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Biomedical subjects

Mohamed Tahar Yacoubi

Publications and source records attributed to Mohamed Tahar Yacoubi.

5 recordsLinked to original sources

[Gastrointestinal stromal tumors. Current data].

GIST anatomical concept, recently elucidate, they are characterized by the expression of the protooncogene C Kit The diagnosis is relatively easy but prognosis evaluation is not usually possible. The treatment is based on the surgical resection. The rewardable clinical response of tumors that express C-Kit to treatment with the tyrosine kinase inhibitor STI 571 is a triumph of molecular pharmacology.

Antineoplastic Agents↗

[Renal oncocytoma: report of 5 cases].

Renal oncocytoma is a rare, benign tumour, which is rarely diagnosed preoperatively. The authors report 5 cases of renal oncocytoma operated over a 10-year period. Based on a review of the literature, the various complementary investigations allowing a preoperative diagnosis and the indications for conservative surgery are discussed and analysed.

Adenoma, Oxyphilic↗

[Surgical treatment of penile-scrotal elephantiasis].

Penoscrotal elephantiasis is a rare disease outside of filariasis endemic regions. The authors report a case of primary penoscrotal elephantiasis treated by complete surgical resection of the pathological tissue and penoscrotal reconstruction, with a good functional and cosmetic result. The complementary investigations indicated and the various treatment options are analysed in the light of a review of the literature.

Adult↗

[Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].

The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.

Adolescent↗