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Mitsuo Takeda

Publications and source records attributed to Mitsuo Takeda.

At least 19 recordsLinked to original sources
PubMed2006

Two-wavelength Talbot effect and its application for three-dimensional step-height measurement.

The phenomenon of Talbot self-image shift by changing the wavelength of the illuminating light is described and demonstrated experimentally. A periodic grating is illuminated by light with wavelengths lambda1 and lambda2 generated by two lasers, and the Talbot self-images are recorded along the longitudinal direction at individual wavelengths. The Talbot self-image shift due to the change in the wavelength of light is implemented for the measurement of the three-dimensional step height of a large discontinuous object without any phase ambiguity problem. Fourier-transform fringe analysis was used to determine the maximum contrast of the high-visibility bands for the measurement of the step height of the object. The main advantages of the proposed system are nonmechanical scanning, high stability because of its common path geometry, compactness, and a wide range of measurement as compared to interferometric three- dimensional profilers.

Journal Article↗
PubMed2006

Linear and angular coherence momenta in the classical second-order coherence theory of vector electromagnetic fields.

A new concept of vector and tensor densities is introduced into the general coherence theory of vector electromagnetic fields that is based on energy and energy-flow coherence tensors. Related coherence conservation laws are presented in the form of continuity equations that provide new insights into the propagation of second-order correlation tensors associated with stationary random classical electromagnetic fields.

Journal Article↗
PubMed2006

Coherence current, coherence vortex, and the conservation law of coherence.

Introducing scalar and vector densities for a mutual coherence function, we present a new conservation law for optical coherence of scalar wave fields in the form of a continuity equation. This coherence conservation law provides new insights into topological phenomena for the complex coherence function. Some properties related to the newly introduced coherence vector density, such as a circulating coherence current associated with a coherence vortex, are investigated both theoretically and experimentally for the first time.

Journal Article↗
PubMed2006

Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis.

Nicorandil has been shown to inhibit myocyte apoptosis by opening of mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels and nitrate-like effect against oxidative stress. However, the detailed mechanism of nicorandil-mediated cardioprotection under hypoxic conditions remains to be largely unknown. The present study examined whether nicorandil can inhibit apoptosis via regulation of Bcl-2 family proteins in hypoxic myocytes. Neonatal rat cardiac myocytes were exposed to hypoxia for 7 hours. Hypoxia-induced myocyte apoptosis (13.9+/-0.9%) under glucose-rich conditions. Myocyte apoptosis was accompanied by loss of mitochondrial membrane potential (Deltapsi(m)), cytochrome c release from mitochondria into cytosol, and activation of caspase-3. Hypoxia also significantly increased Bax and decreased Bcl-2 mRNA and protein expression, thereby increasing Bax/Bcl-2 ratio. Nicorandil 100 micromol/l significantly decreased the percentage of apoptotic myocytes (7.2+/-0.5%) by inhibiting loss of Deltapsi(m) and translocation of cytochrome c. These effects of nicorandil were partially but significantly inhibited by cotreatment of either 500 micromol/l 5-hydroxydecanoate, a selective mitoK(ATP) channel antagonist, or 10 micromol/l 1H-[1,2,4]oxidazolo[4,3-a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase. Moreover, nicorandil significantly inhibited the hypoxia-induced changes in Bax and Bcl-2 expression, and concomitant increased Bax and decreased Bcl-2 immunoreactivity in mitochondria. These effects of nicorandil in Bax and Bcl-2 expression were significantly blunted by cotreatment of ODQ and 5-HD, respectively. Cotreatment of KT5823, an inhibitor of protein kinase G, significantly blocked the effect of nicorandil on Bax expression and 8-bromo-cyclic guanosine 3',5' monophosphate (8-bromo-cGMP), a cGMP analog, mimicked the effect of nicorandil on Bax expression. The present study demonstrates that nicorandil regulates Bcl-2 family proteins via opening of mitoK(ATP) channels and nitric oxide-cGMP signaling and inhibits hypoxia-induced mitochondrial death pathway.

Animals↗
PubMed2006

Experimental study of coherence vortices: local properties of phase singularities in a spatial coherence function.

