PubMed Health⌕ Search

Biomedical subjects

N A Karoli

Publications and source records attributed to N A Karoli.

18 recordsLinked to original sources
PubMed2006

[Endothelial dysfunction in patients with scleroderma systemic].

The purpose of the study was to investigate endothelial lesions and disturbances in the antithrombogenic and vasoregulative vascular wall functions in patients with scleroderma systematica (SS). The subjects of the study were 39 patients with SS aged 46 +/- 1.4 years. Vasomotor endothelial function was studied using reactive hyperemia and nitroglycerin tests. Cuff test was applied to evaluate antithrombogenic (anticoagulative and fibrinolytic activity) properties of the vascular walls. The number of desquamated endotheliocytes in blood was measured by J. Hladovec method (1978). The study found a tendency towards brachial artery narrowing, as well as hypertrophy of its wall in patients with SS. In 28.6% of SS patients flow-dependent dilatation did not exceed 10% (P < 0.01 vs. controls), which suggests the presence of disturbances in endothelium-dependent vasodilatation. SS patients displayed a significant increase in the number of circulating endotheliocytes (P < 0.05), which is evidence of endothelial lesion. The study found a significant decrease in fibrinolytic and anticoagulative activity of the endothelium in SS patients vs. controls. Thus, the study revealed endothelial lesion, as well as disturbances in the vasoregulative and antithrombogenic vascular wall activity in patients with SS.

Blood Flow Velocity↗
PubMed2006

[Mortality risk factors in patients with chronic obstructive pulmonary disease].

The aim of this prospective study was to determine the mortality risk factors in patients with chronic obstructive pulmonary disease (COPD). Eighty-six COPD patients were observed during 3 to 5 years. The presence and the severity of COPD were established according to COPD criteria (1998). Unfavorable outcomes were not noted only in 39 (45.3%) of the patients. Nineteen patients died; among those 15 patients died of the underlying disease and its complications. Death predictors in COPD may be listed as follows: forced expiratory volume in the 1st second is less than 40% normal value; SaO2 is less than 90%; the result of 6-minute walk test is less than 300 m; pulmonary arterial pressure is 40 mm Hg or higher; the thickness of the right ventricular (RV) wall is 0.7 cm or more; the volume of the RV cavity is 3.0 cm or more; the presence of relative right atrial dilation (the index of which is 0.9 or less); the presence of diastolic RV dysfunction; clinical symptoms of circulatory decompensation; a tendency towards the hyperkinetic type of circulation. The risk of death is higher in patients more than 60 years of age, those who have been experiencing dyspnea for more than 10 years, patients who have been smoking for more than 40 years, and patients with a smoking index of 50 pack-year or higher.

Exercise Test↗
PubMed2005

[Chronic obstructive lung disease and coronary heart disease].

It has been established that coronary heart disease, as well as arterial hypertension, is one of the most frequent illnesses that accompany chronic obstructive lung diseases (COLD). Certain data suggest that COLD increase the risk of the development of cardiovascular pathology 2 to 3 times. The purpose of the study was to establish coronary heart disease (CHD) rate among patients with COLD, and to determine the peculiarities of CHD in this category of patients. The subjects were 116 patients with COLD (mean age 53.5 +/- 1.13 years). The authors also analyzed lethality in the Pulmonary division of the clinic, where 41 patients had died in 1998-2003. CHD was diagnosed in 31 (26.7%) patients. The results show that CHD rate in COLD patients older than 60 is 1.5 times higher than that in those younger than 60, and 2.3 times higher than that in those younger than 50. The patients with and without CHD demonstrate significant difference in the severity of COLD and obstructive syndrome. The leading cause of death in COLD patients was respiratory and circulatory failure; also noticed was high myocardial infarction rate among those patients. Autopsies revealed signs of coronary artery atherosclerosis in 7 out of 9 patients. The obtained data suggest that CHD development is a regular phenomenon in COLD patients, especially in those exposed to other CHD risk factors. The risk group consists of patients with severe COLD; their examination requires special attention paid to possible CHD symptoms and painless myocardial ischemia, for early diagnostics and beginning of antianginal therapy.

Adult↗
PubMed2005

[Heart affection in patients with ankylosing spondiloarthritis].

