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Monika Polak

Publications and source records attributed to Monika Polak.

5 recordsLinked to original sources
PubMed2004

Lipid peroxidation in diabetic retinopathy.

Oxidative stress has been implicated in pathogenesis of diabetic retinopathy. It has been hypothesized that hyperglycaemia may damage vascular endothelium and retina by inducing the synthesis of oxidant reactive species. The aim of the present study was to estimate lipid peroxidation by detecting the concentration of malondialdehyde and 4-hydroxynonenal in diabetic patients with retinopathy, subjects without retinopathy and the reference group. Sixty-one patients were studied, including 30 patients with severe non-proliferative retinopathy in NIDDM and 31 diabetic patients without retinopathy. The reference group were 11 systemic healthy patients. Concentration of malondialdehyde and 4-hydroxynonenal was measured in plasma sample using a Lipid peroxidation Assay Kit (Calbiochem-Novabiochem Corp.). The concentration of lipid peroxidation products in patients with retinopathy was statistically significantly elevated in comparison to diabetic patients without retinopathy (p < 0.001) and the reference group (p < 0.001). We do not notice any significant differences in levels of MDA and 4-HNE between patients without diabetic retinopathy and the reference group. In view of our results we can conclude that oxidative stress is an important risk factor in the development of diabetic retinopathy.

Aldehydes↗
PubMed2002

Results of Nd:YAG laser capsulotomy in posterior capsule opacification.

The most common postoperative complication of cataract extraction is posterior capsule opacification. It causes the deterioration of visual acuity, however, there is no effective method to prevent it. The posterior capsule opacification is treated by surgical or laser capsulotomy. The authors analysed the results of Nd:YAG application in discission of the opacified posterior capsule. Twenty-eight consecutive cases (23 patients) of extracapsular cataract extraction and phacoemulsification with implantation of posterior chamber intraocular lenses were reviewed. In all cases of capsulotomy the Nd:YAG laser of Q-switch Zeiss type was applied. The improvement of visual acuity was achieved in 25 cases (89%). The best visual acuity (0.8-1.0) was obtained in 72% of eyes and in 22% the improvement was from 0.25 to 0.5. In two cases visual acuity after capsulotomy deteriorated because of concomitant glaucoma. In one case repeated capsulotomy did not turn out to be successful. It was caused by diabetic neuropathy of the optic nerve. We did not observe any serious complications following Nd:YAG laser capsulotomy described by the others: the intraocular pressure elevation, cystoid macular edema, intraocular lens injury, retinal detachment, iridocyclitis. Nd:YAG laser capsulotomy is one of the best methods of treatment of posterior capsule opacification. It appears to be effective, safe, non-invasive and it does not require patient hospitalisation.

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