PubMed Health⌕ Search

Biomedical subjects

Moishe Liberman

Publications and source records attributed to Moishe Liberman.

At least 19 recordsLinked to original sources

Unification of the revised trauma score.

BACKGROUND: The Revised Trauma Score (RTS) calculated with Major Outcome Trauma Study weights (MTOS-RTS) is currently the standard physiologic severity score in trauma research and quality control. It is often confused with the Triage-RTS (T-RTS), a version that is easier to calculate but only intended for clinical triage. OBJECTIVES: To compare the accuracy of the MTOS-RTS to the RTS calculated with weights derived from the study population (POP-RTS) and the T-RTS, for predicting mortality in a trauma population. METHODS: The study population consists of 22,388 patients, drawn from the trauma registries of three Level I trauma centers. The predictive accuracy of the MTOS-RTS, POP-RTS, and the T-RTS were compared using measures of discrimination and model fit from logistic regression models. RESULTS: The MTOS-RTS, the POP-RTS, and the T-RTS had the same discrimination (Area under the Receiver Operating Curve [AUC] = 0.841). The POP-RTS and the T-RTS had a slightly better model fit than the MTOS-RTS (AIC = 8010, 8010, and 8067, respectively). The T-RTS had equal discrimination and equal or better model fit than the MTOS-RTS in the whole sample, in each of the three trauma centers and in the population of patients with severe head trauma. The T-RTS was also equivalent to the POP-RTS in all of these population sub-groups. CONCLUSIONS: The T-RTS could replace the MTOS-RTS as the standard physiologic severity score for trauma outcome prediction. The advantages of using the T-RTS over the MTOS-RTS are ease of calculation, the need for only one measure for triage and mortality prediction purposes and universal adaptation to a broad range of trauma populations.

Aged↗

Two worst injuries in different body regions are associated with higher mortality than two worst injuries in the same body region.

BACKGROUND: The Injury Severity Score (ISS) accounts for only one injury in each body region. The New Injury Severity Score (NISS) considers all injuries in a body region. Despite a big difference between the two scores in patients with multiple injuries, the NISS does not offer significant improvement in mortality prediction. This paper hypothesizes that two injuries in different body regions are associated with higher mortality than two injuries in the same body region, independently of injury severity. METHODS: The population consisted of 15,200 patients with two or more injuries from the Quebec Trauma Registry, Canada, abstracted between 1998 and 2004. The two worst injuries were considered. Logistic regression analysis was used to assess the mortality odds ratio of having two worst injuries in different body regions (DR) compared with two worst injuries in the same body region (SR), while adjusting for the severity and the body region of the two worst injuries and age. RESULTS: A total of 5,869 patients (49%) had their worst injuries in DR. DR patients had 75% higher risk of mortality than SR patients (odds ratio = 1.75, 95% confidence interval = 1.42-2.15). CONCLUSION: After accounting for differing injury severity, patients with their two worst injuries in different body regions have higher mortality than those with their two worst injuries in the same region. Results suggest that the observed effect is not due to a foible in the Abbreviated Injury Scale system but rather to physiologic, clinical, or organizational elements. The results of this study should be considered in the development of future injury severity instruments and may have implications for the care of patients with multiple injuries.

Aged↗

Statistical validation of the Revised Trauma Score.

BACKGROUND: To validate the accuracy of the Revised Trauma Score (RTS) and its components for predicting in-hospital mortality. METHODS: Analyses were based on 22,388 patients from the trauma registries of three urban Level I trauma centers in the province of Quebec, Canada. The accuracy of RTS coded variables for the Glasgow Coma Score (GCSc), Systolic Blood Pressure (SBPc), and Respiratory Rate (RRc) for predicting mortality was evaluated in logistic regression models with measures of discrimination and model fit and compared with Fractional Polynomial (FP) transformations of each component. RESULTS: RTS coded variables were associated with sparse data distributions and did not accurately represent the relation of GCS, SBP, and RR to mortality. FP models were always associated with significantly better discrimination (all p < 0.00001) and model fit. Survival probability estimates generated by the model with FP transformations were significantly different to those generated by the model with RTS-coded variables. CONCLUSIONS: The RTS in its present form does not accurately describe the relation of GCS, SBP, and RR to mortality. FP transformation would improve the accuracy of predicted survival probabilities used for performance evaluation and may improve control of confounding caused by of physiologic severity case mix in trauma research.