By controlling the irradiance of an extended quasimonochromatic, spatially incoherent source, an optical field is generated that exhibits spatial coherence with phase singularities, called coherence vortices. A simple optical geometry for direct visualization of coherence vortices is proposed, and the local properties and the spatial evolution of coherence vortex are experimentally investigated. To our knowledge, this is the first direct and quantitative experimental measurement of a generic coherence vortex.

Journal Article↗
PubMed2006

Complex amplitude correlations of dynamic laser speckle in complex ABCD optical systems.

Within the framework of complex ABCD-matrix theory, exact theoretical expressions are derived for the space-time-lagged cross-covariance functions of the fields valid for arbitrary (complex) ABCD-optical systems, i.e., systems that include Gaussian-shaped apertures and partially developed speckle. Specifically, we show and discuss the results for the three generic systems, i.e., free-space propagation, Fourier transform configuration, and imaging. To cope with various surface structures of varying rms surface heights, we apply two models in addition to employing the usual model for surfaces giving rise to fully developed speckle. The theoretical results found for free-space propagation are supported by interferometrically obtained data.

Journal Article↗
PubMed2005

Common-path achromatic interferometer-coronagraph: nulling of polychromatic light.

A three-dimensional common-path interferometer is proposed, which can achromatically null out an on-axis source while it maintains the detectability of an off-axis source. A geometric phase in the three-dimensional interferometer introduces an achromatic pi-phase shift to the light from the on-axis source, such that destructive interference nulls out the axial light at one of the ports of the interferometer. Light from the off-axis source, which is exempt from the pi-phase shift, comes out from both ports with equal intensity. The common-path scheme makes the system highly immune to environmental disturbances.

Journal Article↗
PubMed2005

Pseudophase information from the complex analytic signal of speckle fields and its applications. Part I: microdisplacement observation based on phase-only correlation in the signal domain.

As an alternative to the intensity correlation used in conventional speckle metrology, we propose a new technique for displacement observation that is based on spatial-signal-domain phase-only correlation and that makes use of the pseudophase of the complex analytic signal generated from a Hilbert-filtered speckle pattern. Experimental results are presented that demonstrate the validity and the advantage of the proposed signal-domain phase-only correlation technique over both the conventional intensity correlation technique and the spatial-frequency-domain phase-only correlation technique.

Journal Article↗
PubMed2005

Pseudophase information from the complex analytic signal of speckle fields and its applications. Part II: statistical properties of the analytic signal of a white-light speckle pattern applied to the microdisplacement measurement.

To provide a theoretical background for the superiority of the signal-domain phase-only correlation (SDPOC) technique proposed here for microdisplacement measurement, we study the first- and the second-order statistical properties of the complex amplitude of an analytic signal of a white-light speckle pattern, under the assumption of a Gaussian random process, and give a formula for the autocorrelation function of the pseudophase associated with the complex analytic signal. Based on these results, we show mathematically that SDPOC has a performance advantage over conventional intensity-based correlation techniques.

Journal Article↗
PubMed2005

Experimental investigation of local properties and statistics of optical vortices in random wave fields.

We present the first direct experimental evidence of the local properties of optical vortices in a random laser speckle field. We have observed the Berry anisotropy ellipse describing the anisotropic squeezing of phase lines close to vortex cores and quantitatively verified the Dennis angular momentum rule for its phase. Some statistics associated with vortices, such as density, anisotropy ellipse eccentricity, and its relation to zero crossings of real and imaginary parts of the random field, are also investigated by experiments.

Journal Article↗
PubMed2005

Propagation analysis of the Laguerre-Gaussian beam with astigmatism.

The entire range of transformations that a Laguerre-Gaussian (LG) beam with astigmatism can go through in free space is clarified. The transformations are governed by the relative phase between the astigmatic Hermite-Gaussian components. Formulas describing the behavior of this relative phase are obtained and used to classify and map the transformation patterns to initial beam parameters. The difference between an LG beam and a phase singular beam generated by a hologram under astigmatic conditions is also investigated.

Journal Article↗
PubMed2004

Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways.

