs of inflammation such as injection and edema correlated with corneal damage. The height of papillae did not show a significant correlation with the corneal findings. Our results suggest that inflammation of the conjunctiva rather than mechanical factors may play a greater role in the formation of corneal damage in severe ocular allergies.

Adolescent↗

PubMed2004

Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report.

PURPOSE: To present a case of allergic corneal ulcer in a patient with atopic keratoconjunctivitis (AKC) that was persistent for 6 months and healed by amniotic membrane patching. CASE REPORT: A 27-year-old male patient with a corneal ulcer associated with AKC persistent for 6 months despite conventional treatment underwent amniotic membrane patching. On removal of the amniotic membrane patch after 1 week, the corneal ulcer that had been persistent for 6 months had healed completely. CONCLUSION: We experienced a case with corneal ulcer that was persistent for 6 months and healed dramatically within 1 week with improved vision and corneal clarity. In such severe and persistent cases requiring rapid epithelialization, amniotic membrane should be considered as an adjunct to conventional therapy.

Adult↗

PubMedDate not supplied

Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis.

PURPOSE: We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients. METHODS: Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Bromfenac eye drops and the contralateral eye was treated with Pemirolast eye drops for 1 week. Subjective ocular symptoms and objective ocular signs evaluated by slit-lamp examination were scored and recorded before and after treatment. RESULTS: Both drugs significantly decreased ocular signs after 1 week, but not symptoms. No significant differences in subjective symptoms or objective signs were observed between the two drugs. Ten patients (45.5%) selected Bromfenac as more effective, nine patients (40.9%) selected Pemirolast, and three patients found no difference in efficacy between the two drugs. CONCLUSION: Bromfenac sodium is as safe and effective for the treatment of allergic conjunctivitis as pemirolast potassium.

Adolescent↗