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Biomedical subjects

N A Kulikova

Publications and source records attributed to N A Kulikova.

At least 19 recordsLinked to original sources
PubMed1993

[Effect of prolonging the periods of endurance of mortal hypoxia during extracorporeal exposure to a magnetic field on the blood].

The influence of constant magnetic field to organism (through blood) during mortal hypoxia, combined with apnoea, was studied in 2 series of experiments in 38 dogs. It has been established that extracorporal influence of magnetic field to blood promotes 1.5 fold prolongation of animal's clinical death coming on the average after the cutting-off their breathing. Effect of prolongation of the mortal hypoxia sustaining periods was reached by complex influence of constant magnetic field (induction 0.1-0.5 TL) to circulated blood in extracorporal circuit with volume speed 20-25 ml/min/kg combined with short (2 min) inhalation of oxygen to lungs before apnoea.

Animals↗
PubMed1993

[Changes in the blood oxygen capacity under the action of a permanent magnetic field].

The level of oxygen the blood was tested in 2 series of experiment on 20 dogs where the of apneic hypoxia is used. In addition in stand investigations (35 cases) with donor blood the content of oxygen in the blood was checked during and after combined influence to the blood the constant magnetic field (CMF) and oxygen. Peculiarity of alterations of oxygen blood capacity on conditions of influence CMF was the fact, that in 3 min. after CMF action only comparatively little surplus rise the part of oxygen connected with haemoglobin was seen; meanwhile the oxygen tension increased more than 1.5 times. It is reasonable to consider that under the conditions of CMF influence very short, unstable and upper than calculative level of connection oxygen and haemoglobin took place and after stopping the influence of CMF this oxygen translocated to the instant (soluble) part. It stimulated the growth of oxygen tension in the blood and ensured required level of the total oxygen balance of the body during hypoxia.

Animals↗
PubMed1987

[Noradrenaline content of the brain of rats of various ages following adaptation to a new situation and to the development of a passive avoidance conditioned reflex].

Noradrenaline (NA) levels in cortico-striatal (including cerebral cortex, hippocamp, striatum) and hypothalamo-brainstem (including hypothalamus, thalamus, tectum + tegmentum) regions were determined by fluorometry in I- and 2-month-old male rats after 7-day adaptation to experimental conditions and passive avoidance learning by single electric foot shock. Neither the new environment nor a week's adaptation to it resulted in any significant alteration of NA content in both brain regions of 1- and 2-month-old rats. No considerable differences in NA levels were found in rats of both age groups with and without passive avoidance responses. But 24 hours after the exposure to foot shock NA basal levels markedly decreased in both brain regions of 1-month-old rats, while in 2-month-old ones NA basal levels markedly increased in hypothalamo-brainstem region.

Adaptation, Physiological↗
PubMed1984

[Function of the adrenal cortex during elaboration of the passive avoidance conditioned reflex in immature rats].

Plasma 11-hydroxycorticosteroid (11-OHCS) levels were measured in 30-day-old rats by fluorometry during passive avoidance (PA) learning by means of a single electric footshock. In contrast to the data obtained in adult animals, pre-exposure of young rats for 7 days to the experimental environment (over 3 min daily) resulted in elevation of the basal 11-OHCS levels and in the lack of distinct changes in the hormonal background after placing the young rats into a chamber. As in previous experiments on adult rats, one day after PA learning the 11-OHCS levels were significantly lower in young rats displaying PA than in the animals which did not exhibit PA behavior. Five days after PA training these differences in adrenocortical reactivity disappeared, as was the case in adult animals.

11-Hydroxycorticosteroids↗
PubMed1982

[Adrenal cortical function in elaborating a passive avoidance conditioned reflex in rats adapted to experimental conditions].

Fluorometry was used to determine the content of 11-hydroxycorticosteroids (11-HCS) in the blood plasma of 2-month-old male rats in the course of passive avoidance learning by means of single electrocutaneous irritation (ECI) of the limbs. Pre-exposure of the animals for 7 days to experimental environment (over 3 min daily) led to a distinct reduction of the basal content of 11-HCS which returned to the initial level after adaptation discontinuance. One day after ECI the content of 11-HCS in rats which learned passive avoidance, was appreciably lower as compared to that in the animals which failed to learn the behavioral task. Five days after ECI the differences in the content of the corticosteroids in the animals of the two groups were little pronounced. It appears that while using passive avoidance as a long-term memory model, account should be taken of both the behavioral and emotional responses.

11-Hydroxycorticosteroids↗
PubMed1976

[Adrenal cortical function in rats with traumatic shock following removal and deafferentation of the hypothalamus].

The 11-oxycorticosteroid (11-OCS) content was studied in the blood plasma of sham-operated rats, rats with intact, ablated and deafferentated medial-basal hypothalamus (MBH) in traumatic shock. There were no reliable differences in the 11-OCS basal level in various groups of rats. MBH ablation led to the reduction in the weight of adrenal and pituitary glands and MBH deafferentation -- to increase in the weight of the former. The 11-OCS level was reliably higher in traumatic shock of rats with complete MBH deafferentation than in sham-operated animals.

11-Hydroxycorticosteroids↗
PubMed1975

[The role of the adrenals in the development of hyperenzymemia in experimental multiple injuries].

The authors studied the activity of acid phosphatase (AP), lactic dehydrogenase (LDH), aspartic and alanine-aminotranspherases (AST and ALT) in the serum of rats with intact and removed adrenal glands after a severe multifocal trauma induced according to Noble-Collip (300 rpt of the drum with the rotation speed of 37 rpt/min). Adrenalectomy showed practically no influence on the dynamics of the LDH and AP activity. An increase in the activity of the AST and especially of the ALT in the serum of adrenalectomized rats after the trauma was considerably less than in the animals with the intact adrenal glands.

Acid Phosphatase↗
PubMedDate not supplied

[Ganglion block in cardiopulmonary bypass surgery].

Ganglion blockers increase the antinociceptive defense in anesthesiological support of cardiopulmonary bypass operations for mitral and aortic valve failure. Benzohexonium decreased total peripheral vascular resistance, increased cardiac and stroke indexes, and increased systolic potency of the heart. Ganglionar blocking was associated with an increase of systemic oxygen transport, arrhythmias developed rarely, blood concentrations of epinephrine, norepinephrine, ACTH, vasopressin, and leukinferon were lower.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Trichinelliasis in western Podolia].

Situation with trichinosis in the Ternopol Province (Ukraine) in the period from 1962 to 1987 was studied. Muscle samples taken from 6695 animals of 20 species were investigated by the compressor method and by the method of digestion in artificial gastric juice. Trichinosis was detected in wolves, foxes, martens, ferrets, domestic dogs, cats and gray rats. In 1954--1979 39 trichinosis cases were registered in humans with 4 lethal cases. Domestic pigs proved to be the source of invasion. Since 1980 up to the end of investigation trichinosis cases have not been registered in people or in domestic pigs. Trichinosis invasion of wild, domestic and synanthropic mammals has decreased. Large work is being carried out to realize antitrichinosis measures.

Age Factors↗