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Biomedical subjects

Mitchell W Larsen

Publications and source records attributed to Mitchell W Larsen.

4 recordsLinked to original sources
PubMed2006

Surgical management of anterior cruciate ligament injuries in patients with open physes.

Because of the increasing number of skeletally immature athletes who compete in highly demanding sports, more children than previously are sustaining anterior cruciate ligament injuries. Treatment and patient compliance with treatment recommendations are problematic. Pediatric issues include those specific to evaluation, projected growth, and surgery. Strict activity modification can protect the knee from further injury and delay surgery, sometimes until maturity. Surgical options include physeal-sparing, partial transphyseal, and complete transphyseal procedures. Surgical procedures are demanding because typical drilling and fixation techniques can affect the physis and possibly lead to growth disturbances. A wide range of growth disturbances has been reported; these must be understood to perfect surgical technique and avoid potential growth concerns. Surgical challenges, options regarding delayed surgery, and possible outcomes all need to be clearly communicated to the patient and parents.

Anterior Cruciate Ligament↗
PubMed2005

Examination of posterolateral corner injuries.

Physical examination of patients with a suspected posterolateral corner injury must be comprehensive. Mechanical alignment, gait, and any hyperextension or varus thrust should all be evaluated. The status of all ligaments of the knee also must be thoroughly assessed. Detecting the presence or absence of a PCL can be difficult but is essential (Table). The dial test is easy to perform and is the most standard and accepted test to assess and follow posterolateral rotatory instability of the knee.

Humans↗
PubMed2005

Fixation of osteochondritis dissecans lesions using poly(l-lactic acid)/ poly(glycolic acid) copolymer bioabsorbable screws.

BACKGROUND: Many osteochondritis dissecans lesion fixation techniques are effective. A new absorbable copolymer screw may be suitable for this application. PURPOSE: To characterize the mechanical and in vitro absorption properties of a copolymer fixation screw and determine the clinical efficacy of using the screw to fix osteochondritis dissecans lesions. STUDY DESIGN: Case series and laboratory study; Level of evidence, 4. METHODS: Seven patients diagnosed with unstable, partially open osteochondritis dissecans lesions were treated with debridement of the bed and fixation with 2.5-mm diameter screws made of LactoSorb copolymer; the patients were nonweightbearing for 6 weeks. Clinical and radiographic follow-up was for 25 to 37 months. Biomechanical testing was performed in synthetic bone over a 12-week period on buffer-incubated specimens. RESULTS: Six of the 7 osteochondritis dissecans lesions healed clinically and radiographically; the osteochondritis dissecans fragment was removed from the seventh patient (unhealed). No symptoms indicative of an inflammatory reaction related to the presence of the absorbable screws, including recurrent effusion, warmth, or erythema, were noted. In the in vitro testing, the initial average peak pull-out and shear loads were 20.1 kg and 22.3 kg, respectively, with little strength remaining at 12 weeks. CONCLUSIONS: In general, the 2.5-mm-diameter LactoSorb copolymer screws provided adequate stability for healing of osteochondritis dissecans lesions and degraded without an inflammatory response by the body.

Absorption↗