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Biomedical subjects

N A Chebotar'

Publications and source records attributed to N A Chebotar'.

50 records · Page 3Linked to original sources
PubMedDate not supplied

[The effect of amniotic fluid taken from women in labor on the morphofunctional development of fetal and newborn rats].

Amniotic fluid from women was injected intra-amniotically to rats at the 14th day of pregnancy in a dose 0.3 ml. Morphological and functional parameters of embryonic development of rats and EMG activity of rat puppies at the age of 30-34 days differed from control ones with respect to the degree of maturity and motor disturbances of newborn babies. The data obtained reveal not only evident but also masked forms of motor pathology which was observed in children later, namely to 6-9 months. Chronic motor pathology in rat puppies was unilateral with central motor disturbances in babies being directly related to the degree of these disturbances.

Amnion↗
PubMedDate not supplied

[Astrocyte death in organotypic cultures of fetal spinal cord from rats with unilateral micromelia].

Growth and differentiation of neurons and glia in spinal cord explants of 16 days old rat fetuses with teratogen-induced left-sided micromelia were studied. Progressive destruction of astrocytes that differentiate in interstitial zone of cultures was observed in 37% of explants of the left side, while the development was normal in cultures of the right side. Possible mechanisms leading to destruction of astrocytes in cultures of spinal cord regions that innervate anomalous limbs are discussed.

2,2'-Dipyridyl↗
PubMedDate not supplied

[Mutagenic action resulting from the preovulatory administration of chloridine on preimplantation rat embryos].

Pyrimethanine (2 and 5 mg/kg) injected to the adult female rats just before ovulation causes significant dose-dependent reduction in embryo cleavage rate. Pyrimethamine administered in a dose of 2 mg/kg before ovulation has no mutagenic effect on 5-day rat embryos, while 5 mg/kg induced chromosomal aberrations in 14.3% of all 5-day embryos as compared to only 6.3 % embryos with chromosomal aberrations in the control animals. The most common types of chrmosomal aberrations induced by pyrimethamine are trisomy and chromosomal mosaicism.

Animals↗
PubMedDate not supplied

[The mechanisms of the teratogenic action of alcohol].

Under study was the influence of different doses and methods of administration of ethanol on embryogenesis of rats and the effect of some shifts in homeostasis of a female rat on a manifestation of teratogenic effect of ethanol. Embryogenesis of rats is resistant to action of ethanol and acetaldehyde. Shift in the acid-base balance to the acid side is not thought to be determining in the mechanism of the appearance of the fetal alcohol syndrome, while the embryotoxic effect of ethanol manifests itself against the background of an iron-deficient state of the maternal organism.

2,2'-Dipyridyl↗
PubMedDate not supplied

[The role of the maternal genotype in the realization of the embryotoxic activity of teratogens].

Against the background of the induced iron deficit ethanol (6.4 g/kg) causes aggravation of the embryolethal effect and anomalies in 15% of embryos in 14-day pregnant rats. Changes in the genome of rat males and females after the injection of the plasmid with a foreign gene at the stage of two pronuclei and the subsequent crossing with intact animals account for the increase in sensitivity of embryos to subteratogenic doses of sodium salicilate. The maternal organism disturbances have a more pronounced effect than the paternal ones.

2,2'-Dipyridyl↗
PubMedDate not supplied

[A comparison of the characteristics of chromosome nondisjunction in the first maturation division of mouse oocytes heterozygous for balanced structural rearrangements of the chromosomes].

Peculiarities of non-disjunction of chromosomes in the first meiosis of maturation of oocytes in mice heterozygous in the Robertsonian and nonuniform reciprocal translocations have been determined. Mice, heterozygous in one Robertson's translocation, had general frequency of chromosomal non-disjunction in the 1st meiosis of oocyte maturation equal to 17%; by two Robertsonian translocations the total frequency of genetically deficient oocytes amounted to about 77%, in case of unequal reciprocal translocation--to 50%. In two latter cases genetic disturbances were due to unbalanced euploid chromosome sets.

Animals↗
PubMedDate not supplied

[The embryotoxic effect in rats exposed to the blood serum of newborn infants tested for the presence of transfer factors].

Pregnant rats (day 14 of gestation) received intraamniotic injections of newborn human serum. Transfer factors (TF) present in injected serum produced significant embryotoxic and teratogenic effects, as well as changes in coordination of motor activity (EMG) in newborn rats. The extent of embryological disturbances and the motor activity of 33- to 34-day old recipient rats depend on TF concentration (at serum dilution 1:2) and on the state of infant's motor functions ("normal" group and "risk" group). The results obtained allow to objectively determine the pathogenic effect of serum TF on embryotoxicity and formation of motor coordination in the donor infant.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[The prevention of congenital developmental anomalies in rats].

Preventive administration of Eleutherococcus XXX extract during prenatal and pre-embryonic periods of development prevents embryotoxic effect of subsequent treatment of pregnant rats with ethanol and sodium salicylate. Eleutherococcus abolishes embryotoxic and teratogenic effects of ethanol manifested against the background of experimental syndrome of iron deficit in pregnant females. Mechanism of its antiteratogenic action is probably based on stimulation of cell detoxification mechanisms, increase in energy potential of cells, as well as on stabilization of structural and functional state of cell membranes.

2,2'-Dipyridyl↗
PubMedDate not supplied

[The effect of benzine and formaldehyde on the prenatal development of rats with induced iron trace-element disorder].

Iron-deficiency anemia induced in the maternal organism markedly enhances embryotoxic and teratogenic effects of the studied pollutants: gasoline and formaldehyde. The prenatal effects of these drugs against the background of iron-deficiency state in pregnant females leads to development of the main feature of the tissue hypoxia, decompensated metabolic acidosis, in both the maternal organism and 20-day embryos.

2,2'-Dipyridyl↗