Adolescent↗

Functional status and quality of life in survivors of injury treated at tertiary trauma centers: what are we neglecting?

BACKGROUND: The purpose of this study was to describe the functional status and quality of life (QOL) of patients at 12 months after injury. METHODS: Retrospective study consisting of patients treated at three tertiary trauma centers for injuries. Functional capacity (FC) was measured using the Sickness Impact Profile and QOL was measured using the Medical Outcomes Study Short Form (MOS SF-36) at approximately 12 months after the date of injury. RESULTS: There were 144 patients that fulfilled the study inclusion and exclusion criteria. The mean duration of follow-up was 1.3 years, with a range of 0.8 to 1.5 years. Age and gender were not associated with the FC or QOL. The mean(standard deviation) Injury Severity Score (ISS) was 18.9(9.4), whereas ISS category distribution was 1 to 11 (22.9%), 12 to 24 (50.0%), and 25 to 49 (27.1%). Patients with an ISS of 25 to 49 had significantly worse physical (p = 0.008) and total (p = 0.023) Sickness Impact Profile scores and had more physical functioning (p = 0.096), emotional role functioning (p = 0.080), and energy (p = 0.017) impairments when compared with those with an ISS less than 24. Patients injured in motor vehicle collisions had significantly impaired psychosocial function (p = 0.031), whereas those injured in falls had reduced quality of life scores for physical function (p = 0.089), physical role (p = 0.066), and mental health (p = 0.081). CONCLUSION: Patients who survive injuries experience residual impairments in FC and QOL for as long as 1 year after injury. Changes to the long-term management of these patients should be considered.

Activities of Daily Living↗

Delays to surgery in non-small-cell lung cancer.

BACKGROUND: In Canada, waiting times for referral and surgery exist for both benign and malignant disease. We attempted to evaluate the length of various waiting times for surgery as well as their association with surgical stage in patients with non-small-cell lung cancer (NSCLC). METHODS: This observational study consisted of a retrospective review of data for all patients who underwent an operation with the intent to cure NSCLC between Jan. 1, 1993, and Dec. 31, 2002, at the Montreal General Hospital, McGill University Health Centre, Montréal, Que. Time intervals between multiple preoperative points and surgery were calculated. The patients were then linked via universal health care insurance numbers with data from the centralized provincial inclusive health care database. This allowed the calculation of the precise interval between the patients' first contact with a physician for symptoms related to their malignancy and surgery. Mean time intervals were then compared with surgical stage. RESULTS: We found adequate data for time interval analysis over 10 years for 256 patients who had undergone surgery with intent to cure. The distribution of patients by TNM stage was as follows: stage I, 144 patients (56.3%); stage II, 47 patients (18.4%); stage III, 41 patients (16.0%); and stage IV, 24 patients (9.4%). Mean and median time intervals between initial contact with physician or first onset of symptoms relating to lung cancer and surgery were 208 (standard deviation [SD] 313) days and 109 days, respectively. Mean and median time intervals between initial contact with the thoracic surgeon and surgery were 104 (SD 99) days and 82 days, respectively. No detrimental effect was observed between time to surgery and surgical stage in patients with NSCLC. CONCLUSIONS: Excessive preoperative waiting times before attempts at curative surgical resection for NSCLC exist in our centre. These intervals are exceptionally long, multifactorial and cause for concern.

