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Biomedical subjects

Muriel Vogel-Sprott

Publications and source records attributed to Muriel Vogel-Sprott.

7 recordsLinked to original sources
PubMed2006

Neuropsychological profile of acute alcohol intoxication during ascending and descending blood alcohol concentrations.

Numerous studies have investigated the effects of alcohol on motor processes during rising and declining blood alcohol concentrations (BAC), however, relatively little research has examined the alcohol-induced impairment of cognitive performance on the two limbs of the BAC curve. This experiment administered a neuropsychological test battery to assess the degree to which rising and declining BACs during an acute dose of alcohol impair nine cognitive processes within an individual. In all, 20 healthy male social drinkers (university students) were assigned to one of two groups (n = 10) who received a beverage containing either 0.0 g/kg (placebo) or 0.65 g/kg alcohol and performed the test battery when BAC was increasing and was decreasing. Comparisons of alcohol and placebo groups revealed impairment (slower response and/or increased errors) in seven of the cognitive processes: long-term verbal memory; information processing; declarative memory; inhibitory control; short-term visual memory; long-term visual memory, and visual-spatial working memory. However, some processes were impaired only during rising BACs whereas the impairment of others during declining BACs was evident only by an increase in errors. These results show cognitive tasks performed by an individual are not similarly affected by rising and declining BACs, and call attention to the importance of assessing both speed and accuracy on both limbs of the BAC curve. The particular cognitive processes differentially affected by rising vs declining BACs raised the possibility that acute alcohol intoxication may impair one cerebral hemisphere to a greater degree than the other, and this could be explored by neuroimaging techniques.

Adult↗
PubMed2005

Acute dose of alcohol affects cognitive components of reaction time to an omitted stimulus: differences among sensory systems.

RATIONALE: The possibility that moderate blood alcohol concentrations (BACs) may impair cognitive processes before disturbing motor functions has raised concern about the safety of BACs <or=80 mg/100 ml. Reaction time (RT) to the presentation of a stimulus or to the omission of a regularly occurring stimulus has been fractionated into independent premotor (cognitive) and motor (movement) components. It has been suggested that cognitive processes may be impaired at lower BACs than are motor processes, but the effects of moderate rising and declining BACs on these component RT measures have not been investigated. OBJECTIVES: An omitted stimulus RT task was used to test the hypothesis that moderate rising BACs impair (slow) premotor RT (PMRT) when motor RT (MRT) remains unaffected. The task included visual, auditory, and tactile stimuli to explore differences in sensory sensitivity to alcohol. METHODS: Thirty male social drinkers were randomly assigned to three groups (n=10) that received 0.62 g/kg alcohol, 0.8 g/kg alcohol, or a placebo (0 g/kg). All participants performed the task three times: baseline and during rising and declining BACs. RESULTS: Comparisons of the alcohol and placebo groups showed rising BACs slowed PMRT and had no detectable effect on MRT. Impairment in visual PMRT occurred under both alcohol doses. Auditory PMRT was impaired only under the 0.8 g/kg dose, and tactile PMRT was unaffected. CONCLUSIONS: Cognitive functions are impaired by moderate increasing BACs that do not affect motor movement, and the tactile sensory system may be relatively insensitive to this impairment.

Acoustic Stimulation↗
PubMed2005

Effects of alcohol and performance incentives on immediate working memory.

RATIONALE AND OBJECTIVES: The Sternberg Memory Scanning task was used to test the hypotheses that immediate working memory (WM) would be impaired during moderate rising blood alcohol concentrations (BACs), and provision of a rewarding incentive for good performance under alcohol would counteract this impairment. METHODS: Two groups (n=18) of social drinkers received either 0.62 g/kg alcohol (A) or a placebo (P). Reward (verbal feedback and money) for good performance was provided to another pair of alcohol and placebo groups (n=18) (AR and PR). All participants completed two tests when BACs in the alcohol groups were rising (68 and 80 mg/100 ml) and two tests during declining BACs (73 and 64 mg/100 ml). RESULTS: Comparisons of A and P groups showed that rising BACs impaired immediate WM [increased errors, slowed rate of mental scanning, slowed reaction time (RT) when a larger number of items had to be held in WM]. Comparisons of AR and PR groups showed that reward for good performance during rising BACs counteracted impairment in scanning rate and RT but did not reduce errors. Tests during declining BACs of 73 mg/100 ml indicated some symptoms of impairment abated before others. When BAC declined to 64 mg/106 ml, the groups no longer differed on any measure of WM. CONCLUSIONS: An acute dose of alcohol can impair aspects of immediate WM performance while BACs are rising, and some of these effects can be reversed when incentives to perform well are provided.

