Biomedical subjects

Misaki Ishioka

Publications and source records attributed to Misaki Ishioka.

4 recordsLinked to original sources

PubMed2006

Strip meniscometry: a new and simple method of tear meniscus evaluation.

PURPOSE: To investigate the applicability and efficacy of a new and simple method of quantification of the volume of tear meniscus, termed "strip meniscometry," in the diagnosis of the dry eye syndromes in a prospective controlled study. METHODS: One hundred eyes of 50 patients with dry eye (19 males; 31 females) aged between 18 and 76 years (mean, 54.3 years), as well as 80 eyes of 40 normal subjects aged from 15 to 70 years (mean, 50.8 years; 12 males, 28 females) were recruited in this study. The patients and the control subjects underwent strip meniscometry for 5 seconds, tear film lipid layer interferometry, tear film break-up time measurement, and ocular surface vital staining with fluorescein and rose bengal dyes and the Schirmer-1 test. RESULTS: Strip meniscometry scores correlated with tear quantity and stability, ocular surface staining scores, and lipid layer interferometry grades and improved after 2 weeks of punctal plug occlusion. CONCLUSIONS: Strip meniscometry is a swift, noninvasive, promising new method that is expected to find application in the diagnosis and evaluation of the outcome of treatment of dry eye syndromes.

Adolescent↗

PubMed2005

Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics.

PURPOSE: To demonstrate the effectiveness and safety of using viscoadaptive viscoelastics in deep lamellar keratoplasty (DLKP) for keratoconus. METHODS: A nonrandomized, comparative, interventional case series was performed on 12 eyes of 10 consecutive keratoconus patients without a history of acute hydrops. Patients were treated with DLKP using ophthalmic viscosurgical devices (OVDs) to dissociate Descemet membrane (DM) from the stroma before suturing of the donor cornea. Eight eyes were operated using Viscoat (dispersive), and 4 eyes were operated using Healon V (viscoadaptive). RESULTS: Six out of 8 eyes in the Viscoat group were successfully treated, and 2 eyes were converted to PKP because of tears in the DM. Another 3 eyes had double chambers as a result of perforations or tears in DM, which were treated by injecting air into the anterior chamber. All 4 eyes in the Healon V group were successfully operated, with 1 case with microperforation of DM during suturing. Healon V offered better control of the area to be dissociated and served as a pseudostroma that protects the exposed DM while the overlying stroma is maneuvered. CONCLUSION: Healon V is a valuable tool for performing DLKP in difficult cases such as keratoconus.

Adult↗

PubMed2004

Same-size donor corneas for myopic keratoconus.

OBJECTIVE: To determine the efficacy of using same-size donor grafts for keratoconus patients with axial myopia. METHODS: A prospective noncomparative interventional case series was performed on 142 eyes of 136 consecutive keratoconus patients. Penetrating keratoplasty (PKP) was performed by 3 skilled surgeons using the same technique with a single running 10-0 nylon suture. Donor button size was determined by a study protocol, where a same-size donor was used for eyes with an axial length (AXL) longer than 24.50 mm, whereas a 0.25-mm-oversized donor was used for eyes shorter than 24.49 mm. Postoperative spherical equivalent (SE) and incidence of postoperative complications were analyzed. RESULTS: Of the 142 consecutive eyes, 123 eyes were operated according to protocol. The average postoperative SE on last visit was -3.94 +/- 3.21 D, with an average uncorrected visual acuity of 0.28 (0.90 average corrected). Postoperative SE correlated inversely (r = 0.46) with preoperative axial length (AXL) expressed by the equation: SE = -0.15 (AXL)2+6.40 (AXL)-71.82. Graft rejection was observed in 7 eyes (5.7%), and glaucoma in 2 eyes that required surgery. CONCLUSIONS: Using same-size donor grafts in keratoconus patients with a long visual axis is a safe and effective procedure in reducing postoperative myopia.

Adolescent↗

PubMed2002

Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty.

PURPOSE: To prospectively compare the safety and efficacy of deep lamellar keratoplasty (DLKP) and penetrating keratoplasty (PKP). DESIGN: Prospective, randomized clinical trial. METHODS: Consecutive 26 eyes of 24 patients who had stromal opacity without endothelial abnormalities were randomly assigned to either PKP or DLKP. Best-corrected visual acuity (BCVA), contrast visual acuity, glare test, intraocular pressure, corneal topography, endothelial density, and pachymetry were measured before and after surgery. RESULTS: Two eyes in the DLKP had rupture of the Descemet membrane and one of the eyes developed endothelial decompensation. One eye in the PKP group showed decreases in vision due to secondary glaucoma. None of the eyes developed immunologic rejection. The PKP group showed a tendency of faster recovery in BCVA than the DLKP group, but the difference was not statistically significant. Contrast visual acuity, glare test, and corneal topography did not show significant differences between the two groups. The intraocular pressure was significantly higher at 12 months in the PKP group (P =.004), but not in the DLKP group (P =.41) compared with preoperative values. While the PKP group showed progressive decrease in endothelial density over 24 months, this was not observed in the DLKP group after surgery. Difference in endothelial density at 24 months reached statistical significance (P =.04). CONCLUSIONS: We found that DLKP was superior to PKP in its safety such as continuous decreases of endothelium or increases in intraocular pressure. However, endothelial damage can also occur in DLKP, especially in cases of intraoperative Descemet membrane rupture. With the development of easier surgical techniques, DLKP may be a first choice of keratoplasty in most eyes without endothelial abnormalities.

Adult↗