[Correction of immunologic reactivity in elderly patients with diffuse toxic goiter].
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Biomedical subjects
Publications and source records attributed to N A Epishina.
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Relapses of subacute thyroiditis, hypothyrosis or autoimmune thyroiditis more often develop in the patients with manifest immune shifts after therapy than in those with normal or moderately shifted immune status; this factor appears to be useful for the prediction of the disease outcome and for planning the treatment strategy.
A study of system of cellular and humoral immunity, unspecific defense in 187 patients with diffuse toxic goiter before and after treatment with mercasolyl revealed that despite the clinical effect, the agent did not essentially influence the content and functional activity of T-lymphocytes. The effect was more favourable on the content of immunoglobulins, titer of antithyroid antibodies. This was observed in mild and average severe course of the disease. It is suggested that mercasolyl effects lymphocytes synthesizing autoantibodies to the thyroid gland.
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