BACKGROUND: Aldosterone has recently attracted considerable attention for its involvement in the pathophysiology of heart failure, in which apoptotic cell loss plays a critical role. This study examined whether aldosterone directly induces myocyte apoptosis via its specific receptors. METHODS AND RESULTS: Neonatal rat cardiac myocytes were exposed to aldosterone (10(-8) to 10(-5) mol/L). Nuclear staining with Hoechst 33258 showed that aldosterone induced myocyte apoptosis in a dose- and time-dependent fashion. Treatment of myocytes with 10(-5) mol/L aldosterone significantly increased the percentage of apoptosis (15.5+/-1.4%) compared with serum-deprived control (7.3+/-0.6%). Radio ligand binding assay revealed the existence of plasma membrane receptor with high affinity (K(d), 0.2 nmol/L) for aldosterone in cardiac myocytes but not in fibroblasts. Aldosterone rapidly (approximately 30 seconds) mobilized [Ca2+]i that was blocked by neomycin. Aldosterone induced dephosphorylation of the proapoptotic protein Bad, enhancement of mitochondrial permeability transition, decrease in mitochondrial membrane potential, and release of cytochrome c from the mitochondria into the cytosol with concomitant activation of caspase-3. These effects of aldosterone were inhibited by concurrent treatment with either an L-type Ca2+ channel antagonist, nifedipine, or inhibitors for the Ca2+-dependent phosphatase calcineurin, cyclosporin A and FK506. CONCLUSIONS: The present study demonstrates for the first time that the specific plasma membrane receptor (coupled with phospholipase C) for aldosterone is present on cardiac myocytes and that aldosterone accelerates the mitochondrial apoptotic pathway through activation of calcineurin and dephosphorylation of Bad, suggesting that the proapoptotic action of aldosterone may directly contribute to the progression of heart failure.

Aldosterone↗
PubMed2004

A case of deep venous thrombosis with a double inferior vena cava effectively treated by suprarenal filter implantation.

Embryogenesis of the inferior vena cava (IVC) is a complex process involving the formation and regression of several anastomoses, thus, various anomalies may occur. We report a case of deep venous thrombosis (DVT) accompanied by a double inferior vena cava (DIVC). A 76-year-old-man was admitted because of right leg edema and pain. Venography revealed two IVC and massive venous thrombus. To avoid massive pulmonary embolism (PE), it was necessary to block both the right and the left IVC. However, the right IVC was too small to implant the filter, so we placed a temporary IVC filter (Antheor filter) in the suprarenal portion of the IVC, after the confluence of the two IVC, and started thrombolytic and anticoagulant therapy. Venography, performed 6 days after filter implantation, showed a considerable amount of remaining thrombus. We replaced the Antheor filter with a Gunther retrievable filter because the former has a catheter and is not suited for long-term use, whereas the latter can be used permanently. Two weeks after filter exchange, thrombus had decreased but remained. We therefore did not remove the Gunther filter. The patient's symptoms gradually improved in response to anticoagulant therapy, and he was discharged with no complications. The present case illustrates the importance of a correct understanding of anatomy and demonstrates the effectiveness of using a suprarenal IVC filter in DVT.

Aged↗
PubMed2003

High-resolution two-dimensional angle measurement technique based on fringe analysis.

A novel angle-measurement technique based on fringe analysis for phase-measuring profilometry is proposed. A two-dimensional (2-D) angle between two mirror surfaces is determined by least-squares fitting of a plane to the 2-D distribution of the phase difference introduced by the 2-D tilt angle. To evaluate the performance of the proposed technique, numerical simulations that use the Fourier-transform technique and the phase-shift technique for fringe analysis were performed, and the results are compared. A 2-D angle-measurement interferometer based on a Mirau interference microscope was developed that demonstrated the validity of the proposed principle. It is shown by simulation and experiment that the proposed 2-D angle-measurement technique can achieve both a wide measurement range and a high angular resolution simultaneously.

Journal Article↗
PubMed2003

Nitric oxide-cGMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts.

