Isotonic fluid absorption during hysteroscopy resulting in severe hyperchloremic acidosis.
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Absorption↗
Biomedical subjects
Monika Schäfer
Publications and source records attributed to Monika Schäfer.
Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cells.
Oxidative stress is involved in several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and ischemic reperfusion injury (stroke). We have established clones of the murine hippocampal neuronal cell line HT22, which are resistant to the oxidative stress-causing agents glutamate and hydrogen peroxide, respectively. These cell clones show a mutual cross-resistance to other oxidative stressors, but not to essentially non-oxidative neurotoxins. We have discovered that the amount of phosphorylated, inactive glycogen synthase kinase (GSK) 3beta is elevated in both resistant clones. Pharmacological inhibition of GSK-3beta with lithium chloride in the sensitive parental neuronal cells results in an increased tolerance to glutamate and hydrogen peroxide, suggesting that GSK-3beta is involved in the control of oxidative stress resistance in these cells.
Animals↗
[A modern Kaspar Hauser].
OBJECTIVE AND METHODS: The case of a mentally disturbed young man is described, whose identity could not be revealed over more than four months. It is compared to Kaspar Hauser, similarities and differences are highlighted. RESULTS: The "Kaspar Hauser of Stuttgart" is retrospectively revealed as a young man with experiences of severe deprivation. The missing case history and independent history were an obstacle in the treatment, albeit not fundamental, advantages being reached with a relation-oriented approach. CONCLUSIONS: Informations obtained after clarification of the identity of the young man suggest a multiplication of unfavourable circumstances, leading to sub-optimal treatment and finally the "Kaspar-Hauser-Situation". Contributing were his belonging to the less integrated group of migrants in Germany, as well as severe deprivation in the family and a generally sub-optimal treatment of mentally disturbed young patients.
Adolescent↗
Trigeminal evoked potentials and sensory deficits in atypical facial pain--a comparison with results in trigeminal neuralgia.
Trigeminal evoked potentials (TEPs) and sensory deficits in eighty-three patients admitted for first surgical treatment of facial pain were retrospectively analysed. Thirty-seven patients suffered from trigeminal neuralgia (TN), 10 from symptomatic TN (sTN), and 36 from atypical facial pain (AFP). Eighteen percent of the TN patients reported sensory deficits on the pain side, but 35% had delayed ipsilateral N13 waves. Of the sTN patients, 60% had either sensory deficits or a pathological corneal reflex and 62.5% a pathological N13. Of the AFP patients, 61% complained of sensory deficits, but only 31% had a pathological N13. The percentage of pathological P19 waves was slightly lower (20%, 50%, and 11%, respectively), but showed a similar trend. Normal TEPs were found even in the presence of a sensory deficit (reported only in the AFP group). These findings may add weight to the hypothesis of underlying psychiatric disorders in AFP.
Blinking↗