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Biomedical subjects

N A Belova

Publications and source records attributed to N A Belova.

17 recordsLinked to original sources
PubMed1999

[Current problems in diagnosis and treatment of hereditary disturbances of growth and development in children].

The authors' long-term experience in diagnosing and treating childhood hereditary growth and developmental disturbances, such as genetic diseases of connective tissue, amino acid metabolic disturbances, rickets-like diseases, mitochondrial abnormalities, Rett syndrome, and fragile X syndrome is presented. The findings suggest that multimodality treatment is highly effective in treating children with hereditary growth and developmental disturbances in genetic care.

Developmental Disabilities↗
PubMed1993

[Automated genetic register and computer support for the physician's diagnostic decisions].

Computer-based genetical register "GENREG" allows to carry out a prophylactic medical examination for families with children, having hereditary diseases, multifactorial pathology and congenital developmental defects of various nature, and also epidemiological examination. Automated consultative system for pre-laboratory diagnosis of genetically determined diseases after the phenotypical manifestations "DIAGEN" allows to identify up to 1200 nosologic units; diagnostic value (or weight) of the signs according to physician's evaluation is taken into consideration. The system sorts out a narrow differential-and-diagnostic row and information about specific laboratory and functional changes for every selected diagnosis. Efficiency of the system is over 94% (after the next laboratory findings). The results of computer diagnosis and final physician's diagnosis, and also questionnaire of a child are stored in archives (files) of the "DIAGEN" system. Both of the systems are realized on PC/AT IBM-compatible computer.

Child↗
PubMed1989

[The combined treatment of osteogenesis imperfecta in children].

The authors present the results of complex drug and orthopaedic treatment of children with imperfect osteogenesis. 40 patients were treated with a somatotropic hormone, calcitrin and vitamin D metabolites (oxydevit and dihydrocholecalciferol). In 20 of these patients corrective osteotomies of the long bones of the lower extremities combined with metal osteosynthesis with rods and massive plates were performed. In a number of patients osteoplasty with long cortical allografts was made. After the treatment all the children were able to move independently either with the aid of unloading orthopaedic apparatuses (17 patients), or without them (3 patients).

Bone Plates↗
PubMedDate not supplied

Long-term changes in hippocampus and neocortex EEG spectra in response to pharmacological treatments affecting the cholinergic system.

Statistical analysis of EEG spectra averaged over 10-min intervals showed that in rats performing free behavior, peripheral administration of the acetylcholinesterase inhibitor physostigmine induced long-lasting characteristic changes (lasting tens of minutes) in the electrical activity of the dorsal hippocampus (field CAI) and the somatosensory cortex. An increase in the physostigmine dose from 0.05 to 1 mg/kg shifted the peak of the theta rhythm to lower frequencies (3.6-4.9 Hz) without a change in power at this frequency, though there was a decrease in power at 5.7-11.9 Hz. The power of the beta-1 rhythm (13.8-16.4 Hz) was also strongly suppressed. In contrast, the power of the beta-2 rhythm (20.3-26.5 Hz) increased several-fold in a non-linear fashion. Scopolamine suppressed all the changes induced by physostigmine, demonstrating the important role of m-cholinoceptors in changes in EEG spectra. The high dose of physostigmine caused inversion of the power of the beta-2 rhythm: unlike the situation obtaining in controls, the beta-2 power in the hippocampus became significantly greater than that in the neocortex. These data suggest the conclusion that overall significant increases in endogenous acetylcholine levels lead to decreases in the functional activity of the hippocampus and neocortex and that the mechanisms of cholinergic modulation of the theta and beta rhythms are significantly different. It is suggested that conditioned reflex switching, contextual learning, and dissociated sates of memory and consciousness are to a significant extent dependent on long-term changes in the oscillatory activity of the hippocampus and neocortex.

Animals↗
PubMedDate not supplied

[Dependence of gravitotropic reaction in segments of flax stems on frequency and amplitude of variable components of a weak combined magnetic field].

We determined the dependence of the effect of weak combined magnetic field (CMF) tuned to Ca2+ resonance (Ca(2+)-CMF) on the rate of gravitropic response in apical segments (25 mm long) excised from the 4-day-old seedlings of flax (Linum bienne) on the amplitude and frequency of the alternating component of Ca(2+)-CMF. The results indicate that test-systems derived from plant and animal sources are affected by Ca(2+)-CMF via an identical mechanism.

Flax↗
PubMedDate not supplied

[Long-term changes in EEG spectra of the hippocampus and neocortex during pharmacological action on the cholinergic system].

Statistical analysis of EEG spectra averaged over 10-min periods showed that inhibitor of acetylcholinesterase physostigmine induced the long-term (tens of minutes) characteristic changes in the electric activity of the dorsal hippocampus (CA1 field) and somatosensory cortex of unrestrained rats. With increasing the physostigmine dose from 0.05 to 0.5 or 1 mg/kg the averaged power of the theta-rhythm did not rise in the range of 3.6-4.9 Hz and was suppressed in the range of 5.7-11.9 Hz both in the hippocampus and neocortex. The maximal frequency shifted to the left (from 3.6-6.4 to 3.6-4.9 Hz). In contrast to this, the averaged power in the delta (1-1.5 Hz)-I and beta-2 ranges (20.3-26.5 Hz) significantly nonlinearly increased and that of the beta-1 substantially decreased. Scopolamine eliminated all extrema of the hippocampal and neocortical EEG spectra induced by physostigmine, which is indicative of the role of M-cholinoreceptors in these effects. The increased dose of physostigmine (1 mg/kg) produced inversion of the ratio between the averaged power of beta-2 in neocortex and hippocampus: it became significantly higher than in the neocortex. All these data suggest that the mechanisms of cholinergic modulation of the theta- and beta-rhythms are essentially different. We think that significant enhancement of the content of endogenous acetylcholine content produce a long-term tonic decay of the functional activity of the hippocampus and neocortex and play an important role in the mechanisms of dissociated states of memory and consciousness, contextual learning and conditioned switching.

Animals↗
PubMedDate not supplied

[Activation and inhibition of the gravitropic response in the flax stem segments exposed to the permanent magnetic field with magnetic density ranging from 0 to 350 microT].

It was found that the rate of gravitropic bending in apical segments excised from 4-day-old etiolated seedlings of flax Linum bienne is strongly and nonlinearly dependent on the value of the magnetic flux density of a static magnetic field, BDC, in the range from 0 to 350 microT. The gravitropic bending is stimulated at 0 < or = BDC < or = 2 microT and 200 < or = BDC < or = 350 microT but is inhibited at 100 < or = BDC < or = 170 microT relative to control samples being in the magnetic field of the Earth equal to 46.5 microT.

Flax↗
PubMedDate not supplied

[Effects of extremely weak alternating magnetic fields on the plant gravitropism].

It was shown that the rate of gravitropic response in apical segments excised from the 4-day-old seedlings of flax (Linum bienne) may be substantially influenced by combined magnetic fields (CMF) of two different types: 1) CMF tuned to the parametric resonance for Ca2+; 2) CMF containing extremely weak alternating component with the values of magnetic density ranging from 10(-6) to 10(-10) T. Our experimental data indicate that CMF affect the gravitropic response via at least two different mechanisms. The first one corresponds to the ion parametric resonance well established earlier in studies with test-systems prepared from animals. The origin of the bioeffects induced by CMF containing extremely weak alternating component remains to be established.

Flax↗