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Biomedical subjects

N A Endicott

Publications and source records attributed to N A Endicott.

12 recordsLinked to original sources
PubMed2004

Patterns of functional brain organization and migraine.

The purpose of this study was to examine the relationship between the patterns of functional organization of the brain, as evaluated by the number of anomalous brain conditions or phenomena (ABCP), and the prevalence of migraine in a group of 434 women with lifetime major depressive disorder. ABCP are conditions or phenomena which are clearly related to brain function whose prevalence significantly deviates from the statistical mean for the general population. Eighteen ABCP (e.g. mixed or left handedness, enuresis after age 5, learning and speech disorders) were used in this study as 'markers' for their associated patterns of functional brain organization. The relationship between the number of ABCP and the prevalence of migraine was highly significant. The correlation between the number of ABCP and the prevalence of migraine was 0.36 (P < 0.0001, confidence interval 0.26, 0.43). The prevalence of migraine in patients with no ABCP (n = 11) was 9%, while that of those with eight or more ABCP (n = 40) was 85%. This supports the hypothesis that there is a relationship between patterns of functional brain organization and migraine prevalence.

Adult↗
PubMed1999

Chronic fatigue syndrome in private practice psychiatry: family history of physical and mental health.

Forty-five psychiatric patients with chronic fatigue syndrome (CFS) were compared, using the case-control method, to two control groups selected from the same practice and matched on age, gender, and psychiatric diagnosis. The first control group (C-I, N=90) was selected on the basis of relatively good physical health. The second control group (C-II, N=45) was selected without regard to physical health. The reported family history of physical health revealed: the CFS mothers died at a younger age than the C-II mothers; both parents died before age 65 among the CFS parents more frequently than did the C-I parents; and the CFS parents had an increased prevalence of cancer, autoimmune disorders, and CFS-like conditions as compared to the families of one or both control groups. The reported family history of mental disorders revealed no significant differences in any of these conditions between the CFS patients and either control group.

Adult↗
PubMed1999

Role of brain organization in the pathogenesis of physical disease.

While genetic and environmental factors are known to make substantial contributions to the pathogenesis of physical disease, the role of the brain in these processes is largely unknown. It is hypothesized that the manner in which the brain is functionally organized is an integral factor in physical health outcomes, both positive and negative. It is further hypothesized that changes in certain patterns of the functional organization of the brain play a significant role in the pathogenesis of physical disease, mediating between an individual's genetic endowment, the environment, and other relevant brain systems to initiate, modulate and/or maintain these disorders. There are many currently available treatment modalities which have the capacity to change the pattern of functional brain organization. Such interventions have the potential to become valuable aids in both the treatment and prevention of physical disease.

Animals↗
PubMedDate not supplied

Psychophysiological correlates of 'bipolarity'.

Four hundred patients with major affective disorders were divided into six groups based on lifetime composite evaluations of the intensity, frequency, and duration of their high energy-positive mood states. This division was termed degree of 'bipolarity'. Within the non-bipolar I patients (groups 1-4) the rating of 'bipolarity' was found to be significantly positively associated with enuresis, classical migraine, Raynaud's disease, learning disorders, fingernail biting, and episodic phenomena. The possible significance of this non-bipolar I 'bipolarity' continuum construct is discussed. A significant discontinuity was found between 'bipolarity' groups 5/6 and group 4 in six of the 14 psychophysiologic conditions evaluated.

Adult↗
PubMedDate not supplied

Chronic fatigue syndrome in psychiatric patients: lifetime and premorbid personal history of physical health.

OBJECTIVE: This preliminary report compares a group of chronic fatigue syndrome (CFS) patients and controls on several variables of potential significance in the etiology of CFS. METHOD: The lifetime prevalence of reported physical disorders was compared among 46 CFS psychiatric patients, 92 relatively physically healthy psychiatric patients (C-I), and 46 psychiatric patients selected without regard to physical health (C-II). All patients were matched on age, sex, and psychiatric diagnosis and were drawn from the same psychiatric practice. The same groups were compared on a 7-point scale of lifetime physical health by three raters independently evaluating physical health narratives of the CFS patients up to the time of onset of CFS and that of the controls up to the corresponding age. RESULTS: The CFS patients had a significantly higher reported lifetime prevalence of irritable bowel syndrome (IBS), infectious mononucleosis-like syndromes (IM), infectious mononucleosis-like syndromes two or more times (IM x 2), and herpes (other than genital or perioral herpes) than one or both control groups. The CFS group also had a higher incidence of allergic rhinitis or asthma, IBS, IM, and IM x 2 than the combined controls. On the independent ratings, the CFS patients had significantly more impaired physical health up to the time of onset of the CFS than C-I at a comparable age. CONCLUSIONS: The findings suggest that a general health factor may be involved in the pathogenesis of some cases of CFS.

Adult↗