Biomedical subjects

Mirosław Necki

Publications and source records attributed to Mirosław Necki.

3 recordsLinked to original sources

PubMed2003

[Laser doppler flowmetry--repeatability of the method].

The aim of the study was to evaluate the repeatability of flow microcirculation measurements by laser doppler flowmetry (Periflix, firm Perimed, Sweden). Measurements of right forearm skin perfusion were performed twice in 3-4 day intervals in 40 healthy subject aged 39.5 +/- 18.3. Two independent investigators analysed the results. Pearson correlation and analysis ac. Bland and Altman (Lancet 1986, 1, 307-310) were performed during comparing results obtained in the same studied persons and by the investigators. There was a high correlation between the compared results performed on the same subjects within a few days interval, especially between the results for post-occlusive congestion reaction in basic temperature (r = 0.64-0.72) and the results for congestion reaction at a temperature of 44 degrees C (r = 0.5-0.56). High correlation values (r = 0.8-0.95) were also observed when comparing both investigators' evaluations. Repeatability evaluation using Bland and Altman analysis was poorer, especially for values observed in resting conditions and for some values observed after stimulation with both investigators (2.5-10% of results were out of interval: mean +/- 2SD). The results show good repeatability of microcirculation flow measurements, especially under stimulation.

Adult↗

PubMed2002

[Vascular dementia and systemic changes].

The aim of the study was to evaluate risk factors of atherosclerosis and extra-cerebral target organ damage in patients with hypertension and vascular based mild memory disorders. A group of the study included 20 persons at age of 54-75 (8 males and 12 females) with mild vascular dementia (20-25 pts in MMSE, 22.8 +/- 1.73) with treated mild hypertension. A diagnosis of vascular dementia was confirmed in MRI by two independent experts. All examined patients presented multiinfarction changes in central nervous system as a cause of dementia. The study protocol contained present history, physical examination, 24-hour ambulatory blood pressure monitoring (ABPM), ECG, biochemical tests: total cholesterol, HDL-Ch, LDL-Ch, triglycerides, glucose, urea, creatinine plasma levels and urine test for microalbuminuria. In part of the study group (55%) echocardiography with posterior wall (PW) thickness and ejection fraction (EF) evaluation was performed. In the analysed group mean 24-hour blood pressure values were not elevated (SBP 130.8 +/- 15.8 mm Hg and DBP 77.6 +/- 9.2 mm Hg at day, respectively 121.6 +/- 17.1 mm Hg and 68.2 +/- 11.6 mm Hg at night). No significant (> 10%) nocturnal SBP decrease was observed, however DBP fall was noticed. Either total cholesterol (n < 5.2 mmol/l) or LDL-Ch (n < 3.5 mmol/l) plasma levels were increased in patients with vascular dementia and ranged respectively 5.8 +/- 0.9 and 3.7 +/- 0.9 mmol/l, HDL-Ch and triglycerides levels remained normal (respectively 1.7 +/- 0.5 and 1.5 +/- 1.1 mmol/l). Mean urea and creatinine levels were maintained in normal range (urea 5.8 +/- 1.7 mmol/l, creatinine 75.5 +/- 15.1 mumol/l). In a part of study group (35%) microalbuminuria was presented (urine albumine > 20 mg/l). In majority of patients with hypertension and vascular dementia a few risk factors co-existed. No systolic blood pressure decrease observed at night in 24-hour blood pressure monitoring, though normal mean values, can play an important role in vascular abnormalities progression.

Aged↗

PubMed2002

[Disturbances in microcirculation--an early predictor of arterial hypertension?].

The aim of this study was to assess microcirculation and properties of large arteries in healthy adult subjects. In 28 individuals between the ages of 21 and 49, the microcirculation in the skin at resting conditions and under stimulation (hyperaemic reaction after a 3-minute long ischaemia at basal body temperature and at 44 degrees C) was measured with laser doppler flowmetry detection. Pulse Wave Velocity was measured by using Complior device and average values of blood pressure were calculated. Subjects were divided into two groups based on the median (pLDF = 374.5) of the hyperaemic reaction after ischaemia at basal body temperature (14 persons in each group). There were no significant differences in the age and pulse wave velocity in both groups. The group after ischaemia at basal body temperature was characterized by significantly lower values of the resting flow, higher values of blood pressure, and higher values of increase in flow after ischaemia when compared to the group after ischemia at 44 degrees C. Furthermore, there was a positive correlation between values in flow after ischaemia at basal body temperature and at 44 degrees C with systolic blood pressure (r = 0.79 and 0.62, respectively). Presented results suggest that disturbances in microcirculation can precede development of hypertension.

Adult↗