Aged↗

The Injury Severity Score or the New Injury Severity Score for predicting intensive care unit admission and hospital length of stay?

OBJECTIVES: To compare the New Injury Severity Score (NISS) and the Injury Severity Score (ISS) as predictors of intensive care unit (ICU) admission and hospital length of stay (LOS) in an urban North American trauma population and in a subset of patients with head injuries. METHODS: The study population consisted of 23,909 patients from three urban level I trauma centres in the province of Quebec, Canada. The predictive accuracies of the NISS and the ISS were compared using Receiver Operator Characteristic (ROC) curves and Hosmer-Lemeshow (H-L) statistics for the logistic regression model of ICU admission and using r2 for the linear regression model of LOS. RESULTS: A total of 7660 (32%) patients were admitted to the ICU. Mean LOS was 8.2+/-2.5 days. In the whole sample, the NISS presented equivalent discrimination (area under ROC curve: NISS = 0.839 versus ISS = 0.843, p = 0.08) but better calibration (H-L statistic: 309 versus 611) for predicting ICU admission. In the subgroup patients with moderate to serious head injuries, the NISS was a better predictor of ICU admission in terms of both discrimination (area under ROC curve: NISS = 0.771 versus ISS = 0.747, p < 0.00001) and calibration (H-L statistic: 12 versus 21). The NISS explained more variation in LOS than the ISS for the whole sample (r2 = 0.254 versus 0.249, p = 0.0008) and in the sub-population with moderate to severe head injuries (r2 = 0.281 versus 0.263, p = 0.0002). CONCLUSIONS: The NISS is a better choice for case mix control in trauma research than the ISS for predicting ICU admission and LOS, particularly among patients with moderate to severe head injuries.

Adolescent↗

Clinical evaluation of the spine in the intoxicated blunt trauma patient.

The objective of the current study was to evaluate the accuracy of the clinical examination of the spine following blunt trauma in intoxicated patients. Methods included a retrospective review of all cases of blunt trauma presenting to an urban level I trauma centre over 1 year. Data was analysed separately for the clinical examination of the cervical spine (CS) and for the thoracic and lumbar spine (T + LS). Two hundred and sixteen cases of blunt trauma secondary to MVC (n = 143) or falls (n = 73) were retained for analysis. In intoxicated patients, sensitivities and specificities for CS tenderness were 60.0 and 64.3% (radiological abnormality) and 100 and 68.6% (operative stabilization), respectively. With respect to the T + LS in intoxicated patients; sensitivities and specificities for T + LS tenderness and radiological abnormality were 80.0 and 71.4% and for the ability of the clinical examination to pick up unstable T + LS fractures requiring operative stabilization 100 and 72.0%, respectively. Intoxicated blunt trauma patients may be able to have spine fractures requiring operative stabilization excluded using physical examination of the spine at presentation to the trauma center.

Alcoholic Intoxication↗

Ten-year surgical experience with nontraumatic pericardial effusions: a comparison between the subxyphoid and transthoracic approaches to pericardial window.