Administration, Oral↗
PubMed2005

Behaviorally fractionated reaction time to an omitted stimulus: tests with visual, auditory, and tactile stimuli.

Two experiments tested the adequacy of behavioral criteria to fractionate reaction time (RT) into independent premotor (cognitive) and motor components. Healthy participants performed an omitted stimulus reaction time task in which they responded to the termination of a train of lateralized visual, auditory or tactile stimuli. Exp. 1 with 48 participants (24 men) showed premotor RT was independent of motor RT in each sensory modality and did not differ as a function of side of presentation or sex. Repeated tests administered in Exp. 2 (N= 12) also showed no significant association between the behaviorally fractionated measures. These results are comparable to those obtained using muscle potential to fractionate RT and suggest behaviorally fractionated premotor and motor RT could be a reliable, useful tool in the assessment of cognitive and motor processing in different sensory modalities of healthy people or those with brain injury, disease, or drug-induced disturbances.

Adolescent↗
PubMed2004

Drinking on campus: self-reports and breath tests.

OBJECTIVE: Concern about excessive alcohol consumption by college students has been raised by surveys indicating that more than 40% of students are "heavy" drinkers. This definition is based on students' reports of consuming five or more drinks (four or more for women) on an occasion sometime during the past 2 weeks. The present survey examines the degree to which this 2-week 5+/4+ drink criterion characterizes a student's pattern of alcohol use, and whether a 5+/4+ criterion for a drinking occasion is a valid indicator of high blood alcohol concentration (BAC). METHOD: Students (N = 856, 70% male) were interviewed as they returned home between 10 PM and 3 AM. Students reported their drinking of the past 2 weeks and of the night they were interviewed, then provided breath samples to determine their BAC. RESULTS: Among the students in the sample classified as "heavy" drinkers on the basis of self-reports, 49% had zero BAC on the night they were interviewed. Those who reported consuming 5+/4+ drinks the evening of the interview had a mean BAC <0.08%. The distribution of BACs in the entire sample showed 74.4% of students had a BAC of zero and 11.8% had a BAC <0.05%. Very high BACs (i.e., > or =0.15%) were rare (1.3%). CONCLUSIONS: Self-reports of consuming 5+/4+ drinks on at least one occasion during the previous 2 weeks did not reliably identify a pattern of heavy drinking. Moreover, reports of 5+/4+ drinks on an occasion were not necessarily associated with high BACs.

Alcohol Drinking↗
PubMed2002

Cognitive processes and motor skills differ in sensitivity to alcohol impairment.

OBJECTIVE: Research reviews have suggested that cognitive and motor skills are not equally sensitive to a moderate dose of alcohol; they disagree, however, on which type of task is more sensitive to impairment. This issue is addressed in two experiments testing a cognitive and a motor skill task performed by the same person at comparable blood alcohol concentrations (BACs) during a moderate dose of alcohol. METHOD: A motor skill task (PR) and a rapid information processing (RIP) task requiring no learned motor skill were performed in counterbalanced order, and tests on the pair of tasks occurred at intervals as BAC rose and declined. In the first experiment, two groups of male social drinkers (each n = 10) received either a moderate dose of alcohol (0.62 g/kg) or placebo and performed the tasks with no consequence for performance. The second experiment comprised four groups (each n = 14) to verify and extend the results to a situation in which unimpaired performance under alcohol was rewarded on one or both tasks. RESULTS: In both experiments, impairment on the PR task tended to increase and diminish with rising and declining BACs, whereas impairment on the RIP task showed no such pattern. Reinforcement reduced the degree of impairment displayed on each task, but the different task profiles of impairment were still evident. CONCLUSIONS: The results indicate how disagreement over the sensitivity of cognitive and motor skills to a moderate dose of alcohol may occur when impairment is only assessed at some particular BACs. Theoretical and practical implications of the findings are discussed.

Adult↗