Biomedical subjects

Monika Maciejczyk-Pencuła

Publications and source records attributed to Monika Maciejczyk-Pencuła.

5 recordsLinked to original sources

PubMed2005

Serum acute phase protein concentrations after hysterectomy with and without low-molecular-weight heparin thrombosis prophylaxis.

Background. Low-molecular-weight heparin (LMWH) is recommended for venous thrombosis prophylaxis. There are several lines of evidence that heparins exhibit anti-inflammatory properties in addition to their anticoagulant activity. Therefore, we decided to estimate the concentrations of C-reactive protein (CRP) and haptoglobin, as acute-phase proteins, in the blood serum of patients who underwent total abdominal hysterectomy with and without the LMWH administration. Method. Forty-two women were studied, including 26 patients treated with enoxaparin and a group of 16 women without thrombosis prophylaxis. Haptoglobin and CRP concentrations were measured in serum samples obtained before the operation and also 8, 24, 48, 72, 96, and 192 hr after surgery. Results. Serum CRP level measured 8 hr after the operation was significantly higher in the group without thrombosis prophylaxis, however, no statistically significant differences in the concentration of CRP between studied groups in the other time periods were found. There were no statistically significant differences in serum haptoglobin levels between the groups of patients in all time periods. Conclusion. Administration of low-molecular-weight heparin may affect CRP production, however, further studies are still needed in order to clarify the exact immunosuppressive action of heparins.

Acute-Phase Proteins↗

PubMed2004

Serum cortisol and acute phase protein concentrations after hysterectomy with and without peritoneal sutures.

OBJECTIVE: Although non-closure of the peritoneum still remains a controversial problem, to our knowledge there have been no studies comparing stress response in women who either have or have not had peritoneal sutures. Therefore, we decided to assess cortisol, C-reactive protein and haptoglobin levels in serum obtained following hysterectomy in both sets of patients. MATERIAL AND METHODS: Forty-nine women after total abdominal hysterectomy with bilateral salpingo-oophorectomy were studied, including 28 patients with non-closed peritoneum and 21 women after peritoneal sutures. Cortisol and acute phase protein levels were measured in serum samples obtained before the operation and also 8, 24, 48, 72, 96 and 192 h after surgery. RESULTS: There were no significant differences in the concentration of cortisol and C-reactive protein in blood serum between groups of patients in all time periods. Serum haptoglobin level was not statistically significant between the examined groups in 8, 24, 48, 72, 96 h, but after 192 h it increased significantly in a group of patients who had received peritoneal closure operations. CONCLUSIONS: Our results suggest that closure of parietal and visceral peritoneum does not provide any benefits during the postoperative period.

Acute-Phase Proteins↗

PubMed2004

[Decrease of paraoxonase activity in the first day after abdominal operations in women].

INTRODUCTION: Paraoxonase (PON1) is one of enzymes participating in antioxidative defence mechanism, which protects the organism from the results of action of reactive oxygen species. PON1 is an esterase contained in plasma high density lipoproteins (HDL) which protects HDL from peroxidation and plasma membranes from free radical injury. PON1 serum activity is diminished in some diseases (atherosclerosis, diabetes, coronary artery disease) and after cardiosurgery operations. But there is no information about changes in PON1 activity after abdominal operations. THE AIM: Of this study was the assessment of PON1 serum activity after the abdominal operations in women. MATERIALS AND METHODS: 40 women operated in the 1st Department of Gynaecology of Lublin Medical University were studied, including 34 patients after total abdominal hysterectomy with salpingo-oophorectomy and 6 patients after myomectomy or cyst enucleation. The blood to experiments was collected before operation, and 8 and 24 hours after. PON1 serum activity was assessed spectrophotometrically toward two synthetic substrates: paraoxon and phenyl acetate. RESULTS: PON1 activity toward paraoxon before operation was 146.8 +/- 17.3 U/ml, and after 8 and 24 hours after 107.6 +/- 11.9 U/ml and 119.9 +/- 16.9 U/ml, respectively (results statistically significant). PON1 activity toward phenyl acetate (arylesterase activity) before operation was 182.7 +/- 16.4 U/ml and did not significantly changed after the surgery. CONCLUSION: It is observed decreased PON1 serum activity in the early postoperative period after abdominal operations in women, what can be connected with the utilisation of PON1 in antioxidative defence mechanism.

Adult↗

PubMed2004

[Pre-pubic TVT in the treatment of urinary incontinence in women. Description of surgical technique and initial results].

Tension-free vaginal tape (TVT) has within the last decade become one of the most popular procedure for treatment of female urinary stress incontinence. It is still persistent the risk of complications peri- and postoperative in spite of high efficacy of this method. Investigators still have been looking for new variations of this method to diminish the risk of complications and to maintain the efficacy of the treatment. The aim of this study is the description of the pre pubic TVT method and the preliminary short time (3 month) results of treatment. The results of pre-pubic TVT treatment were compared with "classic" TVT method. The pre-pubic TVT technique was performed in 25 women, operated for stress incontinence. The average operation time was 19 min (10-30 min). During the operation in one of patients there was excessive bleeding from venous plexes of vagina during preparation of tissues and in 4 of them it was perforation of vaginal mucosa during introducing of needle with tape. All these complications were recognised and corrected during the surgery. The mean hospitalisation time was two days. Our 3-months observations allow to confirm that efficacy of pre-pubic TVT is similar to the "classic" method, but the frequency of complications is lower in the pre-pubic TVT. There were no postoperative complications and voiding dysfunctions.

Adult↗

PubMed2003

[Non-closure of the peritoneum after hysterectomy--postoperative clinical assessment].

Dynamic development in modern medicine permanently brings the modifications of operation techniques. Both closure and non-closure of the peritoneum after gynecologic operations has been discussed recently. According to clinical observations provided by many authors, the controversial problem of non-closure of the peritoneum is still under discussion. Thus we decided to assess the influence of closing or non-closing of the peritoneum on short-term postoperative morbidity. The patients operated because of uterine myomae were the participants of our study. Total abdominal hysterectomy with suturing or non-closing of visceral and parietal peritoneum was performed. Our study revealed that non-closing of the peritoneum did not increase the amount of postoperative complications and it seemed to be a safe procedure.

Adult↗