HYPOTHESIS: The approach to pericardial window in patients with nontraumatic pericardial effusion impacts outcome. DESIGN: Retrospective review and comparison of all cases of pericardial window performed over 10 years. Follow-up was to patient death. SETTING: Three hospitals performing cardiothoracic surgery at a single university. PATIENTS: All patients in whom pericardial window was performed for nontraumatic pericardial effusion. MAIN OUTCOME MEASURES: Outcomes associated with the subxyphoid approach to pericardial window were compared with those associated with the transthoracic approach. The primary outcome was postsurgical recurrence of pericardial effusion. Secondary outcomes included operative time, intraoperative and postoperative complications, in-hospital mortality, hospital and intensive care unit lengths of stay, and days between surgery and death. RESULTS: Over 10 years, there were 342 patients with procedural codes for pericardial window in the medical record databases of 3 hospitals performing cardiothoracic surgery at 1 university center. One hundred fifty-one patients were excluded because the operation was performed for trauma, postoperative tamponade, or pericardial biopsy without effusion. The results are, therefore, based on the remaining 191 procedures. The subxyphoid approach was used in 78 patients, and the transthoracic approach in 113 patients. Patients were well matched for age (P = .31), sex (P = .05), preoperative tamponade (P = .08), and comorbidities (P > .05). No differences were observed between the 2 approaches in terms of recurrence of effusion, operative time, overall intraoperative or postoperative complications, and hospital or intensive care unit lengths of stay. In-hospital mortality was significantly greater in the subxyphoid group (27 of 78 vs 18 of 113 patients; P = .003). CONCLUSIONS: Over 10 years, there were 191 pericardial windows performed for nontraumatic pericardial effusions. The subxyphoid and transthoracic approaches were well tolerated by patients, required short operative times, and resulted in similar rates of overall postoperative complications and intensive care unit and hospital lengths of stay. Recurrence rates were low with both procedures.

Aged↗

The association between trauma system and trauma center components and outcome in a mature regionalized trauma system.

BACKGROUND: Regionalized trauma systems have been shown repeatedly to improve the outcome of seriously injured patients. However, we do not have data regarding which components of these systems have the most impact on outcome and to what degree. The objective of this study was to understand the association between various components that make up a trauma system and outcome. METHODS: Surveys were administered to trauma directors at 59 hospitals in the province of Quebec, Canada. Data from the surveys were then linked with specific outcome variables obtained from a regionalized trauma database. Specific outcomes were assigned to trauma system- and in-hospital-based components after controlling for injury severity. RESULTS: Over 4.8 years, 72,073 patients met inclusion criteria. Components found to affect survival after risk adjustment were prehospital notification (OR, 0.61; 95% CI, 0.39-0.94) and the presence of a performance improvement program in that hospital (OR, 0.44; 95% CI, 0.20-0.94). Increased patient volume was associated with a reduction in risk-adjusted mortality (OR, 0.98; 95% CI, 0.97-0.99). Tertiary trauma centers were also associated with a reduction in risk-adjusted mortality compared with both secondary and primary centers (OR, 0.68; 95% CI, 0.48-0.99). CONCLUSIONS: Improvements in outcome in a regionalized trauma system are secondary to a combination of elements, as well as to the interplay of these elements on each other. Prehospital notification protocols and performance improvement programs appear to be most associated with decreased risk-adjusted odds of death.

Emergency Medical Service Communication Systems↗

Surgery residents and attending surgeons have different perceptions of feedback.

Feedback plays an important role in Postgraduate Medical Education and is indispensable in surgical training. Improvement in operating skills, for example, requires constant feedback between teacher and learner to promote reflection on performance. Prior to providing workshops on giving effective feedback, the goal of this study was to assess the perceptions of attending surgeons and residents on feedback practices in our program. We show a startling disparity in perceptions of feedback frequency and skills. The results were used in planning a Workshop on Giving Feedback for our faculty. The effectiveness of this Workshop will be assessed at a later date by administering the same questionnaire.

Attitude of Health Personnel↗

A second injury in the same body region is associated with lower mortality than a second injury in a different body region.

HYPOTHESIS: A second injury in the same body region is associated with lower mortality than a second injury in a different body region, independently of injury severity and body region. METHODS: The population consisted of 15,200 patients with two or more injuries from level I trauma centers in Quebec. The mortality odds ratio of having a same-region second injury (SR) as opposed to a different-region second injury (DR) was assessed. RESULTS: Patients with a SR had 43% lower odds of mortality when compared to patients with a DR. CONCLUSION: A second injury in the same body region is associated with lower mortality than a second injury in a different body region.

Accidents, Traffic↗

Multiple imputation of the Glasgow Coma Score.

