Biomedical subjects
Publications and source records attributed to N A Faruqi.
With topical therapy using dinitrochlorobenzene (DNCB), 36 (72%) out of 50 patients having alopecia areata showed regrowth of hair in 3 to 6 months time. Five (10%) patients experienced marked vesiculation and severe contact dermatitis requiring cessation of therapy. In 7 (14%) patients there was no response at all and 4 (8%) presented with other side-effects.
Development of perilobular hepatic fibrosis in rabbits after experimental ligation of the common bile duct was studied by microscopy. Twelve hours after the ligation, the lobular boundaries assumed prominence by appearance of row(s) of congested sinusoids around the distended perilobular canals of Hering. Seven days later, the lobular laminae limitans around such canals of Hering revealed myxomatous ballooning degeneration forming well defined inter-lobular bands (ILBs). On day 15 post-ligation, the residual sinusoidal endothelial-lining cells in the ILBs manifested hyper chromasia and occasional mitotic activity. It was followed, on days 25 and 35, by proliferation (hyperplasia) of the sinusoidal endothelium cells forming the portal tract like fibrotic tissue in the perilobular bands. These findings, showed the course of interlobular bridging necrosis along the bile preductules at the lobular circumferences and subsequently indigenous origin of the fibrotic tissue in the ILBs from the residual cells in the affected parenchyma independent of the portal tracts.
60 rats were divided into one control and 2 test groups of 20 male animals in each. Brains from control animals were taken out immediately after killing, and in the test groups (I and II) after brain cell damage by controlled autolysis at 37 degrees C for 6 and 18 h, respectively. Ten animal brains from each group were used for estimation of RNA content. The remaining 10 brains each of the test and control groups were homogenised in 0.001% thionin in formaline saline and incubated for thionin binding. The supernatants were read spectrophotometrically and the amount of thionin in the sediment(s) was calculated. The amount of sediment bound thionin in mg per 100 g brain was expressed as "thionin binding capacity" (TBC) of the brain. RNA content of the brain in control and test groups (I and II) was found to be 248.33 +/- 6.83 (100%), 210.83 +/- 8.61 (84.9%), and 190.83 +/- 10.21 (76.85%) mg per 100 g of the brain. Thionin binding capacity was 6.30 +/- 0.12 (100%), 4.82 +/- 0.17 (76.45%), and 3.49 +/- 0.39 (55.45%) mg per 100 g brain, in the 3 groups respectively. Both parameters showed similar decreasing tendencies with increasing brain damage i.e. in the groups I and II. The decrements of the 2 parameters were highly significant (P less than .001), hence, they could be utilised to assess the brain damage.
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