The mechanisms by which endotoxemia causes cardiac depression have not been fully elucidated. The present study examined the involvement of nitric oxide (NO) in this pathology. Rats were infused with lipopolysaccharide (LPS) or saline, and the plasma and myocardial NO(2)(-) and NO(3)(-) (NOx) concentrations were measured before or 3, 6, and 24 h after treatment. The hearts were then immediately isolated and mounted in a Langendorff apparatus, and left ventricular developed pressure (LVDP) was determined before biochemical analysis of the myocardium. LPS injection effected the expression of inducible NO synthase (iNOS) in the myocardium, a marked increase in plasma and myocardial NOx levels, and a significant decline in LVDP compared with saline controls. The LPS-induced NO production and concomitant cardiac depression were most pronounced 6 h after LPS injection and were accompanied by a significant increase in myocardial cGMP content. Myocardial ATP levels were not significantly altered after LPS injection. Significant negative correlation was observed between LVDP and myocardial cGMP content, as well as between LVDP and plasma NOx levels. Aminoguanidine, an inhibitor of iNOS, significantly attenuated the LPS-induced NOx production and contractile dysfunction. Furthermore, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, an inhibitor of soluble guanylate cyclase, significantly decreased myocardial cGMP content and attenuated the contractile depression, although aminoguanidine or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one was not able to completely reverse myocardial dysfunction. Our data suggest that endotoxin-induced contractile dysfunction in rat hearts is associated with NO production by myocardial iNOS and a concomitant increase in myocardial cGMP.

Animals↗
PubMed2003

The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts.

OBJECTIVE: Nitric oxide (NO) is known to act as a mediator of tissue injury as well as being a potent endogenous vasodilator. The functional and metabolic effects of NO on ischemia-reperfusion injury are still controversial. The aim of this study was to clarify the relationship between the degree of NO synthase (NOS) inhibition and the effects on ischemia-reperfusion injury. METHODS AND RESULTS: Langendorff-perfused rat hearts were subjected to 30 minutes of global ischemia followed by 30 minutes of reperfusion. The recovery of left ventricular developed pressure (LVDP), creatine kinase (CK) release, and myocardial high energy phosphates were measured in hearts perfused with or without NOS inhibitors, L-N(G)-monomethyl arginine (L-NMMA) or N(G)nitro-L-arginine methylester (L-NAME). NOS inhibitors exerted different effects on the recovery of LVDP and CK release depending on the concentration. The low dose of L-NMMA improved the recovery of LVDP, decreased the CK release during reperfusion, and preserved the myocardial adenosine triphosphate content after reperfusion. In contrast, the high dose of L-NMMA had adverse effects. L-NMMA reduced NO release in coronary effluent in a dose-dependent fashion. Both effects of L-NMMA were abolished by excessive co-administration of L-arginine and the same doses of D-N(G)-monomethyl arginine (D-NMMA) showed no effect on ischemia-reperfusion injury. Therefore, both effects were due to NOS inhibition. In addition, L-NMMA suppressed the myocardial malondialdehyde accumulation, an indicator of oxidative stress, which might be attributed to the beneficial effects by partial NOS inhibition. On the other hand, the high dose L-NMMA significantly decreased coronary fl ow during aerobic perfusion and reperfusion. Therefore, it is conceivable that the vasoactive NOS inhibition contributes to the harmful effects, which might exceed the beneficial effects due to a decrease in oxidative stress. CONCLUSION: The present results showed that NO inhibitors had dual effects on mechanical function and energy metabolism depending on the concentration. Non-vasoactive inhibition of NOS had beneficial effects due to the suppression of oxidative injury. However, strong vasoactive inhibition of NOS exacerbated the ischemia-reperfusion injury.

Adenine Nucleotides↗
PubMed2003

Spectral interference Mirau microscope with an acousto-optic tunable filter for three-dimensional surface profilometry.

A nonmechanical scanning Mirau-type spectral interference microscope has been developed for the measurement of three-dimensional surface profiles of discontinuous objects. An acousto-optic tunable filter (AOTF) is used as a high-resolution spectral filter, which scans the optical frequency of the broadband light emitted from a superluminescent diode. To generate spectral fringes that make full use of the limited coherence length of the filtered light we unbalanced the Mirau interferometric system by positioning the reference mirror nearly halfway between the top and the bottom of the step height. When the frequency of the broadband light source is scanned by an AOTF, the interference fringes move in opposite directions on the top and the bottom of the object. To uniquely determine the sign of the fringe movement over the large area of the object, we developed a three-dimensional Fourier-transform technique, and from the detected sign of the fringe movement and phase information, we determined the three-dimensional step height. Experimental results of the measurement of 100-microm step height are presented. The main advantages of the proposed system are that it provides nonmechanical scanning and a large measurement range without ambiguity in the sign of the phase.

Journal Article↗