BACKGROUND: To investigate whether multiple imputation (MI) of missing Glasgow Coma Scale (GCS) values generates more accurate GCS frequency distributions and less biased parameter estimates in logistic regression models predicting mortality than the standard procedure of excluding observations with missing GCS values. METHODS: The study population consisted of 5,065 patients with complete GCS information from the trauma registry of a Level 1 trauma center. Missing GCS values were imposed on the data set, and the performance of MI (extrapolating missing GCS from a data prediction model) and of deleting all data observations with missing GCS (list-wise deletion) were evaluated. GCS and Trauma and Injury Severity Score (TRISS) frequency distributions and parameter estimates were compared with true values from the original data set. RESULTS: GCS and TRISS frequency values generated by MI were much more accurate than those generated by list-wise deletion. GCS and TRISS parameter estimates generated by MI all had acceptable bias and coverage rates when compared with true values. List-wise deletion provided biased parameter estimates for the GCS, the Revised Trauma Score, and the Injury Severity Score. CONCLUSION: MI is a valid solution to the problem of missing GCS data in trauma research. It allows the conservation of precious data observations and leads to unbiased estimates in consequent analyses. Analyses, which exclude observations with missing GCS data, provide biased results.

Biomedical Research↗

Large remnant 131I ablation as an alternative to completion/total thyroidectomy in the treatment of well-differentiated thyroid cancer.

BACKGROUND: An alternative to completion thyroidectomy for well-differentiated thyroid carcinoma is to ablate the remnant lobe with 131 I. The purpose of this study is to review our own experience with large remnant ablation. METHODS: A retrospective review of 169 patients with well-differentiated thyroid cancer treated at one institution over a 14-year period was undertaken. Seventy-one patients who underwent partial thyroidectomy (PT) followed by 131 I ablation were identified. This group was compared to 98 patients treated with total thyroidectomy (TT). RESULTS: Mean follow-up was 6.2 years for the 71 PT + 131 I versus 4.7 years for the 98 TT patients (P = .184). Recurrence occurred in 4 of 71 PT + I 131 patients (5.6%) versus 9 of 98 TT patients (9.2%) (P = .393). Other than a tendency for the size of the primary to be slightly larger and for the histology to be follicular carcinoma in the PT + 131 I patients, the 2 groups were nearly identical in age, gender, and other prognostic factors such as capsular invasion and metastases. CONCLUSIONS: Large-dose ablation with 131 I is a viable alternative to completion thyroidectomy. Recurrence rates over an average 6-year period are similar to TT. Long-term monitoring of these cohorts is required.

Adenocarcinoma↗

Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients.

OBJECTIVE: This study tested the hypothesis that weight-reduction (bariatric) surgery reduces long-term mortality in morbidly obese patients. BACKGROUND: Obesity is a significant cause of morbidity and mortality. The impact of surgically induced, long-term weight loss on this mortality is unknown. METHODS: We used an observational 2-cohort study. The treatment cohort (n = 1035) included patients having undergone bariatric surgery at the McGill University Health Centre between 1986 and 2002. The control group (n = 5746) included age- and gender-matched severely obese patients who had not undergone weight-reduction surgery identified from the Quebec provincial health insurance database. Subjects with medical conditions (other then morbid obesity) at cohort-inception into the study were excluded. The cohorts were followed for a maximum of 5 years from inception. RESULTS: The cohorts were well matched for age, gender, and duration of follow-up. Bariatric surgery resulted in significant reduction in mean percent excess weight loss (67.1%, P < 0.001). Bariatric surgery patients had significant risk reductions for developing cardiovascular, cancer, endocrine, infectious, psychiatric, and mental disorders compared with controls, with the exception of hematologic (no difference) and digestive diseases (increased rates in the bariatric cohort). The mortality rate in the bariatric surgery cohort was 0.68% compared with 6.17% in controls (relative risk 0.11, 95% confidence interval 0.04-0.27), which translates to a reduction in the relative risk of death by 89%. CONCLUSIONS: This study shows that weight-loss surgery significantly decreases overall mortality as well as the development of new health-related conditions in morbidly obese patients.

