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Biomedical subjects

N A Iakovlev

Publications and source records attributed to N A Iakovlev.

At least 19 recordsLinked to original sources

[Chronic gastritis: keys to understanding the internal picture of the disease].

Complex examination of 311 patients with chronic gastritis allows to differentiate three clinical types of this disease. The first type is characterized by superficial mucous disorders with constant or increased secretory function and motility of the stomach. It has relapsing course with moderate decrease of patient's life quality. The abdominal pains and dyspepsia are observed only at periods of exacerbation. Anxiety-phobic and anxiety-depressive tendencies prevail in the mental status. The attitude to illness differs mainly by emotional-willed disorders. Insomnia is manifested by a slight delay in awakening. Focal atrophic gastritis with moderate decrease in secretory and motor functions of the stomach is typical for the second type. It develops as relapsing or monotonous suffering with insignificant decrease in patient's life quality. The pains and dyspepsia in residual state persist after exacerbation reduction. The changes in the mental status are rare. The patient's attitude to the illness is basically adequate. Slight disturbances of falling asleep prevail among sleep disorders. Diffuse atrophic gastritis with secretory failure reaching the degree of an achlorhydria and hypokinesis of stomach are observed in the third type. The course of the disease is basically monotonous with pronounced decrease in patient's life quality, with the obstinate abdominal pains and dyspepsia irrespective of the exacerbation phases of chronic gastritis. A combination of asthenic and neurotic complaints and combined sleep disorders are typical. Emotional disorders with disharmonization of personality accompanied by signs of their social and mental disadaptation are observed in the patient's mental status.

Abdominal Pain↗

[Pathogenetic characteristics of diseases of the peripheral nervous system in workers having contact with chromium compounds].

When analyzing the results of clinical neurologic, neurophysiologic, psychologic and laboratory instrumental study of 105 chromium-exposed patients with lumbosacral diseases of the peripheric nervous system there were detected clinical and pathogenetic characteristics of this pathology: distinct manifestations of segmental (homolateral) and generalized vegetovascular disorders, deficiency of sympathetic activation, emotional shifts accompanied by disquieting, depressive and hypochondriac tendencies, elevation of the cerebrovascular tension, body sensitization to chromium, increase in its blood serum and urine content. The account of these characteristics is very important for the improvement of the diagnostic process and raising efficacy of treatment of diseases of the peripheric nervous system in chromium-exposed patients.

Adult↗

[Risk factors of the development of the changes in the nervous system after exposure to chromium].

Due to the mathematical method of maximum probability it was established that under long-term chromium exposure possible factors of risk of changes in the workers' nervous system were as follows: hereditary and familial predisposition to allergic and vegetovascular disorders, negative Rh, the haptoglobin type 2-2 and the peculiarities of the major cerebral hemisphere functioning manifested by the decrease of sensomotor dominance. There was developed an estimating and prognostic table which made it possible to identify groups with adverse and favourable health forecast and to carry out necessary differentiated curative and preventive activities.

Adult↗