AIM: To study features of heart disease in patients with alkylosing spondyloarthritis (ASA). MATERIAL AND METHODS: We examined 56 ASA patients. Most of the examinees had spinal problems, moderate activity, x-ray sacroileitis stage III. RESULTS: Pulmonary hypertension was detected in 60.7%, right ventricular (RV) hypertrophy--in 37.5%, RV dilation--in 30.4% patients. Interventricular septum, left ventricular posterior wall were thickened (p < 0.05). Left ventricular diastolic dysfunction was registered in 18.2% ASA patients. The changes correlated with the disease duration, spinal lesion, especially of thoracic part. CONCLUSION: Pulmonary hypertension is a frequent finding in ASA patients. Echocardiography (ECG) is highly informative in detection of pulmonary hypertension and right heart disorders in ASA patients. ECG is a screening method in diagnosis of pulmonary hypertension in ASA patients.

Adolescent↗
PubMed2004

[Vascular endothelial dysfunction in patients with chronic obstructive lung diseases].

At present data on endothelial dysfunction in chronic obstructive lung diseases (COLD) are lacking while in these diseases, favorable conditions are being established to develop endothelial dysfunction, namely: hypoxia, metabolic dysfunction of the lung endothelium, elevated levels of different biologically active substances, including cytokines, leukotrienes, etc. Sixty males with COLD, whose mean age was 51.16 +/- 1.13 years, were examined. A control group comprised 35 apparently healthy volunteers. Reactive hyperemia and nitroglycerin tests were performed to study endothelial function. The blood levels of desquamated endotheliocytes were determined by the method described by J. Hladovec (1978). According to the findings, the count of circulating endothelial cells was greater in patients with COLD than that in healthy individuals. In patients with severe COLD, the signs of endothelial lesion were most pronounced than in those with mild and moderate COLD. Patients with COLD showed a significantly lower level of current-dependent dilatation than did the controls. At the same time, patients with severe COLD exhibited a more marked decrease in endothelium-dependent dilatation than did those with mild and moderate COLD. Thus, patients with COLD have been found to have signs of endothelial lesion and impairments of the vasoregulatory activity of the vascular wall, which require further studies. These changes manifest themselves just in patients with mild and moderate COLD and they are most marked in patients with severe COLD.

Dilatation, Pathologic↗
PubMed2004

[Pulmonary hypertension right and left cardiac cavities in patients with systemic scleroderma].

Lung lesion is a most common organ changes in systemic scleroderma (SSD) detectable in approximately 70% of the patients at autopsy. Echocardiography is now one of the main non-invasive diagnostic methods for pulmonary hypertension (PH), in patients with scleroderma in particular. The study was undertaken to examine the incidence of PH and the specific features of its development in patients with SSD. Thirty-one patients with SSD (30 females and 1 males) treated at the rheumatological unit of the regional clinical hospital in 2000 to 2002 were examined. The patients' age ranged from 33 to 75 years (mean 47.7 +/- 1.7 years). Pulmonary systolic blood pressure (PSBP) (higher than 30 mm Hg) was recorded in 51.6% of the patients. Hypertrophy of the right ventricle (RV) (more than 0.5-cm increases in the thickness of its anterior wall) was found in 20 (64.5%) patients with SSD, 4 cases had hypertrophy of the RV anterior wall without resting elevated PSBP. More than 2.5-cm RV dilation was observed in 6 (19.4%) patients. This study has provided evidence for that echocardiography is of high informative value in detecting PH and right cardiac changes in patients with systemic scleroderma, which shows this technique to be a screening in these cases.

Adult↗
PubMed2004

[Pulmonary hypertension in patients with systemic scleroderma with CREST-syndrome and without it].

AIM: To study incidence rate and characteristics of pulmonary hypertension development in patients with systemic sclerosis (SS). MATERIAL AND METHODS: The study included 31 SS patients (30 females, 1 male, age 33-75 years, mean age 47.7 +/- 1.7 years). RESULTS: Pulmonary hypertension occurred more frequently in SS patients with CREST-syndrome than in SS patients free of this syndrome. SS patients with CREST-syndrome had also more severe ventricular hypertrophy than ventricular dilation. CONCLUSION: Echocardiography proved to be a highly informative method for detection of pulmonary hypertension in patients with SS. The necessity of hemodynamical study in SS patients is emphasized.