Adult↗

Implementation of a trauma care system: evolution through evaluation.

BACKGROUND: The regionalization of trauma services has been implemented in many health care systems and communities over the past 10 to 20 years. As these trauma systems mature and evolve, changes are made to improve the care and efficiency of the system. Trauma care regionalization was introduced in Quebec in 1993. This study looked at the evolution of trauma care in Quebec over the past 13 years, from the preregionalization era to the present. METHODS: A retrospective review scientifically evaluated a trauma system, the implementation of evidence-based changes, and the efficacy of these changes. RESULTS: Various changes have been made in the Quebec trauma system since the introduction of regionalization. These changes have led to an incremental decrease in mortality caused by severe trauma from 51.8% in 1992 to 8.6% in 2002. CONCLUSION: A trauma system is fluid and constantly evolving. Research and constant reevaluation are necessary for continuous evaluation of the system and improvement of its outcomes and efficiency.

Emergency Medical Services↗

The New Injury Severity Score: a more accurate predictor of in-hospital mortality than the Injury Severity Score.

OBJECTIVE: The purpose of this study was to determine whether the New Injury Severity Score (NISS) is a better predictor of mortality than the Injury Severity Score (ISS) in general and in subgroups according to age, penetrating trauma, and body region injured. METHODS: The study population consisted of 24,263 patients from three urban Level I trauma centers in the province of Quebec, Canada. Discrimination and calibration of NISS and ISS models were compared using receiver operator characteristic (ROC) curves and Hosmer-Lemeshow statistics. RESULTS: NISS showed better discrimination than ISS (area under the ROC curve = 0.827 vs. 0.819; p = 0.0006) and improved calibration (Hosmer-Leme-show = 62 vs. 112). The advantage of the NISS over the ISS was particularly evident among patients with head/neck injuries (area under the ROC curve = 0.819 vs. 0.784; p < 0.0001; Hosmer-Lemeshow = 59 vs. 350). CONCLUSION: The NISS is a more accurate predictor of in-hospital death than the ISS and should be chosen over the ISS for case-mix control in trauma research, especially in certain subpopulations such as head/neck-injured patients.

Adolescent↗

The impact of weight reduction surgery on health-care costs in morbidly obese patients.

BACKGROUND: The treatment of obesity and related comorbidities are significant financial burdens and sources of resource expenditure. This study was conducted in order to assess the impact of weight-reduction surgery on health-related costs. METHODS: This was an observational two-cohort study. The treatment cohort included patients having undergone weight-reduction (bariatric) surgery at the McGill University Health Centre (MUHC) between 1986 and 2002. The control group included age and gender matched obese patients who had not undergone weight-reduction surgery from the Quebec provincial health insurance database (RAMQ). The cohorts were followed for a maximum of 5 years from inception. The primary outcome measure was overall direct healthcare costs. Secondary outcomes included cost analysis by diagnostic category for the treatment of new medical conditions following cohort inception. RESULTS: The cohorts were well-matched for age, gender and duration of follow-up. Patients having undergone bariatric surgery had significant reductions in mean percent initial excess weight loss (67.1%, P <0.001) and in percent change in initial body mass index (34.6%, P <0.001). Bariatric surgery patients had higher total costs for hospitalizations (per 1,000 patients) in the first year following cohort inception (surgery cohort = CDN 12,461,938 dollars; control cohort = CDN 3,609,680 dollars). At 5 years after cohort inception, average cumulative costs for operated patients were CDN 19,516,667 dollars versus CDN 25,264,608 dollars, for an absolute difference of almost CDN 6,000,000 dollars per 1,000 patients. CONCLUSION: Weight-reduction surgery in morbidly obese patients produces effective weight loss and decreases long-term direct health-care costs. The initial costs of surgery can be amortized over 3.5 years.

Body Mass Index↗