Biomedical subjects
Mitchell H Friedlaender
Publications and source records attributed to Mitchell H Friedlaender.
Ultraviolet radiation and the external eye.
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Objective measurement of allergic reactions in the eye.
PURPOSE OF REVIEW: Conjunctival allergen challenge has become a useful model of human ocular allergy and an accepted method for studying the effects of topical antiinflammatory medications. Conjunctival allergen challenge reactions are typically evaluated in a subjective fashion. Erythema and edema are graded by observation, using a 0 to 4 scale. Itching is graded on a 0 to 4 scale by questioning the subject. We have reviewed the recent literature on conjunctival allergen challenge, including recently developed methods aimed at objective assessment of ocular allergic reactions, such as the erythema, edema, sensation, or EES, method. RECENT FINDINGS: Conjunctival erythema can be measured objectively using a spectroradiometer, or colorimeter, a device which measures the chromaticity of reflected light, and provides the x, or u', and y, or v', coordinates of any color. Edema of the eyelids and conjunctiva can be measured using a fractional millimeter reticule in the eyepiece of a slit lamp microscope. Ocular surface sensation can be evaluated using the aesthesiometer of Cochet and Bonnet, or by using a 'sensation index', a measurement that takes into account the intensity and duration of itching. SUMMARY: CAC reactions can be measured objectively using the erythema, edema, sensation method, as well as subjectively by observation and questioning.
Conjunctival provocation testing: overview of recent clinical trials in ocular allergy.
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Conjunctival provocation testing: overview of recent clinical trials in ocular allergy.
PURPOSE OF REVIEW: The conjunctival provocation test is a human model of ocular allergy that has been used to study the ocular response to allergenic stimuli and to evaluate antiallergic therapy. The review will discuss recent studies using the conjunctival provocation test and other models of ocular allergy, and evaluate the relative merits of different models. RECENT FINDINGS: The conjunctival provocation test has allowed investigators to recruit large numbers of allergic individuals who, although asymptomatic, can be challenged with the conjunctival administration of allergen. Observations of the eye can be made before and after challenge, and cells and mediators may be sampled from the ocular surface. In addition, the effectiveness of antiallergic therapy can be evaluated, usually by pretreating the two eyes with different forms or doses of drug. SUMMARY: Considerable useful information has been gained about the ocular allergic response and drug efficacy using the conjunctival provocation test and naturally occurring seasonal allergic conjunctivitis.