Adult↗
PubMed2004

[Pulmonary hypertension, involvement of the right and left cardiac parts in patients with ankylosing spondylarthritis].

The literature states that pulmonary hypertension (PH) may develop in ankylosing spondylarthritis (AS); however, there are virtually no evidence for its incidence and the specific features of lesions of the right and left cardiac portions. This study was undertaken to determine the incidence of PH and its specific features in patients with AS. Fifty-five patients with AS were examined. There were prevalent patients with predominantly spinal lesions (50.9%), moderate progression of the disease (61.8%), and Grade III sacroileitis (49.1%). PH was detected in 70.96% of the patients, hypertrophy of the right ventricle (RV) was observed in 47.3%, RV dilation was in 34.5%. There were increases in the end systolic size and volume of the left ventricle (LV) in patients with AS (p < 0.05 and p < 0.05, respectively), ventricular septal thickening (p < 0.05), and a tendency for the posterior LV wall to be thickened. LV diastolic dysfunction occurred in 25.9% of the patients with AS. The found changes were interrelated with the duration of disease, the involvement of the vertebral column, the thoracic part in particular. Thus, the high incidence of PH was ascertained in patients with AS. The study confirms that echocardiography is of high informative value in the detection of PH and right cardiac changes in patients with AS, which shows this method to be screening in identifying the above pathology.

Adolescent↗
PubMed2004

[Vasoregulating activity of the endothelium and pulmonary hypertension].

AIM: To examine vasoregulating endothelial activity in patients with bronchial asthma (BA) with pulmonary hypertension (PH) and free of PH. MATERIAL AND METHODS: A total of 62 BA patients aged between 19 and 52 entered the trial. They were divided into two groups: 44 with PH and 18 free of it. The control group consisted of 35 healthy subjects. Vasoregulating activity of the vascular wall was studied by tests with reactive hyperemia (endothelium-dependent dilation) and 0.05 mg nitroglycerin (endothelium-dependent dilation). RESULTS: It was found that BA patients with PH have a dilated brachial artery, abnormal endothelium-dependent vasodilation of the brachial artery. The artery is low sensitive to shift tension. These changes in functional activity of brachial artery endothelium in BA patients with PH are associated with impaired pulmonary hemodynamics, right ventricular diastolic function.

Adult↗
PubMed2003

[Steroidal vasculitis in patients with bronchial asthma: specific features of platelet function and antithrombogenic vascular activity].

Severe forms of bronchial asthma (BA) are encountered now more and more frequently. Therefore, number of patients treated by course steroids in BA exacerbation and patients on continuous basic therapy with systemic glucocorticosteroids(GCS) grows. Pathogenesis of steroid vasculitis (SV) is though to be related with GCS effect on the skin, hemostasis and directly on the vessels. We studied platelet function and antithrombogenic activity of vascular wall (AAVW) in patients with steroid-dependent BA (SDBA) in development of cutaneous hemorrhagic syndrome (CHS). We examined 30 patients with SDBA and cutaneous vasculitis and 19 SDBA patients free of this vasculitis. A control group consisted of 29 healthy volunteers. Assessment of ADP-induced platelet aggregation, AAVW demonstrates enhanced functional activity of platelets and definite impairment of antithrombogenic endothelial activity in patients with SDBA and CHS. We came to the conclusion that AAVW affection is involved in pathogenesis of SV in SDBA patients.

Adult↗
PubMed2003

[The study of circulating endothelial cells in patients with bronchial asthma].

To assess blood circulating endotheliocytes (CE) as a marker of endothelial dysfunction in patients with bronchial asthma (BA), 58 BA patients, aged 19-52, (mean age 37.7 +/- 1.8 years) were examined. The number of CE in the blood was measured by J. Hladovec method (1978). BA patients had a significantly elevated count of EC in active exacerbation and insignificantly elevated count in attenuating exacerbation compared to that of control healthy subjects. Thus, the severity of BA correlates with the severity of endothelial affection: patients with severe BA and with attenuating BA exacerbation had more CE than normal subjects while in moderate disease the CE levels in the patients and controls are comparable.

Adult↗