Biomedical subjects

Muhammad Jan

Publications and source records attributed to Muhammad Jan.

4 recordsLinked to original sources

PubMed2006

Transient myocardial dysfunction after smoke inhalation.

Acute onset, transient (reversible) myocardial contraction abnormality has been described in patients with acute non-cardiac illness and after acute emotional stress. Such reversible myocardial contraction abnormalities may occur via mechanisms other than reduction in epicardial coronary blood flow. We report a case of acute transient cardiomyopathy after smoke exposure. The patient developed acute heart failure without evidence of carbon monoxide poisoning that resolved within 4 days. An association between brief smoke exposure without carbon monoxide poisoning and acute heart failure has not been previously described.

Acute Disease↗

PubMedDate not supplied

Evaluation of combined effect of verapamil and ranitidine on the volume and acidity of carbachol induced gastric secretion.

BACKGROUND: This study was conducted to observe the effect of H2-receptor antagonist Ranitidine and calcium channel blocker Verapamil on the volume, free and total acidity of carbachol induced gastric secretion. METHODS: Twenty four albino rats of Sprangue Dawley strain weighing 150-200 grams were used. Animals were divided into Four groups. After fasting for 48 hours, pylorus of each animal was ligated, verapamil 10 mg/Kg, ranitidine 0.5 mg/Kg and carbachol 600 microg/Kg body weight were administered intraperitoneally. RESULTS: It was observed that ranitidine significantly reduced both the volume and acidity (p<0.001). Similarly Verapamil also significantly reduced the volume, free and total acidity when compared to carbachol alone. When verapamil was used in combination with ranitidine 15 minutes before carbachol, there was further inhibition of volume and acidity as compared to ranitidine alone. This reduction was statistically highly significant (p<0.001). CONCLUSION: Our study suggests that combined therapy of verapamil and ranitidine may have clinical usefulness in the management of severe peptic ulcer and Zollinger Ellison Syndrome.

Animals↗

PubMedDate not supplied

Comparison of effects of extract of Myristica fragrans and verapamil on the volume and acidity of carbachol induced gastric secretion in fasting rabbits.

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This study was undertaken to find out the effects of extract from Myristica fragrans which contains documented natural Calcium channel blocker and Verapamil on volume and acidity of Carbacol induced gastric section. Their effects were also compared to find out any difference in their efficacy. METHODS: Thirty rabbits of local breed, weighing 1-1.5 kg were used. The animals were kept on fasting for 48 hours, after which the pylorus of each animal was ligated. Verapamil 10 mg/kg, Myristica fragrans 500 mg/kg and Carbachol 600 microg/kg body weight were administered intraperitoneally. RESULTS: It was found that extract from Myristica fragrans reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Verapamil had also the same effects. When the difference of mean for verapamil was compared with that of extract, all these differences were found statistically non significant indicating that extract has similar effect as that of Verapamil on all parameters included in study. CONCLUSION: The effect of Myristica fragrans is similar to Verapamil and therefore it can be used effectively in the treatment of peptic ulcer and all other conditions that require calcium channel blockers for the treatment of these disorders.

Animals↗

PubMedDate not supplied

Comparison of verapamil and cimetidine for their effects on volume and acidity of Carbachol induced gastric secretion in fasting rabbits.

BACKGROUND: Peptic ulcer is a common ailment for which over production of gastric acid is the main cause. This study was undertaken to find out the effects of Calcium channel blocker Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and total acidity of carbachol induced gastric secretion and their effects were also compared. METHODS: Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on fasting for 48 hours after which the pylorus of each was ligated. Verapamil 10mg/kg, Cimetidine 2.5 mg/kg and Carbachol 600 microg/kg body weight were administered intrapertoneally in pylorus ligated rabbits. RESULTS: It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. when the difference of means values brought about by verapamil were compared with those of Cimetidine, all these differences were found statistically non significant, indicating that Verapamil has similar effect as that of Cimetidine on all parameters included in study. CONCLUSION: Verapamil has significant effect on volume and acidity of carbachol induced gastric secretion.

Animals↗