Biomedical subjects

Minu Patel

Publications and source records attributed to Minu Patel.

4 recordsLinked to original sources

PubMed2004

Pupil staging and EEG measurement of sleepiness.

The goal of this multi-method study was to examine the validity (accuracy) of the pupillometric Alertness Level Test (ALT) as a physiologic measure of sleepiness. The study used a pooled-time series-correlation design with 16 untreated narcolepsy (8 F, 8 M), 16 untreated obstructive sleep apnea (OSA) (7 F, 9 M) and 16 healthy control (8 F, 8 M) subjects. Participants underwent EEG/polysomnography testing using standard Multiple Sleep Latency Test electrode placement concurrent with the 15 min pupillometric ALT. EEG data were examined to determine if theta power (4-7 Hz) increased during 2-s periods of proportional pupil size decreases (pupil Stage 1, 95% or more of maximal pupil size to Stage 4, 65-74% of maximal size). Printed EEG records also were visually scored. Self-report sleepiness measures included the Pittsburgh Sleep Quality Index, the Profile of Mood States and the Epworth Sleepiness Scale. Within subject groups, theta power ratios significantly increased across pupil stages for the sleep disorder groups but not for controls (theta activity increased 42% for narcoleptic and 36% for OSA subjects). Between subject groups, the amount of theta activity was significantly greater for narcoleptic and OSA subjects than that for controls. Visual EEG scoring and self-report measures were usually consistent with objective findings. The ALT is convenient, easily repeatable and less technically demanding than EEG sleepiness measures, and it deserves more comprehensive testing as a valid measure of sleepiness.

Adult↗

PubMed2002

Effect of auditory, tactile, visual, and vestibular intervention on length of stay, alertness, and feeding progression in preterm infants.

This study determined whether an auditory, tactile, visual, and vestibular intervention (ATVV) reduced the length of hospitalization of 37 preterm infants by increasing the proportion of alert behavioral states, thereby improving their feeding progression. Participants comprised 12 infants born between 23 and 26 weeks' gestation with normal head ultrasounds and 25 CNS-injured infants born between 23 and 31 weeks' gestation. Infants were randomly assigned to the control group (11 males, five females) or study group (seven males, 14 females) at 32 weeks' postconceptional age. ATVV intervention was administered to the study group for 15 minutes, twice daily, 5 days per week, from 33 weeks of age until discharge. The study group demonstrated increased alertness during the first 5 minutes of intervention, which was significantly correlated to length of stay (p<0.05). The proportion of nippled (teat) intake increased significantly faster for the study group (p=0.0001). Infants in the study group were discharged at a mean of 36.54 weeks, 1.6 weeks earlier than control infants (p<0.05). ATVV intervention facilitated increased alertness, faster transition to complete nipple feeding, and decreased length of hospitalization.

Acoustic Stimulation↗

PubMedDate not supplied

The coronary artery bypass experience: gender differences.

OBJECTIVE: The primary purpose of this study was to examine differences between women and men on physical, social and psychological domains of health quality of life before, 1 month after, and 3 months after coronary artery bypass surgery. DESIGN: A prospective, longitudinal design was used. SETTING: The study was conducted at a Midwestern, 500-bed community hospital with an ongoing cardiothoracic surgical program. PARTICIPANTS: Forty pairs of women and men matched on age within 5 years and body surface area within 0.1m 2. INSTRUMENTS: The physical, social and psychological domains of health quality of life were assessed using the following instruments: Ferrans and Powers Quality of Life Index, Specific Activity Scale, Symptom Scale, Profile of Mood States, Overall Health Rating Index, and Personal Resource Questionnaire. RESULTS: Both women and men improved on physical and psychological measures following coronary artery bypass surgery. Compared with men, women reported more shortness of breath and depression and lower ratings of activity, vigor, and overall health. Measures of social support yielded little information. CONCLUSIONS: Despite matching for age and body surface area, women did not have as favorable an outcome after surgery as men. Continued research needs to further examine the interaction of physical outcomes and depression in women after coronary artery bypass surgery.

Chi-Square Distribution↗

PubMedDate not supplied

Developmental patterns of physiological response to a multisensory intervention in extremely premature and high-risk infants.

OBJECTIVE: To compare the developmental patterns of heart rate (HR), respiratory rate (RR), and hemoglobin oxygen saturation (SaO2) of premature infants with and without central nervous system (CNS) injury, and evaluate whether a multisensory intervention altered this development. SAMPLE: Thirty-seven premature infants born at 23-26 weeks with normal head ultrasounds or at 24-32 weeks and diagnosed with periventricular leukomalacia (PVL) and/or intraventricular hemorrhage (IVH) were studied at 33-35 weeks postconceptional age. DESIGN: Infants were randomly assigned to control and experimental groups. The experimental group infants received auditory, tactile, visual, and vestibular (ATVV) multisensory intervention twice daily from 33 weeks postconceptional age (PCA) until hospital discharge. MAIN OUTCOME MEASURES: HR, RR, and SaO2 were continuously monitored during baseline, intervention, and the 30-minute postintervention period. RESULTS: Between 33 and 35 weeks PCA, control group infants with and without CNS injury and experimental group infants without CNS injury had a significant decrease in resting mean HR, whereas RR and SaO2 remained stable. The infants with PVL who received the intervention showed increases in HR even at rest. CONCLUSIONS: The absence of a weekly decline in HR for experimental group infants with PVL suggests that PVL may affect maturation of the autonomic nervous system and increase risk of decelerative HR changes and associated clinical compromise. Infants diagnosed with PVL should be closely monitored during procedures or interventions that may be stressful or involve handling. Further research is needed to tailor multisensory interventions for infants with PVL.

Acoustic Stimulation↗